Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Christian Spenger"'
Autor:
Virginia Boccardi, Eric Westman, Luca Pelini, Olof Lindberg, J-Sebastian Muehlboeck, Andrew Simmons, Roberto Tarducci, Piero Floridi, Pietro Chiarini, Hilkka Soininen, Iwona Kloszewska, Magda Tsolaki, Bruno Vellas, Christian Spenger, Lars-Olof Wahlund, Simon Lovestone, Patrizia Mecocci
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2019)
Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddN
Externí odkaz:
https://doaj.org/article/58c76b47b14e47709bcd6c1dea3b5e69
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 221-228 (2007)
Megencephaly mice (BALB/cByJ-Kv1.1mceph/mceph) display excessive brain growth and seizures related to a mutation within the potassium channel gene Kv1.1 producing a malfunctioning protein. 1H Magnetic resonance spectroscopy (MRS) provides means to st
Externí odkaz:
https://doaj.org/article/4b8ae2d274c741dc8b0ed5a90810f45e
Autor:
Catharina Lavebratt, Alexandra Trifunovski, Ann-Sophie Persson, Fu-Hua Wang, Tomas Klason, Inger Öhman, Anna Josephsson, Lars Olson, Christian Spenger, Martin Schalling
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 374-383 (2006)
Carbamazepine (CBZ) is a commonly used antiepileptic drug known to block voltage-gated sodium channels. Infants exposed to CBZ in utero show reduced head circumference, for reasons unknown. We investigated CBZ's effect on neural growth in megencephal
Externí odkaz:
https://doaj.org/article/e88af1ebb0a44807abb8814b43bf0898
Autor:
Susanne Aileen Funke, Dirk Bartnik, Julian Marius Glück, Kasia Piorkowska, Katja Wiesehan, Urs Weber, Balazs Gulyas, Christer Halldin, Andrea Pfeifer, Christian Spenger, Andreas Muhs, Dieter Willbold
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41457 (2012)
Alzheimer's disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-β peptide (Aβ). While there has been some advancement
Externí odkaz:
https://doaj.org/article/ce9a1aae78d8452baa52b21d0c56408f
Autor:
Eric Westman, Lena Cavallin, J-Sebastian Muehlboeck, Yi Zhang, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kłoszewska, Hilkka Soininen, Christian Spenger, Simon Lovestone, Andrew Simmons, Lars-Olof Wahlund, AddNeuroMed consortium
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22506 (2011)
BackgroundVisual assessment rating scales for medial temporal lobe (MTL) atrophy have been used by neuroradiologists in clinical practice to aid the diagnosis of Alzheimer's disease (AD). Recently multivariate classification methods for magnetic reso
Externí odkaz:
https://doaj.org/article/3681448ab4164981b0ef2a06cae8d426
Autor:
Madhav Thambisetty, Andrew Simmons, Abdul Hye, James Campbell, Eric Westman, Yi Zhang, Lars-Olof Wahlund, Anna Kinsey, Mirsada Causevic, Richard Killick, Iwona Kloszewska, Patrizia Mecocci, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Christian Spenger, Simon Lovestone, AddNeuroMed Consortium
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28527 (2011)
Peripheral biomarkers of Alzheimer's disease (AD) reflecting early neuropathological change are critical to the development of treatments for this condition. The most widely used indicator of AD pathology in life at present is neuroimaging evidence o
Externí odkaz:
https://doaj.org/article/3154edc1e20d44daa20385f19cad5c52
Autor:
Luca Pelini, Lars-Olof Wahlund, Christian Spenger, Olof Lindberg, Eric Westman, Piero Floridi, Bruno Vellas, Roberto Tarducci, Virginia Boccardi, Magda Tsolaki, Simon Lovestone, Iwona Kłoszewska, Andrew Simmons, P. Chiarini, J-Sebastian Muehlboeck, Patrizia Mecocci, Hilkka Soininen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2019)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
Background/Aims: A bi-directional communication between the immune system and the central nervous system has been recently suggested. Among many cytokines, the role of IL-4 - with anti-inflammatory properties- in counteracting age-related inflammator
Autor:
Bruno Vellas, Herta Flor, Tomáš Paus, Herve Lemaitre, Gareth J. Barker, Lars Bäckman, Magda Tsolaki, Laura Fratiglioni, Michael N. Smolka, Wasim Khan, Hugh Garavan, Victor L. Villemagne, Iwona Kłoszewska, Christian Büchel, Frauke Nees, Bernd Ittermann, Grégoria Kalpouzos, Lars-Olof Wahlund, J-Sebastian Muehlboeck, Jeurgen Gallinat, Simon Lovestone, Patrizia Mecocci, Vincent Giampietro, Christian Spenger, Marcella Rietschel, Penny A. Gowland, Colin L. Masters, Steven Williams, Hilkka Soininen, G. Schumann, Zdenka Pausova, Andrew Simmons, Tobias Banaschewski, Patricia J. Conrod, A. Heinz, Vincent Frouin, Arun L.W. Bokde, Andreas Ströhle, Eric Westman
Publikováno v:
Journal of Alzheimer's Disease
Khan, W, Giampietro, V, Banaschewski, T, Barker, G J, Bokde, A L W, Büchel, C, Conrod, P, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lemaître, H, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Smolka, M N, Ströhle, A, Gallinat, J, Vellas, B, Soininen, H, Kloszewska, I, Tsolaki, M, Mecocci, P, Spenger, C, Villemagne, V L, Masters, C L, Muehlboeck, J S, Bäckman, L, Fratiglioni, L, Kalpouzos, G, Wahlund, L O, Schumann, G, Lovestone, S, Williams, S C R, Westman, E & Simmons, A 2017, ' A Multi-Cohort Study of ApoE ϵ 4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease ', JOURNAL OF ALZHEIMERS DISEASE, vol. 56, no. 3, pp. 1159-1174 . https://doi.org/10.3233/JAD-161097
Khan, W, Giampietro, V, Banaschewski, T, Barker, G J, Bokde, A L W, Büchel, C, Conrod, P, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lemaître, H, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Smolka, M N, Ströhle, A, Gallinat, J, Vellas, B, Soininen, H, Kloszewska, I, Tsolaki, M, Mecocci, P, Spenger, C, Villemagne, V L, Masters, C L, Muehlboeck, J S, Bäckman, L, Fratiglioni, L, Kalpouzos, G, Wahlund, L O, Schumann, G, Lovestone, S, Williams, S C R, Westman, E & Simmons, A 2017, ' A Multi-Cohort Study of ApoE ϵ 4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease ', JOURNAL OF ALZHEIMERS DISEASE, vol. 56, no. 3, pp. 1159-1174 . https://doi.org/10.3233/JAD-161097
The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer’s disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), we compared the effect of A
Autor:
Patrizia Mecocci, Joana B. Pereira, Eric Westman, Lars-Olof Wahlund, Bruno Vellas, Andrew Simmons, Carlos Aguilar, Iwona Kłoszewska, Gabriela Spulber, Simon Lovestone, H. Soininen, Dag Aarsland, Magda Tsolaki, Lena Cavallin, Christian Spenger
Publikováno v:
Journal of Internal Medicine. 275:317-330
Background Visual assessment of medial temporal lobe atrophy (MTA; range 0–4, from no atrophy to increasing atrophy of the choroid fissure, temporal horns and hippocampus) is a sensitive radiological marker of Alzheimer's disease (AD). One of the c
Autor:
Carlos Aguilar, J-Sebastian Muehlboeck, Patrizia Mecocci, Iwona Kłoszewska, Eric Westman, Lars-Olof Wahlund, Bruno Vellas, Magda Tsolaki, Simon Lovestone, Hilkka Soininen, Andrew Simmons, Christian Spenger
Publikováno v:
Psychiatry Research: Neuroimaging. 212:89-98
Automated structural magnetic resonance imaging (MRI) processing pipelines and different multivariate techniques are gaining popularity for Alzheimer's disease (AD) research. We used four supervised learning methods to classify AD patients and contro