Targeting neoantigens to APC-surface molecules improves the immunogenicity and anti-tumor efficacy of a DNA cancer vaccine

Autor: Marina Barrio-Calvo, Søren Vester Kofoed, Sofie Cens Holste, Anders Bundgård Sørensen, Nadia Viborg, Jens Vindahl Kringelum, Daniela Kleine-Kohlbrecher, Christian Skjødt Steenmans, Christian Bahne Thygesen, Birgitte Rønø, Stine Friis

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionTumor-specific mutations generate neoepitopes unique to the cancer that can be recognized by the immune system, making them appealing targets for therapeutic cancer vaccines. Since the vast majority of tumor mutations are patient-specific

Externí odkaz: https://doaj.org/article/9b0f27a2843c4416baaa84254e5596a1

ArrayPitope: Automated Analysis of Amino Acid Substitutions for Peptide Microarray-Based Antibody Epitope Mapping.

Autor: Christian Skjødt Hansen, Thomas Østerbye, Paolo Marcatili, Ole Lund, Søren Buus, Morten Nielsen

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0168453 (2017)

Identification of epitopes targeted by antibodies (B cell epitopes) is of critical importance for the development of many diagnostic and therapeutic tools. For clinical usage, such epitopes must be extensively characterized in order to validate speci

Externí odkaz: https://doaj.org/article/7da2fbada0ca40f7b63abcf36c023243

Defining lncRNAs Correlated with CHO Cell Growth and IgG Productivity by RNA-Seq

Autor: Søren Kofoed Rasmussen, Davide Vito, Jens Christian Eriksen, Dietmar Weilguny, C. Mark Smales, Christian Skjødt

Publikováno v: iScience
iScience, Vol 23, Iss 1, Pp-(2020)

Summary How the long non-coding RNA (lncRNA) genome in recombinant protein producing Chinese hamster ovary (CHO) cell lines relates to phenotype is not well described. We therefore defined the CHO cell lncRNA transcriptome from cells grown in control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cb2db8b391db39833188dde2b527d3

Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children

Autor: Regina Soldo, Zsolt Szépfalusi, Marta Ponce, Katrine Lindholm Bøgh, Christina Bannert, Andreas Weinhäusel, Stephen Kwok-Wing Tsui, Fabian Schroeder, Christian Skjødt Hansen, Thomas Eiwegger, Klara Schmidthaler

Publikováno v: Ponce, M, Schroeder, F, Bannert, C, Schmidthaler, K, Hansen, C S, Bøgh, K L, Soldo, R, Tsui, S K-W, Weinhäusel, A, Szépfalusi, Z & Eiwegger, T 2019, ' Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children ', Allergy, vol. 74, no. 4, pp. 780-787 . https://doi.org/10.1111/all.13658

Background The preventive effect of allergen immunotherapy (AIT) on allergy and asthma development is currently assessed using primary and secondary AIT approaches. Knowledge of the immunological effects of these interventions is limited and the impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f834511349c46617ac681dae05b359
https://orbit.dtu.dk/en/publications/fd0cad7e-e850-4591-9ff4-3a48890a8687

ArrayPitope: Automated Analysis of Amino Acid Substitutions for Peptide Microarray-Based Antibody Epitope Mapping

Autor: Ole Lund, Paolo Marcatili, Christian Skjødt Hansen, Morten Nielsen, Thomas Osterbye, Søren Buus

Publikováno v: Hansen, C S, Østerbye, T, Marcatili, P, Lund, O, Buus, S & Nielsen, M 2017, ' ArrayPitope: Automated Analysis of Amino Acid Substitutions for Peptide Microarray-Based Antibody Epitope Mapping ', P L o S One, vol. 12, no. 1, e0168453 . https://doi.org/10.1371/journal.pone.0168453
PLoS ONE
Hansen, C S, Østerbye, T, Marcatili, P, Lund, O, Buus, S & Nielsen, M 2017, ' ArrayPitope : Automated analysis of amino acid substitutions for peptide microarray-based antibody epitope mapping ', PLOS ONE, vol. 12, no. 1, e0168453 . https://doi.org/10.1371/journal.pone.0168453
PLoS ONE, Vol 12, Iss 1, p e0168453 (2017)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Identification of epitopes targeted by antibodies (B cell epitopes) is of critical importance for the development of many diagnostic and therapeutic tools. For clinical usage, such epitopes must be extensively characterized in order to validate speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b594ca500129eb0eed3f85f47799eae4
https://orbit.dtu.dk/en/publications/427ba532-eebb-470a-8aa8-7060137d95f2