Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Christian Siebold"'
Autor:
Tomas Malinauskas, Gareth Moore, Amalie F. Rudolf, Holly Eggington, Hayley L. Belnoue-Davis, Kamel El Omari, Samuel C. Griffiths, Rachel E. Woolley, Ramona Duman, Armin Wagner, Simon J. Leedham, Clair Baldock, Hilary L. Ashe, Christian Siebold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic develop
Externí odkaz:
https://doaj.org/article/ddfaa798787944ee8ae8169dabd72ec6
Autor:
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Publikováno v:
eLife, Vol 13 (2024)
The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and metastatic diseases. The domain(s) and mechanisms requ
Externí odkaz:
https://doaj.org/article/439dab7e296646b59ddc2e91b98ed24d
Autor:
T. Bertie Ansell, Wanling Song, Claire E. Coupland, Loic Carrique, Robin A. Corey, Anna L. Duncan, C. Keith Cassidy, Maxwell M. G. Geurts, Tim Rasmussen, Andrew B. Ward, Christian Siebold, Phillip J. Stansfeld, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution
Externí odkaz:
https://doaj.org/article/cf3afb5f6f044bce9bcb06b11105b64c
Autor:
Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights i
Externí odkaz:
https://doaj.org/article/420c08df587c4e738a4706dedda2d860
Autor:
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
Publikováno v:
eLife, Vol 10 (2021)
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et
Externí odkaz:
https://doaj.org/article/5a337fc10aa446e7ae5f2c2ad268a83d
Autor:
Daniel Rozbesky, Ross A. Robinson, Vitul Jain, Max Renner, Tomas Malinauskas, Karl Harlos, Christian Siebold, E. Yvonne Jones
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Semaphorin-plexin interactions regulate various developmental processes in Drosophila but the structural basis of these signaling events is unclear. Here, the authors present crystal structures of all Drosophila class 1 and 2 semaphorins, and elucida
Externí odkaz:
https://doaj.org/article/83d5a240211049d4bd6a9086ef4edd87
Autor:
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi
Publikováno v:
eLife, Vol 9 (2020)
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGR
Externí odkaz:
https://doaj.org/article/a16581bf514f46dfbee2a69f787da3db
Autor:
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
Publikováno v:
eLife, Vol 8 (2019)
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to
Externí odkaz:
https://doaj.org/article/5a2e3cba37c9448299797b131d5c2018
Autor:
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon FX Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
eLife, Vol 5 (2016)
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system i
Externí odkaz:
https://doaj.org/article/937ea17052e64dc28449bc38de2fd1a7
Autor:
Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
eLife, Vol 2 (2013)
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich do
Externí odkaz:
https://doaj.org/article/d808c19bbead4fb1b641ef3237212563