Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Christian Setz"'
Autor:
Christian Setz, Maximilian Große, Maria Fröba, Janina Auth, Pia Rauch, Alexandra Herrmann, Arne Cordsmeier, Armin Ensser, Michael Schindler, Martina Morokutti-Kurz, Philipp Graf, Benedikt Engel, Eva Prieschl-Grassauer, Andreas Grassauer, Ulrich Schubert
Publikováno v:
Nutraceuticals, Vol 3, Iss 3, Pp 315-328 (2023)
Even with its endemic transition, the COVID-19 pandemic remains a public health threat, particularly in the light of emerging variants of concern (VoCs) and the need for pandemic preparedness in the future. In November 2021, the SARS-CoV-2 VoC Omicro
Externí odkaz:
https://doaj.org/article/51e353443d9642e98d1a85c9d27ad327
Autor:
Christian Setz, Maria Fröba, Maximilian Große, Pia Rauch, Janina Auth, Alexander Steinkasserer, Stephan Plattner, Ulrich Schubert
Publikováno v:
Nutraceuticals, Vol 3, Iss 1, Pp 91-106 (2023)
Coronavirus disease-19 (COVID-19) is still affecting the lives of people round the globe and remains a major public health threat. The emergence of new variants more efficiently transmitted, more virulent and more capable of escaping naturally acquir
Externí odkaz:
https://doaj.org/article/daed3d04508846889bd1ffb5ee2b91f5
Publikováno v:
Viruses, Vol 15, Iss 4, p 1026 (2023)
Coronavirus disease-19 (COVID-19) is still affecting the lives of people around the globe and remains a major public health threat. Lipid levels in the host cells have been shown to promote SARS-CoV-2 replication, and since the start of COVID-19 pand
Externí odkaz:
https://doaj.org/article/661063ef8737428d861bf8a7087b7afc
Autor:
Maximilian Große, Christian Setz, Pia Rauch, Janina Auth, Martina Morokutti-Kurz, Vladimir Temchura, Ulrich Schubert
Publikováno v:
Viruses, Vol 14, Iss 7, p 1404 (2022)
The ubiquitin proteasome system (UPS), particularly its deubiquitinating enzymes (DUBs), play a key role in the replication cycle of coronaviruses. The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the rep
Externí odkaz:
https://doaj.org/article/7415be6efc4547eb99e082031f41ccbf
Autor:
Maximilian Große, Natalia Ruetalo, Mirjam Layer, Dan Hu, Ramona Businger, Sascha Rheber, Christian Setz, Pia Rauch, Janina Auth, Maria Fröba, Ekkehard Brysch, Michael Schindler, Ulrich Schubert
Publikováno v:
Viruses, Vol 13, Iss 4, p 647 (2021)
While vaccination campaigns are ongoing worldwide, there is still a tremendous medical need for efficient antivirals against SARS-CoV-2 infection. Among several drug candidates, chloroquine (CQN) and hydroxychloroquine (H-CQN) were tested intensively
Externí odkaz:
https://doaj.org/article/f2ec0f5c6e24485faa77c7db0364d4fd
Autor:
Friedrich Hahn, Adrian Schmalen, Christian Setz, Melanie Friedrich, Stefan Schlößer, Julia Kölle, Robert Spranger, Pia Rauch, Kirsten Fraedrich, Tatjana Reif, Julia Karius-Fischer, Ashok Balasubramanyam, Petra Henklein, Torgils Fossen, Ulrich Schubert
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174254 (2017)
There is a significantly higher risk for type II diabetes in HIV-1 carriers, albeit the molecular mechanism for this HIV-related pathology remains enigmatic. The 52 amino acid HIV-1 p6 Gag protein is synthesized as the C-terminal part of the Gag poly
Externí odkaz:
https://doaj.org/article/ff4f74b40c1748b0ba8e1d0e7fc126d2
Autor:
Friedrich Hahn, Christian Setz, Melanie Friedrich, Pia Rauch, Sara Marie Solbak, Nils Åge Frøystein, Petra Henklein, Jörg Votteler, Torgils Fossen, Ulrich Schubert
Publikováno v:
Viruses, Vol 6, Iss 10, Pp 3738-3765 (2014)
The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the cell membrane. It was recent
Externí odkaz:
https://doaj.org/article/f1abba788c204694adf1a465b5253234
Autor:
Adrian Schmalen, Julia Karius-Fischer, Pia Rauch, Christian Setz, Klaus Korn, Petra Henklein, Torgils Fossen, Ulrich Schubert
Publikováno v:
Viruses, Vol 10, Iss 12, p 710 (2018)
As part of the Pr55Gag polyprotein, p6 fulfills an essential role in the late steps of the replication cycle. However, almost nothing is known about the functions of the mature HIV-1 p6 protein. Recently, we showed that p6 is a bona fide substrate of
Externí odkaz:
https://doaj.org/article/e91b4b96925e4478a6f09e72f46365f7
Autor:
Christian Setz, Melanie Friedrich, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Maximilian Traxdorf, Ulrich Schubert
Publikováno v:
Viruses, Vol 9, Iss 8, p 222 (2017)
In recent years it has been well established that two major constituent parts of the ubiquitin proteasome system (UPS)—the proteasome holoenzymes and a number of ubiquitin ligases—play a crucial role, not only in virus replication but also in the
Externí odkaz:
https://doaj.org/article/70df03217bc849728e8caf64404a3fa6
Autor:
Christian Setz, Melanie Friedrich, Sabine Hahn, Jan Dörrie, Niels Schaft, Gerold Schuler, Ulrich Schubert
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55567 (2013)
N-terminal stable in frame fusion of ubiquitin (Ub) has been shown to target the fusion protein for proteasomal degradation. This pathway, called the Ub fusion degradation (UFD), might also elevate MHC class I (MHC-I) antigen presentation of specific
Externí odkaz:
https://doaj.org/article/75d81244feae4c04be1d25e5be5ec0f7