Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Christian Seiser"'
Autor:
Lena Hess, Verena Moos, Arnel A Lauber, Wolfgang Reiter, Michael Schuster, Natascha Hartl, Daniel Lackner, Thorina Boenke, Anna Koren, Paloma M Guzzardo, Brigitte Gundacker, Anna Riegler, Petra Vician, Claudia Miccolo, Susanna Leiter, Mahesh B Chandrasekharan, Terezia Vcelkova, Andrea Tanzer, Jun Qi Jun, James Bradner, Gerald Brosch, Markus Hartl, Christoph Bock, Tilmann Bürckstümmer, Stefan Kubicek, Susanna Chiocca, Srividya Bhaskara, Christian Seiser
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010376 (2022)
The class I histone deacetylases are essential regulators of cell fate decisions in health and disease. While pan- and class-specific HDAC inhibitors are available, these drugs do not allow a comprehensive understanding of individual HDAC function, o
Externí odkaz:
https://doaj.org/article/c86be04b9ac647019e3b6f55aae8c7bf
Autor:
Bettina Zierfuss, Isabelle Weinhofer, Agnieszka Buda, Niko Popitsch, Lena Hess, Verena Moos, Simon Hametner, Stephan Kemp, Wolfgang Köhler, Sonja Forss‐Petter, Christian Seiser, Johannes Berger
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2161-2177 (2020)
Abstract Objective To assess class I‐histone deacetylase (HDAC) inhibition on formation of lipid‐accumulating, disease‐promoting phagocytes upon myelin load in vitro, relevant for neuroinflammatory disorders like multiple sclerosis (MS) and cer
Externí odkaz:
https://doaj.org/article/40f371d81c5841558e4739b6c421dc16
Autor:
Bettina Zierfuss, Isabelle Weinhofer, Jörn‐Sven Kühl, Wolfgang Köhler, Annette Bley, Katharina Zauner, Johannes Binder, Ksenija Martinović, Christian Seiser, Christoph Hertzberg, Stephan Kemp, Gerda Egger, Gerda Leitner, Jan Bauer, Christoph Wiesinger, Markus Kunze, Sonja Forss‐Petter, Johannes Berger
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 639-652 (2020)
Abstract Objective To identify a pharmacological compound targeting macrophages, the most affected immune cells in inflammatory X‐linked adrenoleukodystrophy (cerebral X‐ALD) caused by ABCD1 mutations and involved in the success of hematopoietic
Externí odkaz:
https://doaj.org/article/25a19368269e4040bd9f1f687a1e1952
Autor:
Roland Tschismarov, Sonja Firner, Cristina Gil-Cruz, Lisa Göschl, Nicole Boucheron, Günter Steiner, Patrick Matthias, Christian Seiser, Burkhard Ludewig, Wilfried Ellmeier
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110576 (2014)
Reversible lysine acetylation plays an important role in the regulation of T cell responses. HDAC1 has been shown to control peripheral T helper cells, however the role of HDAC1 in CD8+ T cell function remains elusive. By using conditional gene targe
Externí odkaz:
https://doaj.org/article/84efecc701714eb29d8a7da10a49b529
Autor:
Martha V Koerner, Florian M Pauler, Quanah J Hudson, Federica Santoro, Anna Sawicka, Philipp M Guenzl, Stefan H Stricker, Yvonne M Schichl, Paulina A Latos, Ruth M Klement, Katarzyna E Warczok, Jacek Wojciechowski, Christian Seiser, Robert Kralovics, Denise P Barlow
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002540 (2012)
A CpG island (CGI) lies at the 5' end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited chromosomes. In addition to being modified on maternally inherited chromosomes by a DNA meth
Externí odkaz:
https://doaj.org/article/101388fd6d6d45abbce01052c01e8d80
Autor:
Reinhard Brunmeir, Sabine Lagger, Elisabeth Simboeck, Anna Sawicka, Gerda Egger, Astrid Hagelkruys, Yu Zhang, Patrick Matthias, Wolfgang J. Miller, Christian Seiser
Publikováno v:
PLoS Genetics, Vol 7, Iss 1 (2011)
Externí odkaz:
https://doaj.org/article/9bd3aa793f7a450a930a335884a95c4b
Autor:
Reinhard Brunmeir, Sabine Lagger, Elisabeth Simboeck, Anna Sawicka, Gerda Egger, Astrid Hagelkruys, Yu Zhang, Patrick Matthias, Wolfgang J Miller, Christian Seiser
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000927 (2010)
Large fractions of eukaryotic genomes contain repetitive sequences of which the vast majority is derived from transposable elements (TEs). In order to inactivate those potentially harmful elements, host organisms silence TEs via methylation of transp
Externí odkaz:
https://doaj.org/article/d991c3c57bb54eab9f621b827ac309cd
Autor:
Ci Zhu, Valentina Stolz, Natalija Simonovic, Osamah Al-Rubaye, Terezia Vcelkova, Verena Moos, Lena Hess, Astrid Hagelkruys, Moritz Madern, Wolfgang Reiter, Arabella Meixner, Christoph Bock, Markus Hartl, Ellmeier Ellmeier, Christian Seiser
Histone deacetylases are key epigenetic regulators that control T cell-mediated immunity. A T cell-specific deletion ofHdac1(HDAC1cKO) protects mice against experimental autoimmune encephalomyelitis (EAE). However, it remains elusive whether inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f63335e54e471d2d36262cf434fd60
https://doi.org/10.1101/2023.04.14.536700
https://doi.org/10.1101/2023.04.14.536700
Autor:
Terezia Vcelkova, Wolfgang Reiter, Martha Zylka, David M. Hollenstein, Stefan Schuckert, Markus Hartl, Christian Seiser
Post-translational modifications of histones are important regulators of the DNA damage response (DDR). By using affinity purification mass spectrometry (AP-MS) we discovered that genetic suppressor element 1 (GSE1) forms a complex with the HDAC1/CoR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2a5b7eab29c842d59389b5acc2e0a9
https://doi.org/10.1101/2023.03.13.532402
https://doi.org/10.1101/2023.03.13.532402
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8aa2d67c1dbdba85d5c55b511486071
https://doi.org/10.1007/978-1-0716-2788-4_4
https://doi.org/10.1007/978-1-0716-2788-4_4