Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christian Schleberger"'
Autor:
Ulrich Hommel, Konstanze Hurth, Jean-Michel Rondeau, Anna Vulpetti, Daniela Ostermeier, Andreas Boettcher, Jacob Peter Brady, Michael Hediger, Sylvie Lehmann, Elke Koch, Anke Blechschmidt, Rina Yamamoto, Valentina Tundo Dottorello, Sandra Haenni-Holzinger, Christian Kaiser, Philipp Lehr, Andreas Lingel, Luca Mureddu, Christian Schleberger, Jutta Blank, Paul Ramage, Felix Freuler, Joerg Eder, Frédéric Bornancin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Human interleukin-1β (hIL-1β) is a pro-inflammatory cytokine involved in many diseases. While hIL-1β directed antibodies have shown clinical benefit, an orally available low-molecular weight antagonist is still elusive, limiting the appli
Externí odkaz:
https://doaj.org/article/045a20bdd9464a2d8a11a51d75b0961e
Identifying peptides associated with the major histocompability complex class II (MHCII) is a central task in the evaluation of the immunoregulatory function of therapeutics and drug prototypes. MHCII-peptide presentation prediction has multiple biop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f4e950010a230cbffa9d57b95234207
https://doi.org/10.1101/2022.08.19.504560
https://doi.org/10.1101/2022.08.19.504560
Autor:
Wolfgang Jahnke, José A. Márquez, Andreas Marzinzik, Irina Cornaciu, Christian Schleberger, Lena Münzker, Joy Kristin Petrick, Gerhard Klebe, Rainer Wilcken, Damien Clavel
Publikováno v:
ChemBioChem. 21:3096-3111
Trypanosoma brucei is the causative agent of human African trypanosomiasis (HAT). Nitrogen-containing bisphosphonates, a current treatment for bone diseases, have been shown to block the growth of the T. brucei parasites by inhibiting farnesyl pyroph
Autor:
Christian Schleberger, Joseph Fanous, Sandra Söderholm, Adrian Egli, Johanna Ude, Olivier Cunrath, Dirk Bumann, Beatrice Claudi, Vishwachi Tripathi, Julien M. Buyck, Sebastian Hiller
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (31), ⟨10.1073/pnas.2107644118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (31), ⟨10.1073/pnas.2107644118⟩
International audience; Gram-negative bacterial pathogens have an outer membrane that restricts entry of molecules into the cell. Water-filled protein channels in the outer membrane, so-called porins, facilitate nutrient uptake and are thought to ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba07578fd84ed4fa37078e29766610
Autor:
Alexander Schmidt, Gaëtan L. A. Mislin, Etienne Baco, Christian Schleberger, Aurélie Paulen, Quentin Perraud, Véronique Gasser, Pamela Saint August, Nicolas Zill, Isabelle J. Schalk, Olivier Cunrath, Dirk Bumann
Publikováno v:
Environmental Microbiology. 18:819-832
Previous studies have suggested that antibiotic vectorization by siderophores (iron chelators produced by bacteria) considerably increases the efficacy of such drugs. The siderophore serves as a vector: when the pathogen tries to take up iron via the
Autor:
Bert van den Berg, Matteo Ceccarelli, Richard Wagner, Christian Schleberger, M. Pathania, Tommaso D'Agostino, Igor Bodrenko, Dirk Bumann, Mathias Winterhalter, Silvia Acosta-Gutierrez, Susruta Samanta, Ishan Ghai
Publikováno v:
ACS infectious diseases. 4(10)
Understanding molecular properties of outer membrane channels of Gram-negative bacteria is of fundamental significance as they are the entry point of polar antibiotics into bacteria. Outer membrane proteomics revealed OccK8 (OprE) to be among the fiv
Autor:
Dirk Bumann, Mathias Winterhalter, Ulrich Kleinekathöfer, Satya Prathyusha Bhamidimarri, Jigneshkumar Dahyabhai Prajapati, Christian Schleberger, Jennifer Hoover, Sandra Söderholm, Michael Zahn, Josh West, Bert van den Berg
Research efforts to discover potential new antibiotics for Gram-negative bacteria suffer from high attrition rates due to the synergistic action of efflux systems and the limited permeability of the outer membrane (OM). One potential strategy to over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931296d80eccb1200ebeaa28fb9feef3
https://doi.org/10.1101/306035
https://doi.org/10.1101/306035
Autor:
Bert van den Berg, Jigneshkumar Dahyabhai Prajapati, Ulrich Kleinekathöfer, Sandra Söderholm, Satya Prathyusha Bhamidimarri, Jennifer Hoover, Christian Schleberger, Dirk Bumann, Mathias Winterhalter, Josh West, Michael Zahn
Publikováno v:
Structure. 27:268-280.e6
Research efforts to discover potential new antibiotics for Gram-negative bacteria suffer from high attrition rates due to the synergistic action of efflux systems and the limited permeability of the outer membrane (OM). One strategy to overcome the O
Autor:
Véronique, Gasser, Etienne, Baco, Olivier, Cunrath, Pamela Saint, August, Quentin, Perraud, Nicolas, Zill, Christian, Schleberger, Alexander, Schmidt, Aurélie, Paulen, Dirk, Bumann, Gaëtan L A, Mislin, Isabelle J, Schalk
Publikováno v:
Environmental microbiology. 18(3)
Previous studies have suggested that antibiotic vectorization by siderophores (iron chelators produced by bacteria) considerably increases the efficacy of such drugs. The siderophore serves as a vector: when the pathogen tries to take up iron via the
Publikováno v:
Bioinformatics
Motivation: Prochlorococcus possesses the smallest genome of all sequenced photoautotrophs. Although the number of regulatory proteins in the genome is very small, the relative number of small regulatory RNAs is comparable with that of other bacteria