Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Christian Schönbeck"'
Publikováno v:
Samuelsen, L, Larsen, D, Schönbeck, C & Beeren, S R 2022, ' pH-Responsive templates modulate the dynamic enzymatic synthesis of cyclodextrins ', Chemical Communications, vol. 58, pp. 5152-5155 . https://doi.org/10.1039/d1cc06554h
Product selection in the dynamic enzymatic synthesis of cyclodextrins can be controlled by changing the pH. Using cyclodextrin glucanotransferase to make labile the glycosidic linkages in cyclodextrins (CDs), we generate a dynamic combinatorial libra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffeb5ed6d2c682d5288632fd72cd2c4
https://doi.org/10.1039/d1cc06554h
https://doi.org/10.1039/d1cc06554h
Publikováno v:
Samuelsen, L, Holm, R & Schönbeck, C 2022, ' Exploring the interactions between buffers and cyclodextrin complexes—formation of regular inclusion or atypical non-inclusion complexes ', Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 102, pp. 151-158 . https://doi.org/10.1007/s10847-021-01111-4
The aim of this study was for the first time to determine the effect of 11 buffers on a γ-cyclodextrin complex, and use these and previous reported data to systematically explore the effect of buffers on different cyclodextrin complexes, considering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3773c93359e645867e9b4cd9f492277
https://doi.org/10.1007/s10847-021-01111-4
https://doi.org/10.1007/s10847-021-01111-4
Publikováno v:
Samuelsen, L, Holm, R & Schönbeck, C 2021, ' Simultaneous determination of cyclodextrin stability constants as a function of pH and temperature – A tool for drug formulation and process design ', Journal of Drug Delivery Science and Technology, vol. 65, 102675 . https://doi.org/10.1016/j.jddst.2021.102675
The stability constant for complex formation is an important physicochemical property used to guide drug formulation development with cyclodextrins. Complex formation depends on both pH and temperature, factors often altered during pharmaceutical pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e469d05e6ebb1799cfac0f8ebaadb9
https://findresearcher.sdu.dk:8443/ws/files/184504482/1_s2.0_S1773224721003555_main.pdf
https://findresearcher.sdu.dk:8443/ws/files/184504482/1_s2.0_S1773224721003555_main.pdf
Publikováno v:
International Journal of Pharmaceutics. 560:357-364
Solution pH is an important factor during drug formulation and processing. Changes in pH present challenges. Regulation of pH is typically managed by using a buffer system, which must have a suitable pKa. The pKa of buffers depends on temperature, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38074bd2b743351f0cf1194414018fe6
https://doi.org/10.1016/j.ijpharm.2019.02.019
https://doi.org/10.1016/j.ijpharm.2019.02.019
Publikováno v:
Journal of pharmaceutical sciences. 110(7)
The effect of 11 buffers as well as the effect of ionic strength were investigated on the binding between the bile salt taurochenodeoxycholate and the ionic sulfobutylether-β-cyclodextrin. The investigations showed that both ionic strength and compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9b300c816dbd4a4094f1c5ada254ab
https://pubmed.ncbi.nlm.nih.gov/33607189
https://pubmed.ncbi.nlm.nih.gov/33607189
Publikováno v:
International journal of pharmaceutics. 589
Thirteen buffers were investigated for their effect on the binding of adamantanol to β-cyclodextrin and hydroxypropyl-β-cyclodextrin. Stability constants for the β-cyclodextrin complex ranged from 14,800 to 46,000 M−1, and the binding enthalpies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7472a0a108836e1e7eb9d4dbed7bb243
https://pubmed.ncbi.nlm.nih.gov/32916213
https://pubmed.ncbi.nlm.nih.gov/32916213
Publikováno v:
International journal of pharmaceutics. 585
Complex formation between cyclodextrins and ionizable guest molecules depends on pH. In general, the neutral species of an ionizable guest molecule has the highest affinity for the cyclodextrin cavity, but ionized species will also be able to form co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c56d039d352384dd35c7d5b79d8dd6
https://pubmed.ncbi.nlm.nih.gov/32502687
https://pubmed.ncbi.nlm.nih.gov/32502687
Autor:
René Holm, Tobias Løvgren Madsen, Günther H.J. Peters, Thorsteinn Loftsson, Christian Schönbeck
Publikováno v:
Schönbeck, C, Madsen, T L, Peters, G H, Holm, R & Loftsson, T 2017, ' Soluble 1:1 complexes and insoluble 3:2 complexes-Understanding the phase-solubility diagram of hydrocortisone and γ-cyclodextrin ', International Journal of Pharmaceutics, vol. 531, no. 2, 504-511 . https://doi.org/10.1016/j.ijpharm.2017.05.024
The molecular mechanisms underlying the drug-solubilizing properties of γ-cyclodextrin were explored using hydrocortisone as a model drug. The BS-type phase-solubility diagram of hydrocortisone with Υ-cyclodextrin was thoroughly characterized by me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e8abf9ba4bb6d52817f1ecb47335c1
https://doi.org/10.1016/j.ijpharm.2017.05.024
https://doi.org/10.1016/j.ijpharm.2017.05.024
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 184
The advantage of isothermal titration calorimetry (ITC) to determine the acid dissociation constant (pKa value) is the simultaneous determination of the binding constant and binding enthalpy, as well as being precise and easy to use. The pKa can be c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc73ebd17b3e18ef4fc4021c1cfd781f
https://pubmed.ncbi.nlm.nih.gov/32126458
https://pubmed.ncbi.nlm.nih.gov/32126458
Autor:
Christian Schönbeck
Publikováno v:
The journal of physical chemistry. B. 123(46)
Binding constants for thousands of cyclodextrin complexes have been reported in the literature, but much less is known about the kinetics of these host-guest complexes. In the present study, inclusion complexes of bile salts with β-cyclodextrin, γ-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a8c77347330481517999e468a3f5bf
https://pubmed.ncbi.nlm.nih.gov/31664833
https://pubmed.ncbi.nlm.nih.gov/31664833