Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Christian S. Lentz"'
Autor:
Jonathan Hira, Bhupender Singh, Tirthankar Halder, Anel Mahmutovic, Clement Ajayi, Arif Ahmed Sekh, Kristin Hegstad, Mona Johannessen, Christian S. Lentz
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Isogenic bacterial cell populations are phenotypically heterogenous and may include subpopulations of antibiotic tolerant or heteroresistant cells. The reversibility of these phenotypes and lack of biomarkers to differentiate functionally di
Externí odkaz:
https://doaj.org/article/9d5a74d86c664f9bb3e433fe6344da1e
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT The dCas9-based Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) interference (CRISPRi) gene regulation technique requires two components: a catalytically inactive Cas9 protein (dCas9) and a single-guide RNA that targets th
Externí odkaz:
https://doaj.org/article/79c63e1951bd4912b43c3f8b5913f8a5
Publikováno v:
mSystems, Vol 9, Iss 4 (2024)
ABSTRACTIn the Staphylococcus aureus genome, a set of highly conserved two-component systems (TCSs) composed of histidine kinases (HKs) and their cognate response regulators (RRs) sense and respond to environmental stimuli, which drive the adaptation
Externí odkaz:
https://doaj.org/article/ce96cfe8093e4896bc1574574d6f7cbf
Autor:
Frederick M. Tomlin, Ulla I. M. Gerling-Driessen, Yi-Chang Liu, Ryan A. Flynn, Janakiram R. Vangala, Christian S. Lentz, Sandra Clauder-Muenster, Petra Jakob, William F. Mueller, Diana Ordoñez-Rueda, Malte Paulsen, Naoko Matsui, Deirdre Foley, Agnes Rafalko, Tadashi Suzuki, Matthew Bogyo, Lars M. Steinmetz, Senthil K. Radhakrishnan, Carolyn R. Bertozzi
Publikováno v:
ACS Central Science, Vol 3, Iss 11, Pp 1143-1155 (2017)
Externí odkaz:
https://doaj.org/article/deaad0a3f1e64ba9ac1a503375d3faa2
Publikováno v:
Molecules, Vol 25, Iss 21, p 4949 (2020)
Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural features of bacterial cells for the first time. In this review article we will illustrate
Externí odkaz:
https://doaj.org/article/6045b29d45c143bca9a84071a1f96c7a
Autor:
Chen Linhai, Christian S. Lentz, Matthew Bogyo, Jodi L. Brewster, Peter D. Mace, Matthias Fellner, Sam A. Jamieson
Publikováno v:
ACS Infectious Diseases. 6:2771-2782
Staphylococcus aureus is a prevalent bacterial pathogen in both community and hospital settings, and its treatment is made particularly difficult by resilience within biofilms. Within this niche, serine hydrolase enzymes play a key role in generating
Autor:
Eranthie Weerapana, Y. Erin Chen, Laura J. Keller, Matthew Bogyo, Rebecca J. Metivier, Michael A. Fischbach, Christian S. Lentz
Publikováno v:
ACS Infectious Diseases. 6:930-938
The bacterial genus Staphylococcus comprises diverse species that colonize the skin as commensals but can also cause infection. Previous work identified a family of serine hydrolases termed fluorop...
Publikováno v:
Angewandte Chemie. 131:5699-5703
Publikováno v:
Angewandte Chemie International Edition. 58:5643-5647
Phenotypically distinct cellular (sub)populations are clinically relevant for the virulence and antibiotic resistance of a bacterial pathogen, but functionally different cells are usually indistinguishable from each other. Herein, we introduce fluore
Autor:
Matthias, Fellner, Christian S, Lentz, Sam A, Jamieson, Jodi L, Brewster, Linhai, Chen, Matthew, Bogyo, Peter D, Mace
Publikováno v:
ACS infectious diseases. 6(10)