Community guidelines for GPCR ligand bias: IUPHAR review 32

Autor: Peter Kolb, Terry Kenakin, Stephen P. H. Alexander, Marcel Bermudez, Laura M. Bohn, Christian S. Breinholt, Michel Bouvier, Stephen J. Hill, Evi Kostenis, Kirill A. Martemyanov, Rick R. Neubig, H. Ongun Onaran, Sudarshan Rajagopal, Bryan L. Roth, Jana Selent, Arun K. Shukla, Martha E. Sommer, David E. Gloriam

Publikováno v: Kolb, P, Kenakin, T, Alexander, S P H, Bermudez, M, Bohn, L M, Breinholt, C S, Bouvier, M, Hill, S J, Kostenis, E, Martemyanov, K A, Neubig, R R, Onaran, H O, Rajagopal, S, Roth, B L, Selent, J, Shukla, A K, Sommer, M E & Gloriam, D E 2022, ' Community guidelines for GPCR ligand bias : IUPHAR review 32 ', British Journal of Pharmacology, vol. 179, no. 14, pp. 3651-3674 . https://doi.org/10.1111/bph.15811

GPCRs modulate a plethora of physiological processes and mediate the effects of one-third of FDA-approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm

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http://hdl.handle.net/10230/53439