Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Christian S Thudium"'
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 4, Pp 100527- (2024)
Objective: The development of disease-modifying drugs is limited by OA's heterogeneity and the challenge of defining clinical endpoints. Serological biomarkers are considered potential surrogate endpoints, but their contribution from single joints to
Externí odkaz:
https://doaj.org/article/ea2442c807d1402bb80cfccc878e23d5
Autor:
Sofie Falkenløve Madsen, Sarah Spliid Madsen, Alexander Scheller Madrid, Mikkel Rathsach Andersen, Anne-Christine Bay-Jensen, Christian S. Thudium
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Background We aimed to investigate the development of synovial fibrosis in vitro and how the fibrosis can be halted. Synovial fibrosis causes joint stiffness in arthritic diseases. The pathway of the fibrotic growth factor, transforming grow
Externí odkaz:
https://doaj.org/article/5891c057397349e08699b0e2b5ee9800
Autor:
Sofie Falkenløve Madsen, Dovile Sinkeviciute, Christian S. Thudium, Morten A. Karsdal, Anne-Christine Bay-Jensen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Type III collagen gene expression is upregulated in the synovium of patients with rheumatoid arthritis (RA) presenting the fibroid phenotype. The soluble type III collagen formation biomarker, PRO-C3, is known to measure fibrogenesis in fibr
Externí odkaz:
https://doaj.org/article/9dfeba6e89044064af703a8e285e3add
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Objectives Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation in multiple articular joints, causing pain, joint damage, and loss of joint function. Despite the successful development of disease-modifying
Externí odkaz:
https://doaj.org/article/d632f2e3b3814913af442492e9664f63
Autor:
Kim Henriksen, Carmen Flores, Jesper S Thomsen, Anne-Marie Brüel, Christian S Thudium, Anita V Neutzsky-Wulff, Geerling E J Langenbach, Natalie Sims, Maria Askmyr, Thomas J Martin, Vincent Everts, Morten A Karsdal, Johan Richter
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27482 (2011)
Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone formation is normal or increased. In contrast the bones are of poor quality, despite this unco
Externí odkaz:
https://doaj.org/article/bef47f5349184095b0d171e838af7d8b
Autor:
Solveig Skovlund Groen, Anne-Christine Bay-Jensen, Christian S. Thudium, Morten H. Dziegiel, Marie Skougaard, Simon Francis Thomsen, Signe Holm Nielsen
Publikováno v:
Journal of Translational Autoimmunity, Vol 8, Iss , Pp 100231- (2024)
Introduction: T-helper 17 (Th17) cells produce IL-17A playing a critical role in activating the pathogenic chain leading to joint tissue inflammation and destruction. Elevated levels of Th17 cells and IL-17A have been detected in skin lesions, blood,
Externí odkaz:
https://doaj.org/article/40f6e7b313804048a32321f03f010197
Autor:
Sofie Falkenløve Madsen, Jannie Marie Bülow Sand, Pernille Juhl, Morten Karsdal, Christian S. Thudium, Anne Sofie Siebuhr, Anne-Christine Bay-Jensen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Systemic Sclerosis (SSc) hallmark is skin fibrosis, but up to 80% of the patients have fibrotic involvement in the pulmonary system. Antifibrotic drugs which have failed in a general SSc population have now been approved in patients with SSc
Externí odkaz:
https://doaj.org/article/a9d9e7074d394238a6c98a198ecf3cbc
Autor:
Jonathan J. Bjerre-Bastos, Nizar Hamrouni, Yves Henrotin, Christian S. Thudium, Asger R. Bihlet
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 4, Pp 100390- (2023)
Objective: Arthritic cartilage is primed for mechanical damage. Joint biochemical markers (JBM) could provide insight into the impact of mechanical stimulation on joint tissue turnover in osteoarthritis (OA) of potential use in clinical OA research a
Externí odkaz:
https://doaj.org/article/70e4c87ad7d34718a86a8f1155cf9265
Autor:
Christian S. Thudium, Amalie Engstrøm, Anne-Christine Bay-Jensen, Peder Frederiksen, Nuria Jansen, Arjan De Zwart, Marike van der Leeden, Joost Dekker, Willem Lems, Leo Roorda, Willem Evert van Spil, Martin Van der Esch
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-8 (2023)
Abstract Objectives To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoarthritis (OA). To study
Externí odkaz:
https://doaj.org/article/b3db53bd49464766b5917216a4b81595
Autor:
Anne C. Bay-Jensen, Mukundan Attur, Jonathan Samuels, Christian S. Thudium, Steven B. Abramson, Morten A. Karsdal
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 3, Pp 100379- (2023)
Background: The lack of disease modifying drugs in Osteoarthritis (OA) may be attributed to the difficulty in robust response based on patient-reported outcomes (PROs) linked to drug mechanism of action. Joint tissue turnover biomarkers are associate
Externí odkaz:
https://doaj.org/article/2f013bd017994433b08da053806363eb