Abolishing Myofibroblast Arrhythmogeneicity by Pharmacological Ablation of α-Smooth Muscle Actin Containing Stress Fibers

Autor: Teddy Grand, Stephan Schmutz, Stephan Rohr, Nicolò Salvarani, Christian Rosker

Publikováno v: Rosker, Christian; Salvarani, Nicolò; Schmutz, Stephan; Grand, Teddy; Rohr, Stephan (2011). Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of α-smooth muscle actin containing stress fibers. Circulation research, 109(10), pp. 1120-1131. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.111.244798
CIRCULATION RESEARCH

Rationale: Myofibroblasts typically appear in the myocardium after insults to the heart like mechanical overload and infarction. Apart from contributing to fibrotic remodeling, myofibroblasts induce arrhythmogenic slow conduction and ectopic activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c14076b5e0c121272730ae480105313
https://doi.org/10.1161/circresaha.111.244798

The GIRK1 Brain Variant GIRK1d and Its Functional Impact on Heteromultimeric GIRK Channels

Autor: Wolfgang Schreibmayer, Bibiane Steinecker, Christian Rosker

Publikováno v: Journal of Receptors and Signal Transduction. 27:369-382

Four isoforms of GIRK channels (GIRK1-4) have been described in humans. In addition, several splice variants of more or less unknown function have been identified from several tissues and species. In our study, we investigated the structure and funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1b077aff002ae09af360d2bc23d140
https://doi.org/10.1080/10799890701713073

TRPC3 and TRPC4 Associate to Form a Redox-sensitive Cation Channel

Autor: Michael Poteser, Petra Eder, Heike Kahr, Christian Rosker, Annarita Graziani, Isabella Derler, Klaus Groschner, Christoph Romanin, Michael X. Zhu

Publikováno v: Journal of Biological Chemistry. 281:13588-13595

Canonical transient receptor potential proteins (TRPC) have been proposed to form homo- or heteromeric cation channels in a variety of tissues, including the vascular endothelium. Assembly of TRPC multimers is incompletely understood. In particular,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad9e9f8b17ec51d2e67cf0c8ad590616
https://doi.org/10.1074/jbc.m512205200

TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals

Autor: Klaus Groschner, Christian Rosker

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 371:251-256

Transient receptor potential (TRP) proteins have been recognized as sensors for a wide variety of external and internal signals involved in maintenance of cellular homeostasis and control of physiological functions. Evidence of a striking versatility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc12d497bd8d93f032fe3585761f4ce
https://doi.org/10.1007/s00210-005-1054-6

Crosstalk Between Voltage-Independent Ca 2+ Channels and L-Type Ca 2+ Channels in A7r5 Vascular Smooth Muscle Cells at Elevated Intracellular pH

Autor: Rainer Schindl, Margot Teubl, Christoph Romanin, Christian Rosker, Klaus Groschner, Ichiro Wakabayashi, Michael Poteser, Nikolai M. Soldatov

Publikováno v: Circulation Research. 92:888-896

This study was designed to investigate the role of voltage-independent and voltage-dependent Ca 2+ channels in the Ca 2+ signaling associated with intracellular alkalinization in A7r5 vascular smooth muscle cells. Extracellular administration of ammo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::367a4830478393aa3aa402c5b1547d73
https://doi.org/10.1161/01.res.0000069216.80612.66