Differential recognition of influenza A virus H1N1 neuraminidase by DNA vaccine-induced antibodies in pigs and ferrets

Autor: Jeanette Linnea Tingstedt, Christine Stephen, Christian Risinger, Ola Blixt, Vithiagaran Gunalan, Isik Somuncu Johansen, Anders Fomsgaard, Charlotta Polacek, Ria Lassaunière

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Neuraminidase (NA) accounts for approximately 10-20% of the total glycoproteins on the surface of influenza viruses. It cleaves sialic acids on glycoproteins, which facilitates virus entry into the airways by cleaving heavily glycosylated mucins in m

Externí odkaz: https://doaj.org/article/89b25db981a446e3aeb39dfbcf988956

A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer.

Autor: Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0191872 (2018)

Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function. The resulting modifications induce inf

Externí odkaz: https://doaj.org/article/2db164247c554e8ca49ee8ae87ae240c

Recombinant Glycoprotein E of Varicella Zoster Virus Contains Glycan-Peptide Motifs That Modulate B Cell Epitopes into Discrete Immunological Signatures

Autor: Rickard Nordén, Ebba Samuelsson, Tomas Bergström, Sigvard Olofsson, Carina Sihlbom, Christian Risinger, Göran Larson, Jonas Nilsson, Ola Blixt

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 4, p 954 (2019)
International Journal of Molecular Sciences
Nordén, R, Nilsson, J, Samuelsson, E, Risinger, C, Sihlbom, C, Blixt, O, Larson, G, Olofsson, S & Bergström, T 2019, ' Recombinant Glycoprotein E of Varicella Zoster Virus Contains Glycan-Peptide Motifs That Modulate B Cell Epitopes into Discrete Immunological Signatures ', International Journal of Molecular Sciences (Online), vol. 20, no. 4, 954 . https://doi.org/10.3390/ijms20040954
Volume 20
Issue 4

A recombinant subunit vaccine (Shingrix®
) was recently licensed for use against herpes zoster. This vaccine is based on glycoprotein E (gE) of varicella zoster virus (VZV), the most abundantly expressed protein of VZV, harboring sites for N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25ae7eb161145bb8bb33b6576660929
https://www.mdpi.com/1422-0067/20/4/954

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Autor: Sara Åkerström, Ola Blixt, Janusz T. Paweska, Mehrdad Mousavi-Jazi, Christian Risinger, Sándor Bereczky, Friedemann Weber, Jorma Hinkula, Ali Mirazimi, Caroline Vernersson, Helen Karlberg, Eva Wattrang, Alejandro Brun, Petrus Jansen van Vuren, Gunnel Lindegren, Stephanie Devignot

Publikováno v: Journal of Virology
Hinkula, J, Devignot, S, Åkerström, S, Karlberg, H, Wattrang, E, Bereczky, S, Mousavi-Jazi, M, Risinger, C W, Lindegren, G, Vernersson, C, Paweska, J, van Vuren, P J, Blixt, K O, Brun, A, Friedemann, W & Mirazimi, A 2017, ' Immunization with DNA plasmids coding for crimean-congo hemorrhagic fever virus capsid and envelope proteins and/or virus-like particles induces protection and survival in challenged mice ', Journal of Virology, vol. 91, no. 10, e02076-16 . https://doi.org/10.1128/JVI.02076-16
Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
INIA: Repositorio de Resultados de Investigación del INIA

Crimean-Congo hemorrhagic fever virus (CCHFV) is a bunyavirus causing severe hemorrhagic fever disease in humans, with high mortality rates. The requirement of a high-containment laboratory and the lack of an animal model hampered the study of the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324e47c33f4772dc2d66758a860b16e3
http://europepmc.org/articles/PMC5411611

Synthesis of Oligo-(alkyne-triplet)peptide Constructs

Autor: Ola Blixt, Nicolai Stuhr-Hansen, Christian Risinger, Ebbe Engholm

Publikováno v: Organic Letters

Copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click synthesis of an Fmoc-(trispropargyl)amino acid building block for solid phase peptide synthesis (SPPS) of oligo-(trialkyne)peptide constructs is reported. These can carry potentially inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae4e4770a06626d517382cbf8c24af2