Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Christian Rischel"'
Publikováno v:
Journal of Pharmaceutical Sciences.
We describe a new method for screening protein-protein interaction of biopharmaceutical molecules at dilute concentrations to predict development issues at high concentration. The method is based on Asymmetrical Flow Field-Flow Fractionation (AF4) me
Autor:
Peter Thygesen, Charlotta G. Folkesson, Charlotte Wiberg, Henrik S. Ramírez-Andersen, Mats Reslow, Jens Buchardt, Per Franklin Nielsen, Xin Zhao, Nils Langeland Johansen, Johannes Josef Fels, Chen Jianhe, Leif Nørskov-Lauritsen, Christian Rischel, Xia Wenjuan, Jing Su, Carsten Behrens
Publikováno v:
Bioconjugate Chemistry. 29:3129-3143
The present work describes a series of human growth hormone (hGH) albumin binder conjugates with an extended in vivo half-life. A broad range of different conjugates were studied by varying the albumin binder structure and conjugation site. Conjugate
Autor:
Christian Rischel, Dorrit Baunsgaard, A. Henriksen, M. Reza Nejadnik, Wim Jiskoot, Xinsheng Tian
Publikováno v:
Journal of pharmaceutical sciences
Journal of pharmaceutical sciences, 105(11), 3366–3375
Journal of pharmaceutical sciences, 105(11), 3366–3375
Nanoparticle tracking analysis (NTA) has attracted great interest for application in the field of submicron particle characterization for biopharmaceuticals. It has the virtue of direct sample visualization and particle-by-particle tracking, but the
Autor:
Christian Rischel, Henrik Sune Andersen, Johannes Josef Fels, Leif Nørskov-Lauritsen, Nils Langeland Johansen, Carsten Behrens, Peter Thygesen
Publikováno v:
Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 35
Somapacitan is an albumin-binding growth hormone derivative intended for once weekly administration, currently in clinical development for treatment of adult as well as juvenile GH deficiency. Nonclinical in vivo pharmacological characterisation of s
Autor:
Petr V. Konarev, Dmitri I. Svergun, Charlotte Rode Mosbæk, Christian Rischel, Bente Vestergaard
Publikováno v:
Pharmaceutical Research. 29:2225-2235
Concentrated protein formulations are strongly influenced by protein-protein interactions. These can be probed at low protein concentration by e.g. virial coefficients. It was recently suggested that interactions are attractive at short distances and
Autor:
Christian Rischel, Christian Beyschau Andersen, Mauro Manno, Matthias Thorolfsson, Vincenzo Martorana
Publikováno v:
Protein Science. 19:279-290
Using an IgG1 antibody as a model system, we have studied the mechanisms by which multidomain proteins aggregate at physiological pH when incubated at temperatures just below their lowest thermal transition. In this temperature interval, only minor c
Autor:
Christian Rischel, Fabio Librizzi
Publikováno v:
Protein Science. 14:3129-3134
When subjected to acidic conditions and high temperature, insulin is known to produce fibrils that display the common properties of disease amyloids. Thus, clarifying the mechanisms of insulin fibrillation can help the general understanding of amyloi
Publikováno v:
Journal of Physics: Condensed Matter. 15:S1725-S1735
In order to improve the understanding of the diffusive chain movements leading to protein folding, we have studied microsecond conformational fluctuations in denatured yeast cytochrome c by fluorescence correlation spectroscopy (FCS). We show that em
Autor:
J. C. Gauthier, Ingo Uschmann, Antoine Rousse, E. Förster, J. P. Geindre, D Hulin, Christian Rischel, P. Audebert, S. Fourmaux
Publikováno v:
Measurement Science and Technology
Measurement Science and Technology, IOP Publishing, 2001, 12 (11), pp.1841. ⟨10.1088/0957-0233/12/11/312⟩
Measurement Science and Technology, 2001, 12 (11), pp.1841. ⟨10.1088/0957-0233/12/11/312⟩
ResearcherID
Measurement Science and Technology, IOP Publishing, 2001, 12 (11), pp.1841. ⟨10.1088/0957-0233/12/11/312⟩
Measurement Science and Technology, 2001, 12 (11), pp.1841. ⟨10.1088/0957-0233/12/11/312⟩
ResearcherID
International audience; The recent development of ultrafast x-ray sources makes conceivable the analysis of subpicosecond transient structures in physics, biology and chemistry. This paper focuses on the laser-produced plasma technique. Mainly on the
Autor:
Jacques Breton, Michael R. Jones, Christian Rischel, Justin P. Ridge, Marten H. Vos, Jean-Louis Martin
Publikováno v:
Photosynthesis Research. 55:181-187
Low temperature absorption and linear dichroism (LD) measurements were performed on oriented membranes containing wild type Rhodobacter sphaeroides reaction centers, a mutant reaction center with the change Phe M197 to Arg (FM197R), and a double muta