Výsledky vyhledávání - "Christian Renault"

The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives

Autor: F. Marquis, C. Gueremy, Christian Renault, G. Le Fur, Marie-Christine Dubroeucq, F. Imbault, N. Mitrani, Andre Uzan

Publikováno v: Neuropharmacology. 23:169-173

Summary Two epimer quinoline derivatives, PK 5078 and PK 7059, have been shown to be potent at releasing 5-HT from blood platelets. Moreover PK 5078 was also a potent and selective inhibitor of the uptake of 5-HT, being about 20 times as active as cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa3cc8e124f10d3ac08e8e850241e0ba
https://doi.org/10.1016/s0028-3908(84)80010-6

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Histidine modification with diethylpyrocarbonate induces a decrease in the binding of an antagonist, PK 11195, but not of an agonist, R05–4864, of the peripheral benzodiazepine receptors

Autor: J. Benavides, G. Le Fur, C. Gueremy, T. Phan, Andre Uzan, C. Tur, Christian Renault, Marie-Christine Dubroeucq, F. Begassat

Publikováno v: Life Sciences. 35:1249-1256

[3H]PK 11195 binding to peripheral type benzodiazepine binding sites in kidney membranes is inhibited by the histidine blocking agent diethylpyrocarbonate. This reagent irreversibly decreases the Bmax for [3H]PK 11195 without affecting the affinity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa0dd8fc833fd9a69ed44dfad7e6b3e1
https://doi.org/10.1016/0024-3205(84)90095-x

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Opposite effects of an agonist, R05-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice

Autor: J. Benavides, Andre Uzan, Christian Renault, Marie-Christine Dubroeucq, D.E. Allam, C. Gueremy, Francoise Guilloux, J. Mizoule, G. Le Fur

Publikováno v: Life Sciences. 34:2613-2620

Two compounds with high affinity for the "peripheral type" benzodiazepine binding sites, PK 11195 (an isoquinoline derivative) and RO5-4864 (a benzodiazepine derivative) can modify the sensitivity of DBA/2J mice to audiogenic seizures. RO5-4864 (1-15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7060cd1796df1fd7de0773a01c3f8c01
https://doi.org/10.1016/0024-3205(84)90048-1

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Stereoselective inhibition of the binding of [3H]PK 11195 to peripheral-type benzodiazepine binding sites by a quinolinepropanamide derivative

Autor: Nadine Vaucher, Adam Doble, Claude Gueremy, Philippe Bertrand, Marie-Christine Dubroeucq, J. Benavides, Christian Renault, Andre Uzan, Gérard Le Fur, Djamal Allam, Francoise Guilloux

Publikováno v: European Journal of Pharmacology. 128:269-272

The specific binding of [3H]PK 11195 to the peripheral-type benzodiazepine binding site is inhibited by the 1-enantiomer of N,N-diethyl-α-methyl-2-phenyl-4-quinolinepropanamide ((−)Q1) but not by its d-enantiomer ((+)Q1). (−)Q1 inhibited [3H]PK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed962d41106bf6de847d398626f5592d
https://doi.org/10.1016/0014-2999(86)90776-4

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Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-n-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide

Autor: J. Benavides, A. Flamier, F. Imbault, Christian Renault, Marie-Christine Dubroeucq, C. Gueremy, Andre Uzan, G. Le Fur, Nadine Vaucher, M.L. Perrier

Publikováno v: Life Sciences. 32:1849-1856

Peripheral type of benzodiazepine binding sites were labelled in the kidney, the heart and the brain with [ 3 H] R05-4864 following intravenous injection in mice. The regional distribution of this in vivo binding parallels the in vitro binding: heart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8216758d057998b3f426d70f746af363
https://doi.org/10.1016/0024-3205(83)90063-2

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Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studies

Autor: G. Le Fur, Nadine Vaucher, J. Benavides, A. Flamier, Marie-Christine Dubroeucq, Andre Uzan, Christian Renault, M.L. Perrier, C. Gueremy

Publikováno v: Life Sciences. 33:449-457

The [3H]PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinolinecarboxamide, binding sites in rat cardiac membranes are saturable, with high affinity, specific GABA-independent and correspond to the peripheral type of benzodiazepine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed011948ab679ae514cbcbcfa636e058
https://doi.org/10.1016/0024-3205(83)90794-4

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PK 11195, an antagonist of peripheral type benzodiazepine receptors, modulates BAY K8644 sensitive but not β- or H2-receptor sensitive voltage operated calcium channels in the guinea pig heart

Autor: Gervais Neliat, G. Le Fur, C. Gueremy, Marie-Christine Dubroeucq, Adam Doble, Andre Uzan, T. Carriot, M. Mestre, Christian Renault

Publikováno v: Life Sciences. 39:329-339

In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 × 10 −7 M to 3 × 10 −6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c9d6fbdf21dd7f7d55743e7f25b3ab
https://doi.org/10.1016/0024-3205(86)90651-x

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Partial Purification and Pharmacology of Peripheral-Type Benzodiazepine Receptors

Autor: A. Doble, Christian Renault, Andre Uzan, Jean Menager, C. Gueremy, G. Le Fur, F. Begassat, Marie-Christine Dubroeucq, O. Ferris, Marie-Claude Burgevin

Publikováno v: Journal of Receptor Research. 7:55-70

This report describes the results obtained with a new photoaffinity ligand for the "peripheral-type" benzodiazepine binding site (PBS), using a digitonin solubilized preparation from rat heart or adrenals. The specific binding activity of the solubil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d33a43dcf32efc4cdb1e3c3dac9eda
https://doi.org/10.3109/10799898709054979

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Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart

Autor: G. Le Fur, Andre Uzan, M. Mestre, Marie-Christine Dubroeucq, C. Belin, C. Gueremy, Christian Renault, T. Carriot, Adam Doble

Publikováno v: Life Sciences. 36:391-400

PK 11195, an antagonist of the peripheral type benzodiazepine receptor, does not affect either the duration of the action potential or the tension of the guinea pig papillary muscle. However, it antagonized the effects of the calcium channel blockers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a380bc738c786aff47aebb43f4e0652
https://doi.org/10.1016/0024-3205(85)90126-2

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