Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christian Reichen"'
Autor:
Ilaria Saltarella, Alexander Link, Aurelia Lamanuzzi, Christian Reichen, Joanna Robinson, Concetta Altamura, Assunta Melaccio, Antonio Giovanni Solimando, Roberto Ria, Maria Addolorata Mariggiò, Angelo Vacca, Maria Antonia Frassanito, Jean-François Desaphy
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116877- (2024)
Multiple myeloma (MM) progression is closely dependent on cells in the bone marrow (BM) microenvironment, including fibroblasts (FBs) and immune cells. In their BM niche, MM cells adhere to FBs sustaining immune evasion, drug resistance and the undet
Externí odkaz:
https://doaj.org/article/d806c662dad3406092a021c77cd7d934
Autor:
Andreas Bosshart, Stephan Wullschleger, Martin Behe, Alain Blanc, Stefan Imobersteg, Alexandra Neculcea, Jacqueline Blunschi, Liridon Abduli, Sarah Schütz, Julia Wolter, Christian Reichen, Amelie Croset, Alessandra Villa, Christian Lizak, Anne Goubier, Roger Schibli, Daniel Steiner
Publikováno v:
Cancer Research. 83:5037-5037
The development of effective radioligand therapeutics (RLTs) is frequently hampered by the lack of high-quality targeting agents that selectively deliver radioactive payloads to the site of disease while sparing healthy tissues. Antibodies can have h
Autor:
Matteo Bianchi, Christian Reichen, Stefanie Fischer, Yvonne Grübler, Aline Eggenschwiler, Rajlakshmi Marpakwar, Thamar Looser, Patricia Spitzli, Christel Herzog, Denis Villemagne, Yvonne Kaufmann, Alienor Auge, Martin Hänggi, Waleed Ali, Tamara Lekishvili, Teresa Frasconi, Stephan Wullschleger, Christof Zitt, Marco Franchini, Amelie Croset, Randall Watson, Vladimir Kirkin, Ursina Luethi, Adrian Ochsenbein, Carsten Riether, Daniel Steiner, Nicolas Leupin, Anne Goubier
Publikováno v:
Blood. 140:2251-2252
Autor:
Christian Reichen, Franziska Zosel, Benjamin Schuler, Andreas Plückthun, Patrick Ernst, Daniel Nettels
Publikováno v:
ACS Chemical Biology
Peptides play an important role in intermolecular interactions and are frequent analytes in diagnostic assays, also as unstructured, linear epitopes in whole proteins. Yet, due to the many different sequence possibilities even for short peptides, cla
Autor:
Sylvia Rothenberger, Daniel L. Hurdiss, Marcel Walser, Francesca Malvezzi, Jennifer Mayor, Sarah Ryter, Hector Moreno, Nicole Liechti, Andreas Bosshart, Chloe Iss, Valérie Calabro, Andreas Cornelius, Tanja Hospodarsch, Alexandra Neculcea, Thamar Looser, Anja Schlegel, Simon Fontaine, Denis Villemagne, Maria Paladino, Yvonne Kaufmann, Doris Schaible, Iris Schlegel, Dieter Schiegg, Christof Zitt, Gabriel Sigrist, Marcel Straumann, Feyza Sacarcelik, Julia Wolter, Marco Comby, Julia M. Adler, Kathrin Eschke, Mariana Nascimento, Azza Abdelgawad, Achim D. Gruber, Judith Bushe, Olivia Kershaw, Heyrhyoung Lyoo, Chunyan Wang, Wentao Li, Ieva Drulyte, Wenjuan Du, H. Kaspar Binz, Rachel Herrup, Sabrina Lusvarghi, Sabari Nath Neerukonda, Russell Vassell, Wei Wang, Susanne Mangold, Christian Reichen, Filip Radom, Charles G. Knutson, Kamal K. Balavenkatraman, Krishnan Ramanathan, Seth Lewis, Randall Watson, Micha A. Haeuptle, Alexander Zürcher, Keith M. Dawson, Daniel Steiner, Carol D. Weiss, Patrick Amstutz, Frank J.M. van Kuppeveld, Michael T. Stumpp, Berend-Jan Bosch, Olivier Engler, Jakob Trimpert
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has so far infected more than 160 million people globally, and continues to undergo genomic evolution. Emerging SARS-CoV-2 variants show increased infectivity and may lead to resistance again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f1f2736c93ea65c719bd52f33d283d1
https://doi.org/10.1101/2021.02.03.429164
https://doi.org/10.1101/2021.02.03.429164
Autor:
Yvonne Grübler, Mirela Matzner, Carsten Riether, Matteo Bianchi, Aline Eggenschwiler, Vladimir Kirkin, Kyriaki Ioannou, Waleed Ali, Simone Ragusa, Stefanie Fischer, Bernd Schlereth, Alienor Auge, Christian Reichen, Denis Villemagne, Adrian F. Ochsenbein, Jennifer Krieg, Anne Goubier, Martin Hänggi, Daniel Steiner, Patricia Spitzli, Thamar Looser, Ursina Luethi, Marco Franchini, Christel Herzog, Nina Reschke, Yvonne Kaufmann
Publikováno v:
Blood. 138:1164-1164
AML is driven by leukemic stem cells (LSC) that resist conventional chemotherapies and remain unaffected in their niche, continually replenishing circulating blast cells. We postulated that an avidity-engineered CD3 engaging DARPin ® (Designed Ankyr
Autor:
Bernd Schlereth, Alexandra Neculcea, Nicole Bassler, Daniel Steiner, Sebastian Grimm, Nina Reschke, Yvonne Gruebler, Thamar Looser, Laura Jeanbart, Jennifer Krieg, Matteo Bianchi, Patricia Schildknecht, Tanja Hospodarsch, Christian Reichen
Publikováno v:
Cancer Research. 81:525-525
Purpose: The medical need due to high mortality in acute myeloid leukemia (AML) remains high, and the treatment of relapsed or refractory AML continues to be therapeutically challenging. MYLOTARG, the only approved anti-CD33 antibody drug conjugate (
Autor:
Laurent Juglair, Patricia Schildknecht, Ivana Tosevski, Michael T. Stumpp, Keith M. Dawson, Alexander Link, Camila de Almeida, Jörg Herbst, Elmar vom Baur, Niina Veitonmäki, Christof Zitt, Victor Levitsky, Joanna Robinson, Hong Ji, Guy Lemaillet, Heidi Poulet, Rik de Greef, Christian Reichen
Publikováno v:
Cancer Research. 80:2273-2273
Following the clinical success of checkpoint inhibitors, cancer immunotherapy is rapidly expanding into combination treatments to enhance response rates and duration. Engagement of co-stimulatory molecules from the tumor necrosis factor receptor (TNF
Autor:
Daniel Nettels, Patrick Ernst, Peer R. E. Mittl, Simon Hansen, Benjamin Schuler, Sebastian L. B. König, Christina Ewald, Christian Reichen, Andreas Plückthun
Publikováno v:
Journal of structural biology. 201(2)
Designed armadillo repeat proteins (dArmRPs) were developed to create a modular peptide binding technology where each of the structural repeats binds two residues of the target peptide. An essential prerequisite for such a technology is a dArmRP geom
Publikováno v:
Protein Science. 23:1572-1583
Designed armadillo repeat proteins (dArmRP) are promising modular proteins for the engineering of binding molecules that recognize extended polypeptide chains. We determined the structure of a dArmRP containing five internal repeats and 3rd generatio