Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christian R. Nelson"'
Autor:
Bonnibelle K Leeds, Katelyn F Kostello, Yuna Y Liu, Christian R Nelson, Sue Biggins, Charles L Asbury
Publikováno v:
eLife, Vol 12 (2023)
During mitosis, kinetochore-attached microtubules form bundles (k-fibers) in which many filaments grow and shorten in near-perfect unison to align and segregate each chromosome. However, individual microtubules grow at intrinsically variable rates, w
Externí odkaz:
https://doaj.org/article/4802c6d4179049c2934ea6eb8091dffd
Publikováno v:
Molecular Biology of the Cell
Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume, and cell fate. We show that the conserved AAA-ATPase PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an inactive o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a294f80aba86c4a0226949d3d6eec8
http://europepmc.org/articles/PMC7550697
http://europepmc.org/articles/PMC7550697
Dividing cells detect and correct erroneous kinetochore-microtubule attachments during mitosis, thereby avoiding chromosome mis-segregation. Most studies of this process have focused on the Aurora B kinase, which phosphorylates microtubule-binding el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3013cdad86daac44fac61bd0b9579a4d
https://doi.org/10.1101/2021.04.25.441339
https://doi.org/10.1101/2021.04.25.441339
Autor:
Bungo Akiyoshi, Christian R Nelson, Nicole Duggan, Steven Ceto, Jeffrey A Ranish, Sue Biggins
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003216 (2013)
The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of duplicated chromosomes. More than 60 components make up the budding yeast kinetochore, including inner kinetochore proteins that bin
Externí odkaz:
https://doaj.org/article/22f2b1eaa235479d9c8af64b74a803a9
Spindle checkpoint strength is dictated by three criteria: the number of unattached kinetochores, cell volume and cell fate. We show that the conserved AAA-ATPase, PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e339366828cd69aac07df09caba7baf
https://doi.org/10.1101/389080
https://doi.org/10.1101/389080
Summary The conserved factor Shugoshin is dispensable in C. elegans for the two-step loss of sister chromatid cohesion that directs the proper segregation of meiotic chromosomes. We show that the C. elegans ortholog of Shugoshin, SGO-1, is required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89408782c07c629d9ab2491146e5280
The kinetochore is a macromolecular complex that controls chromosome segregation and cell cycle progression. When sister kinetochores make bioriented attachments to microtubules from opposite poles, the spindle checkpoint is silenced. Biorientation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b188050d0bace943a87a4d805dac748c
https://europepmc.org/articles/PMC5110999/
https://europepmc.org/articles/PMC5110999/
The kinetochore is a macromolecular complex that controls chromosome segregation and cell cycle progression. When sister kinetochores make bioriented attachments to microtubules from opposite poles, the spindle checkpoint is silenced. Biorientation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff71003e0e83ed85bc70085147ada7a9
https://ora.ox.ac.uk/objects/uuid:3fcca85f-e652-49b8-bcc6-5a33fac7dcf4
https://ora.ox.ac.uk/objects/uuid:3fcca85f-e652-49b8-bcc6-5a33fac7dcf4
Publikováno v:
Genetics. 183:1591-1595
Phosphorylation of the Ndc80 kinetochore protein by the Ipl1/Aurora B kinase reduces its microtubule binding activity in vitro. We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e322f5559696e6fe4165b562c2b878b2
https://doi.org/10.1534/genetics.109.109041
https://doi.org/10.1534/genetics.109.109041