Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Christian R. Fagre"'
Autor:
David L Cookmeyer, Emily S Winesett, Bashkim Kokona, Adam R Huff, Sabina Aliev, Noah B Bloch, Joshua A Bulos, Irene L Evans, Christian R Fagre, Kerilyn N Godbe, Maryna Khromava, Daniel M Konstantinovsky, Alexander E Lafrance, Alexandra J Lamacki, Robert C Parry, Jeanne M Quinn, Alana M Thurston, Kathleen J S Tsai, Aurelio Mollo, Max J Cryle, Robert Fairman, Louise K Charkoudian
Publikováno v:
PLoS Biology, Vol 15, Iss 11, p e2003145 (2017)
How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate origina
Externí odkaz:
https://doaj.org/article/16747030f29d460aaae187a6d7c0dcd0
Autor:
Andrew O. Giacomelli, William C. Hahn, Julia Bauman, Orit Rozenblatt-Rosen, Andrew J. Aguirre, Lan Nguyen, Jesse S. Boehm, Emily K Shea, Seav Huong Ly, Pratiksha I. Thakore, Danielle Dionne, Alice H. Berger, Celeste Diaz, James T. Neal, Livnat Jerby-Arnon, Christian R. Fagre, Aviv Regev, Mariam Mounir Mosaad, Oana Ursu
Genome sequencing studies have identified millions of somatic variants in cancer, but their phenotypic impact remains challenging to predict. Current experimental approaches to distinguish between functionally impactful and neutral variants require c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f573fe66aaf4affc6af462a900eb606
https://doi.org/10.1101/2020.11.16.383307
https://doi.org/10.1101/2020.11.16.383307
Autor:
Anika Gupta, Heiko Horn, Kalliopi Tsafou, James T. Neal, Kasper Lage, Nadine Fornelos, Christian R. Fagre
Genes required for tumor proliferation and survival (dependencies) are challenging to predict from cancer genome data, but are of high therapeutic value. We developed an algorithm (network purifying selection [NPS]) that aggregates weak signals of pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83a692bbae2aefdceb2d5d6f47a61391
https://doi.org/10.1101/2020.08.27.270520
https://doi.org/10.1101/2020.08.27.270520
Autor:
Annabel K Sangree, Christian R. Fagre, Luke W. Koblan, Peter C DeWeirdt, David R. Liu, John G. Doench, Ruth E Hanna, Audrey L Griffith, Zsofia Szegletes, Mudra Hegde, Marissa N Feeley, Yossef Baidi, James T. Neal, Kendall R Sanson
Understanding the functional consequences of single-nucleotide variants is critical to uncovering the genetic underpinnings of diseases, but technologies to characterize variants are limiting. Here we leverage CRISPR-Cas9 cytosine base editors in poo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b0689d30e05af1f97fdd9d246d60005
https://doi.org/10.1101/2020.05.17.100818
https://doi.org/10.1101/2020.05.17.100818
Autor:
David R. Liu, Marissa N Feeley, Peter C DeWeirdt, Mudra Hegde, Luke W. Koblan, Audrey L Griffith, John G. Doench, James T. Neal, Zsofia Szegletes, Annabel K Sangree, Ruth E Hanna, Yossef Baidi, Kendall R Sanson, Christian R. Fagre
Publikováno v:
Cell. 184:1064-1080.e20
Understanding the functional consequences of single-nucleotide variants is critical to uncovering the genetic underpinnings of diseases, but technologies to characterize variants are limiting. Here, we leverage CRISPR-Cas9 cytosine base editors in po
Autor:
Kathleen J. S. Tsai, Louise K. Charkoudian, Emily S. Winesett, Sabina Aliev, Alexandra J. Lamacki, Alexander E. Lafrance, Adam R. Huff, David L. Cookmeyer, Joshua A. Bulos, Christian R. Fagre, Maryna Khromava, Kerilyn N. Godbe, Max J. Cryle, Noah B. Bloch, Robert Fairman, Irene L. Evans, Alana M. Thurston, Jeanne M. Quinn, Bashkim Kokona, Robert C. Parry, Aurelio Mollo, Daniel M. Konstantinovsky
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 11, p e2003145 (2017)
PLoS Biology, Vol 15, Iss 11, p e2003145 (2017)
How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate origina