Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

Autor: Thomas H. Vanderford, S. Abigail Smith, Lavinia Franchitti, Rae Ann Spagnuolo, J. Victor Garcia, John Lee, Christian R. Aguilera-Sandoval, Maud Mavigner, Guido Silvestri, Ann Chahroudi, Steven E. Bosinger, Diane G. Carnathan, Julia Bergild McBrien, Jacob D. Estes, Angela Wahl, Martina Kovarova, Jeffrey D. Lifson, Kathleen Busman-Sahay, William O. Thayer, Cynthia A. Derdeyn, Deanna A. Kulpa, Gregory K. Tharp, Jeffrey T. Safrit, Erick White, David M. Margolis, Barbara Cervasi, Hasse Walum, Mirko Paiardini

Publikováno v: Nature

Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain replication-competent virus1–4. Here, to better understand the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f61b393950b71f3b34763d53c67087

Inferring tumor subclonality

Autor: Wes Sanders, Ralph S. Baric, Heather A. Vincent, Angela Wahl, Nathaniel J. Moorman, J. Victor Garcia, Erik M. Lenarcic, Allison Boone, Miriam Braunstein, Christian R. Aguilera-Sandoval, Yinyan Xu, Nilu Goonetilleke, Paul A. Dayton, William H. Hildebrand, Maria Abad Fernandez, Chandrav De, Adam S. Cockrell, Claire Johnson, Raymond J. Pickles, Nathaniel J. Schramm, Laura Rank, Isabel G. Newsome, Rachel A. Cleary

Publikováno v: Nature Biotechnology
Nature biotechnology

A major limitation of current humanized mouse models is that they primarily enable the analysis of human-specific pathogens that infect hematopoietic cells. However, most human pathogens target other cell types, including epithelial, endothelial and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc55f8e20e208959483e150be43a478b
https://doi.org/10.1038/s41592-020-0777-0

Supranormal thymic output up to 2 decades after HIV-1 infection

Autor: Maria Ines Boechat, Paige Cooper, Paul Krogstad, Pietro Lovato, Otto O. Yang, Christian R. Aguilera-Sandoval, Christina M. Ramirez, Nebojsa Jojic, Diana Y. Chen, Joseph A. Church, Marvin Belzer, Jun Zuo

Publikováno v: AIDS (London, England), vol 30, iss 5
Aguilera-Sandoval, CR; Yang, OO; Jojic, N; Lovato, P; Chen, DY; Boechat, MI; et al.(2016). Supranormal thymic output up to 2 decades after HIV-1 infection. AIDS, 30(5), 701-711. doi: 10.1097/QAD.0000000000001010. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6rf4d7m6

Supranormal thymic output up to 2 decades after HIV-1 infection Christian R. Aguilera-Sandoval a , Otto O. Yang a,b , Nebojsa Jojic c , Pietro Lovato d , Diana Y. Chen a , Maria Ines Boechat a , Paige Cooper a , Jun Zuo a , Christina Ramirez e , Marv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee437ea895946d47d8d6ae75f46fbc3
https://escholarship.org/uc/item/6rf4d7m6

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells

Autor: Gregory Bristol, Otto O. Yang, Jerome A. Zack, Christian R. Aguilera-Sandoval, Scott G. Kitchen, Valerie Rezek, Sohn G. Kim, Bernard Levin, Arumugam Balamurugan

Publikováno v: PLoS Pathogens, Vol 8, Iss 4, p e1002649 (2012)
PLoS Pathogens
PLoS pathogens, vol 8, iss 4

The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling viral replication in vivo, but ultimately fails in its ability to eradicate the virus. Our intent in these studies is to develop ways to enhance and restore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd49d984455ba017054aff44902d16b
https://doi.org/10.1371/journal.ppat.1002649