Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report

Autor: Jinyi Zhang, Christian R. Juhl, Louise Hylten-Cavallius, Morten Salling-Olsen, Allan Linneberg, Jens Juul Holst, Torben Hansen, Jørgen K. Kanters, Signe S. Torekov

Publikováno v: BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-5 (2020)

Abstract Background The voltage-gated potassium channel Kv7.1 encoded by KCNQ1 is located in both cardiac myocytes and insulin producing beta cells. Loss-of-function mutations in KCNQ1 causes long QT syndrome along with glucose-stimulated hyperinsuli

Externí odkaz: https://doaj.org/article/69ea9bc057dc4782a9935440cb68bf8d

A randomised, double-blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women

Autor: Christian R. Juhl, Josephine Burgdorf, Cecilie Knudsen, Anniek F. Lubberding, Simon Veedfald, Jonas L. Isaksen, Bolette Hartmann, Ruth Frikke‐Schmidt, Thomas Mandrup‐Poulsen, Jens J. Holst, Jørgen K. Kanters, Signe S. Torekov

Publikováno v: Juhl, C R, Burgdorf, J, Knudsen, C, Lubberding, A F, Veedfald, S, Isaksen, J L, Hartmann, B, Frikke-Schmidt, R, Mandrup-Poulsen, T, Holst, J J, Kanters, J K & Torekov, S S 2023, ' A randomised, double-blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women ', Diabetes, Obesity and Metabolism, vol. 25, no. 1, pp. 98-109 . https://doi.org/10.1111/dom.14851

AIMS: The voltage-gated potassium channel K v 11.1 is important for repolarising the membrane potential in excitable cells such as myocytes, pancreatic α- and β-cells. Moxifloxacin blocks the K v 11.1 channel and increases the risk of hypoglycaemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd513e5bf24dfe3cd103ae0c486c9b90
https://curis.ku.dk/ws/files/329427442/Diabetes_Obesity_Metabolism_2022_Juhl_A_randomized_double_blind_crossover_study_of_the_effect_of_the.pdf

Author response for 'A randomised, double‐blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women'

Autor: null Christian R. Juhl, null Josephine Burgdorf, null Cecilie Knudsen, null Anniek F. Lubberding, null Simon Veedfald, null Jonas L. Isaksen, null Bolette Hartmann, null Ruth Frikke‐Schmidt, null Thomas Mandrup‐Poulsen, null Jens J. Holst, null Jørgen K. Kanters, null Signe S. Torekov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc4ea7c262c0aaf9a52cda4d1ad5d004
https://doi.org/10.1111/dom.14851/v2/response1

Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment:a randomized controlled trial

Autor: Emil Andersen, Christian R Juhl, Emma T Kjøller, Julie R Lundgren, Charlotte Janus, Yasmin Dehestani, Marte Saupstad, Lars R Ingerslev, Olivia M Duun, Simon B K Jensen, Jens J Holst, Bente M Stallknecht, Sten Madsbad, Signe S Torekov, Romain Barrès

Publikováno v: Andersen, E, Juhl, C R, Kjøller, E T, Lundgren, J R, Janus, C, Dehestani, Y, Saupstad, M, Ingerslev, L R, Duun, O M, Jensen, S B K, Holst, J J, Stallknecht, B M, Madsbad, S, Torekov, S S & Barrès, R 2022, ' Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment : a randomized controlled trial ', Human Reproduction, vol. 37, no. 7, pp. 1414–1422 . https://doi.org/10.1093/humrep/deac096

STUDY QUESTION Does diet-induced weight loss improve semen parameters, and are these possible improvements maintained with sustained weight loss? SUMMARY ANSWER An 8-week low-calorie diet-induced weight loss was associated with improved sperm concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0eef71514d6abf7ed23cae393b3286
https://curis.ku.dk/portal/da/publications/sperm-count-is-increased-by-dietinduced-weight-loss-and-maintained-by-exercise-or-glp1-analogue-treatment(8e714f37-9727-44b0-a094-31c99f02e037).html

Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels K

Autor: Anniek F, Lubberding, Christian R, Juhl, Emil Z, Skovhøj, Jørgen K, Kanters, Thomas, Mandrup-Poulsen, Signe S, Torekov

Publikováno v: Acta physiologica (Oxford, England). 234(3)

Voltage-gated potassium (K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2064bf1eb89a1a792d59bebee337e491
https://pubmed.ncbi.nlm.nih.gov/34990074