Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Christian R Geest"'
Autor:
Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp
PDF file - 732K, A. CLL cells were stimulated with CD40L for 72 hrs. After detachment, cells were incubated with 0.1 �M of ABT-737. Protein lysates were probed for Mcl-1, Bfl-1, Noxa and �-actin. B. Densitometric analysis of Mcl-1/ �-actin leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e2fa7bd328fc37344c0fd46b8fa443
https://doi.org/10.1158/1078-0432.22444197
https://doi.org/10.1158/1078-0432.22444197
Autor:
Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp
Purpose: Chronic lymphocytic leukemia (CLL) cells in lymph nodes (LN), from which relapses are postulated to originate, display an antiapoptotic profile in contrast to CLL cells from peripheral blood (PB). The BH3 mimetic ABT-737 antagonizes the anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469e65f6d130cd6a00f3e1c9a3ba0ff0
https://doi.org/10.1158/1078-0432.c.6520092
https://doi.org/10.1158/1078-0432.c.6520092
Autor:
Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp
PDF file - 866K, CLL cells were stimulated with CD40L for 48 hrs. After detachment, cells were incubated with 10 �M or 100 �M fludarabine � Q-VD (12,5 �M), � NAC (5mM). Protein lysates were probed for Noxa, Mcl-1 and �-actin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145ab7fc0d303970a0270593eb0b3a2f
https://doi.org/10.1158/1078-0432.22444194.v1
https://doi.org/10.1158/1078-0432.22444194.v1
Autor:
Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp
PDF file - 986K, A. ABT-737 resistant CLL cells were stimulated with CD40L for 72 hours (n=4). The black line shows apoptosis levels from CLL cells detached from the feeder layer and subsequently treated with different concentrations of ABT-737 (0.00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8472010f825795932f435000aac4d63c
https://doi.org/10.1158/1078-0432.22444206
https://doi.org/10.1158/1078-0432.22444206
Autor:
Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp
PDF file - 620K, CLL cells were stimulated with CD40L for the indicated time (24, 48 and 72 hrs). Western blots of Bfl-1 were quantified with Odyssey software in both ABT-737 sensitive (n=4) and ABT-737 resistant (n=4) CD40-stimulated CLL cells. Bars
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5eb35417fc9c7b9022dcebd19a5987
https://doi.org/10.1158/1078-0432.22444203.v1
https://doi.org/10.1158/1078-0432.22444203.v1
Autor:
Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp
PDF file - 793K, Nucleofection with Noxa siRNA or control siRNA was performed on CLL cells in the presence or absence of the proteasoom inhibitor GSI. Protein lysates were probed for Mcl-1, Noxa and �-actin. As a control, lysates of untransfected C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490a5dc6e16ab554cc08efba89221045
https://doi.org/10.1158/1078-0432.22444200.v1
https://doi.org/10.1158/1078-0432.22444200.v1
Autor:
Rachel Thijssen, Erik Slinger, Katinka Weller, Christian R. Geest, Tim Beaumont, Marinus H.J. van Oers, Arnon P. Kater, Eric Eldering
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
Externí odkaz:
https://doaj.org/article/e9907038c7c64bd1b127d5179c385115
Publikováno v:
Haematologica, Vol 95, Iss 7 (2010)
Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years. Nonetheless, little is curr
Externí odkaz:
https://doaj.org/article/db9368cea2e34e1f877633c9193105df
Publikováno v:
Haematologica, Vol 94, Iss 8 (2009)
Background In patients with myelodysplasia, a general defect in the multipotent stem-cell compartment results in disturbed proliferation and differentiation of the erythroid, megakaryocytic and myeloid lineages. Although a number of genetic defects i
Externí odkaz:
https://doaj.org/article/b13bbb67438749b793e381b5d0ff1f7d
Publikováno v:
Haematologica, Vol 94, Iss 7 (2009)
Background The mammalian target of rapamycin is a conserved protein kinase known to regulate protein synthesis, cell size and proliferation. Aberrant regulation of mammalian target of rapamycin activity has been observed in hematopoietic malignancies
Externí odkaz:
https://doaj.org/article/72dfb16966d74e89b08b19e20e2df463