Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Christian R A Regenbrecht"'
Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures.
Autor:
Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Jens Hoffmann, Melanie Boerries, Reinhold Schäfer, Christian R A Regenbrecht
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008076 (2019)
Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of targeted therapies under conditions capturing in vitro the genetic make-up of heterogeneous and e
Externí odkaz:
https://doaj.org/article/4a7ae2e6be5340cd9102d8eb799ab595
Autor:
Torben Redmer, Yvonne Welte, Diana Behrens, Iduna Fichtner, Dorothea Przybilla, Wasco Wruck, Marie-Laure Yaspo, Hans Lehrach, Reinhold Schäfer, Christian R A Regenbrecht
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e92596 (2014)
Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure and drug resistance. In malignant melanoma, heterogeneity is thought to arise as a consequence of the d
Externí odkaz:
https://doaj.org/article/452934a375834a4fbabd523160e781ad
Autor:
Siyer Roohani, Jürgen Loskutov, Jens Heufelder, Felix Ehret, Lena Wedeken, Manuela Regenbrecht, Rica Sauer, Daniel Zips, Andrea Denker, Antonia M. Joussen, Christian R. A. Regenbrecht, David Kaul
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Despite their heterogeneity, the current standard preoperative radiotherapy regimen for localized high-grade soft tissue sarcoma (STS) follows a one fits all approach for all STS subtypes. Sarcoma patient-derived three-dimensional
Externí odkaz:
https://doaj.org/article/978392af73f847c6a2fee183ae47ad62
Autor:
Ulrike Pfohl, Alina Pflaume, Manuela Regenbrecht, Sabine Finkler, Quirin Graf Adelmann, Christoph Reinhard, Christian R. A. Regenbrecht, Lena Wedeken
Publikováno v:
Cells, Vol 10, Iss 4, p 928 (2021)
Cancer is a multifactorial disease with increasing incidence. There are more than 100 different cancer types, defined by location, cell of origin, and genomic alterations that influence oncogenesis and therapeutic response. This heterogeneity between
Externí odkaz:
https://doaj.org/article/feb5338f28b84f238e56e7373ed660a1
Autor:
Ulrike Pfohl, Jürgen Loskutov, Sanum Bashir, Ralf Kühn, Patrick Herter, Markus Templin, Soulafa Mamlouk, Sergei Belanov, Michael Linnebacher, Florian Bürtin, Marcus Vetter, Christoph Reinhard, Lena Wedeken, Christian R. A. Regenbrecht
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3252
Background: In colorectal cancer (CRC), mutations of genes associated with the TGF-β/BMP signaling pathway, particularly affecting SMAD4, are known to correlate with decreased overall survival and it is assumed that this signaling axis plays a key r
Autor:
Sushmitha Sankarasubramanian, Ulrike Pfohl, Christian R. A. Regenbrecht, Christoph Reinhard, Lena Wedeken
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Pancreatic cancer is one of the deadliest cancers and remains a major unsolved health problem. While pancreatic ductal adenocarcinoma (PDAC) is associated with driver mutations in only four major genes (KRAS, TP53, SMAD4, and CDKN2A), every tumor dif
Autor:
Beate Rau, Guido Gambara, Lena Wedeken, Safak Gül-Klein, Eva Pachmayr, Jens Hoffmann, Ulrike Stein, Bernadette Brzezicha, Andreas Brandl, Mathias Dahlmann, Oliver Popp, Alina Pflaume, Ulrich Keilholz, Christian R. A. Regenbrecht, Philipp Mertins, Caroline Schweiger-Eisbacher, Margarita Mokritzkij, Wolfgang Walther
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 20, Iss 1, Pp 1-8 (2021)
Molecular Cancer, Vol 20, Iss 1, Pp 1-8 (2021)
Autor:
Lena Wedeken, Manuela Regenbrecht, Christian R. A. Regenbrecht, Alina Pflaume, Ulrike Pfohl, Sabine Finkler, Quirin Graf Adelmann, Christoph Reinhard
Publikováno v:
Cells, Vol 10, Iss 928, p 928 (2021)
Cells
Cells
Cancer is a multifactorial disease with increasing incidence. There are more than 100 different cancer types, defined by location, cell of origin, and genomic alterations that influence oncogenesis and therapeutic response. This heterogeneity between
Autor:
Joseph L, Regan, Dirk, Schumacher, Stephanie, Staudte, Andreas, Steffen, Ralf, Lesche, Joern, Toedling, Thibaud, Jourdan, Johannes, Haybaeck, Nicole, Golob-Schwarzl, Dominik, Mumberg, David, Henderson, Balázs, Győrffy, Christian R A, Regenbrecht, Ulrich, Keilholz, Reinhold, Schäfer, Martin, Lange
Publikováno v:
iScience. 25(7)
Recent evidence demonstrates that colon cancer stem cells (CSCs) can generate neurons that synapse with tumor innervating fibers required for tumorigenesis and disease progression. Greater understanding of the mechanisms that regulate CSC driven tumo
Autor:
Johannes Haybaeck, Andreas Steffen, Stephanie Staudte, Dirk Schumacher, Ulrich Keilholz, Christian R. A. Regenbrecht, Nicole Golob-Schwarzl, Reinhold Schäfer, Caroline Schweiger, Hans Lehrach, Joseph L. Regan, David Henderson, Martin Lange, Dominik Mumberg
Publikováno v:
Cell Reports
Cell Reports, Vol 21, Iss 10, Pp 2813-2828 (2017)
Cell Reports, Vol 21, Iss 10, Pp 2813-2828 (2017)
Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs