Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christian Proepper"'
Autor:
Sri Hari Krishna Vellanki, Andreas Grabrucker, Stefan Liebau, Christian Proepper, Adriana Eramo, Veit Braun, Tobias Boeckers, Klaus-Michael Debatin, Simone Fulda
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 8, Pp 743-752 (2009)
Because evasion of apoptosis can cause radioresistance of glioblastoma, there is a need to design rational strategies that counter apoptosis resistance. In the present study, we investigated the potential of targeting the antiapoptotic protein XIAP f
Externí odkaz:
https://doaj.org/article/3438c15471e4408e81242cccd3ebf493
Autor:
Bjoern von Einem, Anke Wahler, Tobias Schips, Alberto Serrano-Pozo, Christian Proepper, Tobias M Boeckers, Angelika Rueck, Thomas Wirth, Bradley T Hyman, Karin M Danzer, Dietmar R Thal, Christine A F von Arnim
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129047 (2015)
Proteolytic processing of amyloid-β precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) is the initial step in the production of amyloid beta (Aβ), which accumulates in senile plaques in Alzheimer's disease (AD). Essential for this c
Externí odkaz:
https://doaj.org/article/22b8744c88d84df4afb3d006d8a82a9f
Autor:
Leonhard Linta, Marianne Stockmann, Qiong Lin, André Lechel, Christian Proepper, Tobias M. Boeckers, Alexander Kleger, Stefan Liebau
Publikováno v:
Stem Cells International, Vol 2013 (2013)
Ion channels are involved in a large variety of cellular processes including stem cell differentiation. Numerous families of ion channels are present in the organism which can be distinguished by means of, for example, ion selectivity, gating mechani
Externí odkaz:
https://doaj.org/article/22af6c40ef2e4745b80ca22015e2510b
Autor:
Claire S Leblond, Jutta Heinrich, Richard Delorme, Christian Proepper, Catalina Betancur, Guillaume Huguet, Marina Konyukh, Pauline Chaste, Elodie Ey, Maria Rastam, Henrik Anckarsäter, Gudrun Nygren, I Carina Gillberg, Jonas Melke, Roberto Toro, Beatrice Regnault, Fabien Fauchereau, Oriane Mercati, Nathalie Lemière, David Skuse, Martin Poot, Richard Holt, Anthony P Monaco, Irma Järvelä, Katri Kantojärvi, Raija Vanhala, Sarah Curran, David A Collier, Patrick Bolton, Andreas Chiocchetti, Sabine M Klauck, Fritz Poustka, Christine M Freitag, Regina Waltes, Marnie Kopp, Eftichia Duketis, Elena Bacchelli, Fiorella Minopoli, Liliana Ruta, Agatino Battaglia, Luigi Mazzone, Elena Maestrini, Ana F Sequeira, Barbara Oliveira, Astrid Vicente, Guiomar Oliveira, Dalila Pinto, Stephen W Scherer, Diana Zelenika, Marc Delepine, Mark Lathrop, Dominique Bonneau, Vincent Guinchat, Françoise Devillard, Brigitte Assouline, Marie-Christine Mouren, Marion Leboyer, Christopher Gillberg, Tobias M Boeckers, Thomas Bourgeron
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002521 (2012)
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects
Externí odkaz:
https://doaj.org/article/03767000fd224a4884ce09193bcfd6c7
Autor:
Stefan Liebau, Julie Steinestel, Leonhard Linta, Alexander Kleger, Alexander Storch, Michael Schoen, Konrad Steinestel, Christian Proepper, Juergen Bockmann, Michael J Schmeisser, Tobias M Boeckers
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18148 (2011)
BackgroundThe stabilization or regulated reorganization of the actin cytoskeleton is essential for cellular structure and function. Recently, we could show that the activation of the SK3-channel that represents the predominant SK-channel in neural st
Externí odkaz:
https://doaj.org/article/0e0ea8c5a24d4b38b35ba8be100c8676
Autor:
Christian Proepper, Konrad Steinestel, Michael J Schmeisser, Jutta Heinrich, Julie Steinestel, Juergen Bockmann, Stefan Liebau, Tobias M Boeckers
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27045 (2011)
BACKGROUND: Abelson-interacting protein 1 (Abi-1) plays an important role for dendritic branching and synapse formation in the central nervous system. It is localized at the postsynaptic density (PSD) and rapidly translocates to the nucleus upon syna
Externí odkaz:
https://doaj.org/article/8f45e73726fe4835acf2ea593895ab9d
Autor:
Débora Garrido, Stefania Beretta, Stefanie Grabrucker, Helen Friedericke Bauer, David Bayer, Carlo Sala, Chiara Verpelli, Francesco Roselli, Juergen Bockmann, Christian Proepper, Alberto Catanese, Tobias M. Boeckers
Publikováno v:
Molecular psychiatry 27(12), 4994-5006 (2022). doi:10.1038/s41380-022-01756-8
Members of the Shank protein family are master scaffolds of the postsynaptic architecture and mutations within the SHANK genes are causally associated with autism spectrum disorders (ASDs). We generated a Shank2-Shank3 double knockout mouse that is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdd439bd2ea247f1ff0ca2a0e2c6dcb
https://pub.dzne.de/record/165245
https://pub.dzne.de/record/165245
Autor:
Raphael, Hesse, Bjoern, von Einem, Franziska, Wagner, Patricia, Bott, Daniel, Schwanzar, Rosemary J, Jackson, Karl Josef, Föhr, Ludwig, Lausser, Katja S, Kroker, Christian, Proepper, Paul, Walther, Hans A, Kestler, Tara L, Spires-Jones, Tobias, Boeckers, Holger, Rosenbrock, Christine A F, von Arnim
Publikováno v:
Experimental neurology. 304
One major pathophysiological hallmark of Alzheimer's disease (AD) is senile plaques composed of amyloid β (Aβ). In the amyloidogenic pathway, cleavage of the amyloid precursor protein (APP) is shifted towards Aβ production and soluble APPβ (sAPP
Autor:
Noreen Kanwal, Christian Proepper, Sonja Halbedl, Anna Dolnik, Susanne J. Kühl, Sarah Mackert, Michael J. Schmeisser, Michael Schoen, Juergen Bockmann, Tobias M. Boeckers
Publikováno v:
Journal of Neurochemistry. 136:28-35
Rap GTPase-activating proteins (RapGAPs) are essential for synaptic function as they tightly regulate synaptic Rap signaling. Among the most abundant synaptic RapGAPs in brain are the Spine-associated RapGAPs (SPARs) Sipa1l1/SPAR and Sipa1l2/SPAR2, w
Publikováno v:
Neuroscience. 261:133-143
The postsynaptic density is an electron dense meshwork composed of a variety of molecules facilitating neuronal signal transmission. ProSAP2/Shank3 represents a crucial player at postsynaptic sites, assembling large multimeric platforms and anchoring