Výsledky vyhledávání - "Christian Pistore"

DNMT3A epigenetically regulates key microRNAs involved in epithelial-to-mesenchymal transition in prostate cancer

Autor: Ilaria Castiglioni, Federica Babbio, Lina Sabatino, Francesca Precazzini, Monica Mancini, Margherita Grasso, Michela A. Denti, Michele Zocchi, Valentina Zanetti, Ian Marc Bonapace, Alessandro Weisz, Valerio Licursi, Valerio Del Vescovo, Francesca Rizzo, Maria Giovanna De Marino, Livio Muccillo, Christian Pistore, Paola Chiarugi, Giorgio Giurato

Publikováno v: Carcinogenesis. 42(12)

Epithelial-to-mesenchymal transition (EMT) is involved in prostate cancer (PCa) metastatic progression, and its plasticity suggests epigenetic implications. Deregulation of DNA methyltransferases (DNMTs) and several microRNAs (miRNAs) plays a relevan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bd0c4c7ace3b02d4f317ec74092118
https://pubmed.ncbi.nlm.nih.gov/34687205

Zobrazit plný text záznamu

UHRF1 regulates CDH1 via promoter associated non-coding RNAs in prostate cancer cells

Autor: Monica Mancini, Filippo Macchi, Christian Pistore, Sara Cogliati, Ian Marc Bonapace, Anne-Catherine Dock-Bregeon, Elena Magnani, Martina Mandruzzato, Vanessa Veronica Lomazzi

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861:258-270

Non-coding RNAs (ncRNAs) transcribed from the promoter and the downstream region can affect the expression of the corresponding coding genes. It has been shown that sense-directed ncRNAs arising from the promoter region of the E-cadherin gene (CDH1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75e041b1aa4076a1382300f47a07c06
https://doi.org/10.1016/j.bbagrm.2018.02.006

Zobrazit plný text záznamu

DNA methylation variations are required for reversible epithelial-to-mesenchimal transition induced by cancer-associated fibroblasts in prostate cancer cells

Widespread genome hypo-methylation and promoter hyper-methylation of epithelium-specific genes are hallmarks of stable epithelial-to-mesenchymal transition (EMT), which in prostate cancer (PCa) correlates with castration resistance, cancer stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f1a5e01386f4ae996ba7fdab9b1d97
http://hdl.handle.net/11383/2061806

Zobrazit plný text záznamu

The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression

Autor: Carlo V. Catapano, Paolo Kunderfranco, Giovanna Chiorino, Manuela Sarti, E Roggero, Ian Marc Bonapace, Ilaria Castiglioni, Pierre Oudet, Federica Babbio, Giuseppina M. Carbone, Laura Curti, Sandra Pinton, Maurizia Mello-Grand, Christian Pistore, Roland Seiler, Laurent Brino, G N Thalman

Publikováno v: Oncogene. 31:4878-4887

Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de7429d8d8febd2d6b4997207537e18
https://doi.org/10.1038/onc.2011.641

Zobrazit plný text záznamu

Np95 Is Implicated in Pericentromeric Heterochromatin Replication and in Major Satellite Silencing

Autor: Diego Negri, Ian Marc Bonapace, Roberto Papait, Daniela Pecoraro, Lisa Cantarini, Christian Pistore

Publikováno v: Web of Science

Heterochromatin plays an important role in transcriptional repression, for the correct segregation of chromosomes and in the maintenance of genome stability. Pericentric heterochromatin (PH) replication and formation have been proposed to occur in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6960469a1154d5ad6415351426678861
https://doi.org/10.1091/mbc.e06-09-0874

Zobrazit plný text záznamu

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression

Autor: Alessandra Fucci, Lina Sabatino, Lucia Altucci, Vittorio Colantuoni, Vincenzo Carafa, Massimo Pancione, Angela Nebbioso, Michele Ceccarelli, Carmelo Laudanna, Carolina Votino, Christian Pistore, Federica Babbio, Ian Marc Bonapace

Publikováno v: Oncogene (Basingstoke) 31(49) (2012): 5061–5072. doi:10.1038/onc.2012.3.
info:cnr-pdr/source/autori:Sabatino L, Fucci A, Pancione M, Carafa V, Nebbioso A, Pistore C, Babbio F, Votino C, Laudanna C, Ceccarelli M, Altucci L, Bonapace IM, Colantuoni V./titolo:UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression./doi:10.1038%2Fonc.2012.3./rivista:Oncogene (Basingstoke)/anno:2012/pagina_da:5061/pagina_a:5072/intervallo_pagine:5061–5072/volume:31(49)

""Peroxisome proliferator-activated receptor gamma (PPARG) inactivation has been identified as an important step in colorectal cancer (CRC) progression, although the events involved have been partially clarified. UHRF1 is emerging as a cofactor that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51a2d00881bbc3b9997d17a9a40470d

Zobrazit plný text záznamu

The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin

Autor: Daniela Pecoraro, Laurent Brino, Fabio Spada, Fraser McBlane, Pierre Oudet, Anne Laure Morand, Roberto Papait, Ian Marc Bonapace, Sara Cogliati, Anne Marie Dechampesme, Ursula Grazini, Heinrich Leonhardt, Christian Pistore, Federica Babbio

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2008, 19 (8), pp.3554-63. ⟨10.1091/mbc.E07-10-1059⟩
Molecular Biology of the Cell, 2008, 19 (8), pp.3554-63. ⟨10.1091/mbc.E07-10-1059⟩

Monitoring Editor: Yixian Zheng Heterochromatic chromosomal regions undergo large-scale reorganization and progressively aggregate, forming chromocenters. These are dynamic structures that rapidly adapt to various stimuli that influence gene expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ab8d2fc74b3df9305d6d84c90a9232
https://europepmc.org/articles/PMC2488286/

Zobrazit plný text záznamu

Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells

Autor: Ilaria Castiglioni, Elena Monti, Elena Magnani, Federica Babbio, Ian Marc Bonapace, Gianfranco Badaracco, Marzia B. Gariboldi, Chiara Cassina, Christian Pistore

Publikováno v: BMC Cell Biology
BMC Cell Biology, Vol 13, Iss 1, p 19 (2012)

Background MeCP2 (CpG-binding protein 2) is a nuclear multifunctional protein involved in several cellular processes, like large-scale chromatin reorganization and architecture, and transcriptional regulation. In recent years, a non-neuronal role for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33693c9d079a2274d984a908c38a1eb
http://europepmc.org/articles/PMC3477090

Zobrazit plný text záznamu

Abstract 196: UHRF1 is upregulated in prostate cancer and induces epigenetic silencing of tumor suppressor genes

Autor: Federica Babbio, Christian Pistore, Marco Magistri, Paolo Kunderfranco, Carlo V. Catapano, Ian Marc Bonapace, Giuseppina M. Carbone, Laura Curti, Giovanna Chiorino

Publikováno v: Cancer Research. 70:196-196

Cancer of the prostate is the most common cancer and a leading cause of cancer death in Europe and North America. At the present there is a need to understand the mechanisms involved in the pathogenesis of this disease and discover alternative therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ec2c2911129c21cd6ae16b59ecc72b
https://doi.org/10.1158/1538-7445.am10-196

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání