Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Christian Pinali"'
Autor:
Brian X. Wang, Christopher Kane, Laura Nicastro, Oisín King, Worrapong Kit-Anan, Barrett Downing, Graziano Deidda, Liam S. Couch, Christian Pinali, Anna Mitraki, Kenneth T. MacLeod, Cesare M. Terracciano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10940 (2022)
Engagement of the sarcoplasmic reticulum (SR) Ca2+ stores for excitation–contraction (EC)-coupling is a fundamental feature of cardiac muscle cells. Extracellular matrix (ECM) proteins that form the extracellular scaffolding supporting cardiac cont
Externí odkaz:
https://doaj.org/article/a0c335a772f34dd3b77998664e203c38
Autor:
Matthew Baxter, Maria Voronkov, Toryn Poolman, Gina Galli, Christian Pinali, Laurence Goosey, Abigail Knight, Karolina Krakowiak, Robert Maidstone, Mudassar Iqbal, Min Zi, Sukhpal Prehar, Elizabeth J Cartwright, Julie Gibbs, Laura C Matthews, Antony D Adamson, Neil E Humphreys, Pedro Rebelo-Guiomar, Michal Minczuk, David A Bechtold, Andrew Loudon, David Ray
Publikováno v:
eLife, Vol 9 (2020)
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly regulated in response to inter
Externí odkaz:
https://doaj.org/article/c80495bec8114315bceead7ae22ca77e
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 8, p e1005714 (2017)
Intracellular calcium cycling is a vital component of cardiac excitation-contraction coupling. The key structures responsible for controlling calcium dynamics are the cell membrane (comprising the surface sarcolemma and transverse-tubules), the intra
Externí odkaz:
https://doaj.org/article/63f6e3d956cf40498156d469bbba5bba
Autor:
Christian Pinali, Nadim Malik, J. Bernard Davenport, Laurence J. Allan, Lucy Murfitt, Mohammad M. Iqbal, Mark R. Boyett, Elizabeth J. Wright, Rachel Walker, Yu Zhang, Halina Dobryznski, Cathy M. Holt, Ashraf Kitmitto
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundHeart failure is a common secondary complication following a myocardial infarction (MI), characterized by impaired cardiac contraction and t‐tubule (t‐t) loss. However, post‐MI nano‐scale morphological changes to the remaining t‐t
Externí odkaz:
https://doaj.org/article/78d74663cfa54af9bef238c7a61d8829
Autor:
Christina S Kamma-Lorger, Christian Pinali, Juan Carlos Martínez, Jon Harris, Robert D Young, Cecilie Bredrup, Eva Crosas, Marc Malfois, Eyvind Rødahl, Keith M Meek, Carlo Knupp
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147948 (2016)
The role of Decorin in organising the extracellular matrix was examined in normal human corneas and in corneas from patients with Congenital Stromal Corneal Dystrophy (CSCD). In CSCD, corneal clouding occurs due to a truncating mutation (c.967delT) i
Externí odkaz:
https://doaj.org/article/2dc78dd99a2947dda0328e8160d7b867
Publikováno v:
Biology, Vol 5, Iss 4, p 41 (2016)
Defining the structural changes involved in the myosin cross-bridge cycle on actin in active muscle by X-ray diffraction will involve recording of the whole two dimensional (2D) X-ray diffraction pattern from active muscle in a time-resolved manner.
Externí odkaz:
https://doaj.org/article/678d9da3bb7d4fc4bded2bd2360ec759
Autor:
Tharushi Perera, Charlene Pius, Barbara Niort, Emma J. Radcliffe, Katharine M. Dibb, Andrew W. Trafford, Christian Pinali
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 377
The highly organized transverse tubule (t-tubule) network facilitates cardiac excitation–contraction coupling and synchronous cardiac myocyte contraction. In cardiac failure secondary to myocardial infarction (MI), changes in the structure and orga
Autor:
Charlotte E.R. Smith, Christian Pinali, David A. Eisner, Andrew W. Trafford, Katharine M. Dibb
Publikováno v:
Smith, C E R, Pinali, C, Eisner, D, Trafford, A & Dibb, K 2022, ' Enhanced calcium release at specialised surface sites compensates for reduced t-tubule density in neonatal sheep atrial myocytes ', Journal of molecular and cellular cardiology . https://doi.org/10.1016/j.yjmcc.2022.08.360
Cardiac myocytes rely on transverse (t)-tubules to facilitate a rapid rise in calcium throughout the cell. However, despite their importance in triggering synchronous Ca2+ release, t-tubules are highly labile structures. They develop postnatally, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c8045946ab38a0faf98e1324fe3042
https://research.manchester.ac.uk/en/publications/c6f2ded7-77f9-4c7b-862b-dc389469c836
https://research.manchester.ac.uk/en/publications/c6f2ded7-77f9-4c7b-862b-dc389469c836
Autor:
David A. Eisner, Christian Pinali, Emma J. Radcliffe, Charles M. Pearman, Katharine M. Dibb, Charlotte E.R. Smith, Andrew W. Trafford, Amy E. Watkins, Margaux A. Horn, Jessica D. Clarke, Jessica L. Caldwell, Elizabeth F. Bode, Mark Eisner, Aiste Adomaviciene, Callum J. Quinn
Transverse (t)-tubules drive the rapid and synchronous Ca2+ rise in cardiac myocytes. The virtual complete loss of atrial t-tubules in heart failure (HF) decreases Ca2+ release. It is unknown if or how atrial t-tubules can be restored and if restored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02108dfbd18274c30eadfa093f6d108
https://doi.org/10.1101/2021.10.28.466162
https://doi.org/10.1101/2021.10.28.466162
BS9 Regional alterations to the transverse-tubule network in an ovine model of myocardial infarction
Autor:
Andrew W. Trafford, Emma J. Radcliffe, Charlene Pius, Barbara Niort, Christian Pinali, Tharushi Perera
Publikováno v:
Basic science.
The highly organised transverse tubule (t-tubule) network consisting of invaginations of the cell sarcolemma facilitates synchronous cardiac myocyte contraction. This study aimed to investigate post-myocardial infarction (MI) t-tubule remodelling in