Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Christian P R Hackenberger"'
Autor:
Paul Majkut, Iris Claußnitzer, Helmut Merk, Christian Freund, Christian P R Hackenberger, Michael Gerrits
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82352 (2013)
The characterization of phosphotyrosine mediated protein-protein interactions is vital for the interpretation of downstream pathways of transmembrane signaling processes. Currently however, there is a gap between the initial identification and charac
Externí odkaz:
https://doaj.org/article/1f37255e948f4634ba364d2df5f58478
Autor:
Vanessa Hagenhaus, Jacob L. Gorenflos López, Rebecca Rosenstengel, Carolin Neu, Christian P. R. Hackenberger, Arif Celik, Klara Weinert, Mai-Binh Nguyen, Kaya Bork, Rüdiger Horstkorte, Astrid Gesper
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 422 (2023)
Mutations in the gene coding for the bi-functional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of the sialic acid biosynthesis, are responsible for autosomal-recessive GNE myopathy (GNEM). GNEM is an adult-ons
Externí odkaz:
https://doaj.org/article/702e7a0e6dba49f4aba8f031da5c0173
Autor:
François-Xavier Cantrelle, Anne Loyens, Xavier Trivelli, Oliver Reimann, Clément Despres, Neha S. Gandhi, Christian P. R. Hackenberger, Isabelle Landrieu, Caroline Smet-Nocca
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer’s disease (AD) brains. In recent years, other posttrans
Externí odkaz:
https://doaj.org/article/8d012c8e67d54abab12653fa56319bc6
Autor:
Raphael Brandt, Sara Timm, Jacob L. Gorenflos López, Jubilant Kwame Abledu, Wolfgang M. Kuebler, Christian P. R. Hackenberger, Matthias Ochs, Elena Lopez-Rodriguez
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
The glycocalyx—a plethora of sugars forming a dense layer that covers the cell membrane—is commonly found on the epithelial surface of lumen forming tissue. New glycocalyx specific properties have been defined for various organs in the last decad
Externí odkaz:
https://doaj.org/article/c18aa06fa0b4462ea03aeb962ea09827
Autor:
Philipp Ochtrop, Jahaziel Jahzerah, Paul Machui, Isabelle Mai, Dominik Schumacher, Jonas Helma, Marc-André Kasper, Christian P. R. Hackenberger
Publikováno v:
Chemical Science. 14:2259-2266
Compact phosphonamidate building blocks enable the simple construction of homogeneous DAR8 ADCs from native antibodies and hydrophobic payloads. The resulting ADCs exhibit excellent in vivo stability, clearance rates and antitumor activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c030d1f8e8859610dcb28140584d7e95
https://doi.org/10.1039/d2sc05678j
https://doi.org/10.1039/d2sc05678j
Autor:
Jacob L. Gorenflos López, Peter Schmieder, Kristin Kemnitz-Hassanin, Hatice Ceyda Asikoglu, Arif Celik, Christian E. Stieger, Dorothea Fiedler, Stephan Hinderlich, Christian P. R. Hackenberger
Publikováno v:
Chemical Science. 14:3482-3492
From chemical shifts to conversion velocity: real-time NMR spectroscopy using a combination of 1D and 2D experiments can monitor individual enzymatic steps in the sialic acid biosynthesis pathway in rat liver cytosolic extract.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d424d04c5a4a7e5c832a81b7d881fe8
https://doi.org/10.1039/d2sc06986e
https://doi.org/10.1039/d2sc06986e
Autor:
Jordi Bertran-Vicente, Martin Penkert, Olaia Nieto-Garcia, Jean-Marc Jeckelmann, Peter Schmieder, Eberhard Krause, Christian P. R. Hackenberger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Protein phosphorylation mediates signalling and other important cellular processes, but the specific effect of cysteine phosphorylation is unclear. Here, the authors present a chemical strategy to selectively phosphorylate cysteine residues and a mas
Externí odkaz:
https://doaj.org/article/1040c880158d473390673af6b138aded
Autor:
Don S. Munasinghe, Marc‐André Kasper, Radomir Jasiński, Karolina Kula, Marcin Palusiak, Małgorzata Celeda, Grzegorz Mlostoń, Christian P. R. Hackenberger
Publikováno v:
Chemistry – A European Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07da034cbb56b7d3580cd8f13ce68e2e
https://doi.org/10.1002/chem.202300806
https://doi.org/10.1002/chem.202300806
Publikováno v:
CHIMIA, Vol 72, Iss 11 (2018)
Proteins and peptides are gaining increasing interest as tools and targets in fundamental research and drug discovery. Growing research applications have prompted the need for methodologies that produce homogenous peptide and protein material. The de
Externí odkaz:
https://doaj.org/article/89ad16218bac43da9db774939c4428cd
Autor:
Michaela Mühlberg, Michael G. Hoesl, Christian Kuehne, Jens Dernedde, Nediljko Budisa, Christian P. R. Hackenberger
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 784-791 (2015)
To add new tools to the repertoire of protein-based multivalent scaffold design, we have developed a novel dual-labeling strategy for proteins that combines residue-specific incorporation of unnatural amino acids with chemical oxidative aldehyde form
Externí odkaz:
https://doaj.org/article/154a8f6343a44666b708e867faa90be7