Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia

Autor: Guoyue Xu, Rebekah van Bruggen, Christian O. Gualtieri, Neda Moradin, Adrien Fois, Diane Vallerand, Mariana De Sa Tavares Russo, Angelia Bassenden, Wenyun Lu, Mifong Tam, Sylvie Lesage, Hélène Girouard, Daina Zofija Avizonis, Geneviève Deblois, Josef T. Prchal, Mary Stevenson, Albert Berghuis, Tom Muir, Joshua Rabinowitz, Silvia M. Vidal, Nassima Fodil, Philippe Gros

Publikováno v: Cell Reports, Vol 32, Iss 12, Pp 108170- (2020)

Summary: The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, bisphosphoglycerate muta

Externí odkaz: https://doaj.org/article/262bb3d083ec462590385e23ff946934

Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population

Autor: Christian O. Gualtieri, B S Sirima, Jean-François Trape, Alexandra Iliescu, Pratap Singhasivanon, Rebekah van Bruggen, Philippe Gros, David Modiano, Anavaj Sakuntabhai, Punchalee Mungkalasut, Chalisa Louicharoen Cheepsunthorn, Jean-François Bureau, Mark Lathrop

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144555 (2015)
PLoS ONE
PLoS ONE, 2015, 10 (12), pp.e0144555. ⟨10.1371/journal.pone.0144555⟩
PLoS ONE, Public Library of Science, 2015, 10 (12), pp.e0144555. ⟨10.1371/journal.pone.0144555⟩

International audience; Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. We have shown that Pklr deficiency in mice reduces the severity (reduced parasitemia, increased survival) of blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296cb9a8412d1350edaf5c54c369bc7c
http://europepmc.org/articles/PMC4677815?pdf=render