Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Christian N. Cunningham"'
Autor:
Dawei Sun, Kelly M. Storek, Dimitry Tegunov, Ying Yang, Christopher P. Arthur, Matthew Johnson, John G. Quinn, Weijing Liu, Guanghui Han, Hany S. Girgis, Mary Kate Alexander, Austin K. Murchison, Stephanie Shriver, Christine Tam, Hiroshi Ijiri, Hiroko Inaba, Tatsuya Sano, Hayato Yanagida, Junichi Nishikawa, Christopher E. Heise, Wayne J. Fairbrother, Man-Wah Tan, Nicholas Skelton, Wendy Sandoval, Benjamin D. Sellers, Claudio Ciferri, Peter A. Smith, Patrick C. Reid, Christian N. Cunningham, Steven T. Rutherford, Jian Payandeh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract BamA is the central component of the essential β-barrel assembly machine (BAM), a conserved multi-subunit complex that dynamically inserts and folds β-barrel proteins into the outer membrane of Gram-negative bacteria. Despite recent advanc
Externí odkaz:
https://doaj.org/article/bf48c6d78a39468c81c644c4c61faa56
Autor:
Colin A. Grambow, Hayley Weir, Christian N. Cunningham, Tommaso Biancalani, Kangway V. Chuang
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Computational and machine learning approaches to model the conformational landscape of macrocyclic peptides have the potential to enable rational design and optimization. However, accurate, fast, and scalable methods for modeling macrocycle
Externí odkaz:
https://doaj.org/article/ab3300a15e9b4d60996b80fdf5758f0c
Publikováno v:
ACS Central Science, Vol 9, Iss 8, Pp 1603-1610 (2023)
Externí odkaz:
https://doaj.org/article/3c8ccd3584724c61af88e6c23b412553
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Technologies for discovering peptides as potential therapeutics have rapidly advanced in recent years with significant interest from both academic and pharmaceutical labs. These advancements in turn drive the need for new computational tools to desig
Externí odkaz:
https://doaj.org/article/85b383fade1b46b99f3aae56839b4388
Autor:
Juan Hu, Alix I Chan, Emel Adaligil, Ivy Kekessie, Mifune Takahashi, Aimin Song, Christian N. Cunningham, Brian M. Paegel
Publikováno v:
Journal of Medicinal Chemistry. 66:6288-6296
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25660f2143f10e27703c822d080f42a3
https://doi.org/10.1021/acs.jmedchem.3c00138
https://doi.org/10.1021/acs.jmedchem.3c00138
Autor:
Man-Ling Lee, Sherif Farag, Joselyn S. Del Cid, Charlene Bashore, Kenneth K. Hallenbeck, Alberto Gobbi, Christian N. Cunningham
Publikováno v:
ACS Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da7f5f2dfcc29682373f5c437c140de
https://doi.org/10.1021/acschembio.3c00159
https://doi.org/10.1021/acschembio.3c00159
Autor:
Yukuang Guo, Shaofei Ji, Wei Wang, Susan Wong, Chun-Wan Yen, Chloe Hu, Dennis H. Leung, Emile Plise, Shu Zhang, Chenghong Zhang, Uchenna A. Anene, Donglu Zhang, Christian N. Cunningham, S. Cyrus Khojasteh, Dian Su
Publikováno v:
Analytical Chemistry. 94:2032-2041
Macrocyclic peptides (MCPs) are an emerging class of promising drug modalities that can be used to interrogate hard-to-drug ("undruggable") targets. However, their poor intestinal stability is one of the major liabilities or obstacles for oral drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cbd97bca40f90f04343294eb79b0cb
https://doi.org/10.1021/acs.analchem.1c04008
https://doi.org/10.1021/acs.analchem.1c04008
Autor:
Alix I Chan, Manali S. Sawant, Daniel J. Burdick, Jeffrey Tom, Aimin Song, Christian N. Cunningham
Publikováno v:
ACS chemical biology.
Advances in genetic code reprogramming have allowed the site-specific incorporation of noncanonical functionalities into polypeptides and proteins, providing access to wide swaths of chemical space via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cf6e4c3b29b6e1dc433975d6e06a79
https://pubmed.ncbi.nlm.nih.gov/36607609
https://pubmed.ncbi.nlm.nih.gov/36607609
Publikováno v:
ACS Chemical Biology. 16:1325-1331
Herein, we report the ribosomal elongation of linear γ4- and β-hydroxy-γ4-amino acids (statines) to expand the nonproteinogenic amino acid repertoire of natural product-like combinatorial peptide libraries. First, we demonstrated the successful ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8c5fae979a57d9733f4893f651d75a
https://doi.org/10.1021/acschembio.1c00292
https://doi.org/10.1021/acschembio.1c00292
Publikováno v:
ACS Symposium Series ISBN: 9780841297616
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fff49015aa2a338e8c5ce820f74261e
https://doi.org/10.1021/bk-2022-1417.ch002
https://doi.org/10.1021/bk-2022-1417.ch002
