Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Christian N Parker"'
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Oliver Simic, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a v
Externí odkaz:
https://doaj.org/article/d64305878b7f4abe9dd92a3040e7b4f4
Autor:
Heinz Ruffner, Joëlle Sprunger, Olga Charlat, Juliet Leighton-Davies, Bianka Grosshans, Adrian Salathe, Svenja Zietzling, Valérie Beck, Maxime Therier, Andrea Isken, Yang Xie, Yue Zhang, Huaixiang Hao, Xiaoying Shi, Dong Liu, Qinhui Song, Ieuan Clay, Gabriele Hintzen, Jan Tchorz, Laure C Bouchez, Gregory Michaud, Peter Finan, Vic E Myer, Tewis Bouwmeester, Jeff Porter, Marc Hild, Fred Bassilana, Christian N Parker, Feng Cong
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40976 (2012)
The Wnt/β-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β-catenin signaling, however, the molecular mechanism of RSPO action is not
Externí odkaz:
https://doaj.org/article/bd2794bcdd5c40a0903a9b2a0d7c9a22
Autor:
Lukas-Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philipp Couttet, Frederic Sigoillot, Jana Ziegelmüller, Anne-Christine Uldry, Wojciech Teodorowicz, Niko Schmiedeberg, Oliver Mühlemann, Jürgen Reinhardt
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113159- (2023)
Externí odkaz:
https://doaj.org/article/a17f69f34eb64c599e2fdcd86f226d38
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2e8d59f2b3487af480f725db360e69
https://doi.org/10.1101/2023.02.08.527642
https://doi.org/10.1101/2023.02.08.527642
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Svenja Wöhrle, Larissa Fischer, Anna Kostina, Stephan Flemming, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian N. Parker, Andreas Boettcher, Christopher J. Farady, Rebecca Kesselring, Christopher Berlin, Rolf Backofen, Marta Rodriguez-Franco, Clemens Kreutz, Marco Prinz, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Publikováno v:
Science Signaling. 16
Inflammasomes are intracellular protein complexes that promote an inflammatory host defense in response to pathogens and damaged or neoplastic tissues and are implicated in inflammatory disorders and therapeutic-induced toxicity. We investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4bf91e4a3197215eb77ef358cd0bbb
https://doi.org/10.1126/scisignal.abh1083
https://doi.org/10.1126/scisignal.abh1083
Autor:
Katarina Petrovic, Martin Pfeifer, Günther Scheel, Dominic Hoepfner, Sven Schuierer, Stephen B. Helliwell, Christian N. Parker, John A. Tallarico, N. Rao Movva
Publikováno v:
Microbiological Research. 199:10-18
The budding yeast S. cerevisiae is widely used as a eukaryotic model organism to elucidate the mechanism of action of low molecular weight compounds. This report describes the development of two high throughput screening methods based on cell viabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f1b30fcb1b7c2f87c1fda012965ade
https://doi.org/10.1016/j.micres.2017.02.004
https://doi.org/10.1016/j.micres.2017.02.004
Autor:
Imtiaz Hossain, Jeremy L. Jenkins, Yann Abraham, Nicholas Holway, Xian Zhang, John A. Tallarico, Christine D. Wilson, Fred Harbinski, Christian N. Parker, Ioannis Moutsatsos, Claudia Agarinis, Luc Dobler
Publikováno v:
Slas Discovery
High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585bbe1eada878b56467b5b6e8adb160
http://europepmc.org/articles/PMC5322829
http://europepmc.org/articles/PMC5322829
Publikováno v:
Expert Opinion on Drug Discovery. 11:415-423
High throughput screening has become a basic technique with which to explore biological systems. Advances in technology, including increased screening capacity, as well as methods that generate multiparametric readouts, are driving the need for impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5417135f8a8ede13fdb0182ce1c6c7
https://doi.org/10.1517/17460441.2016.1154036
https://doi.org/10.1517/17460441.2016.1154036
Autor:
Teresa Alonso-Rasgado, Saeid Amini-Nik, Mohammed Ashrafi, Mohamed Baguneid, Jeremy Baskin, Ardeshir Bayat, Audrey Bélanger, François-Xavier Bernard, Manuel Berning, Katia Boniface, Charbel Bouez, Petra Boukamp, Nicholas Boulais, Jennifer Bourland, Virginie Buhé, Muriel Cario-André, Jean-Luc Carré, Mariana T. Cerqueira, Esteban Chacón-Solano, David Y.S. Chau, Vivien Chen, Lin Chen, Jérémy Chéret, José Cotovio, Stephen C. Davis, Marcela Del Río, Maria L. Dell'Anna, Marianne Deslauriers, Luisa A. DiPietro, Stefan Drakulich, Alexandra Duque-Fernandez, Julie Fradette, Jonathan A. Garlick, Behzad Gerami-Naini, George D. Glinos, Olivier Gouin, Sara Guerrero-Aspizua, Adam Hague, Kyle Hewitt, Victoria Hutter, Marc G. Jeschke, Olga Kashpur, Stewart B. Kirton, Ana Korosec, Dagmar Kulms, Manuela E.L. Lago, Fernando Larcher, Christelle Le Gall-Ianotto, Raphaële Le Garrec, Nicolas Lebonvallet, Raphaël Leschiera, Killian L'Hérondelle, Liang Liang, Beate M. Lichtenberger, Isabelle Lorthois, Maxim Maheux, Alexandra P. Marques, Lucía Martínez-Santamaría, Louis-Charles Masson, Stephanie H. Mathes, Friedegund Meier, Laurent Misery, Alexandre Morin, Nailia Mukhamedshina, Deborah G. Nguyen, Christian N. Parker, Irena Pastar, Elizabeth Pavez Loriè, Christian Pellevoisin, Ulysse Pereira, Rogério P. Pirraco, Roxane Pouliot, Rui L. Reis, Kelsey N. Retting, Geneviève Rioux, Bryan Roy, Mehdi Sakka, Andrew P. Sawaya, Megan Schrementi, Julien Seneschal, Yulia Shamis, Mélissa Simard, Philippe Simard, Avi Smith, Hans-Jürgen Stark, Olivera Stojadinovic, Alain Taieb, Matthieu Talagas, Marjana Tomic-Canic, Tongyu Cao Wikramanayake, Yusef Yousuf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0763722233a7ea62dfa65fce916c59c
https://doi.org/10.1016/b978-0-12-810545-0.09993-9
https://doi.org/10.1016/b978-0-12-810545-0.09993-9
Autor:
Christian N. Parker, Stephanie Mathes
In vitro skin models can be used in a number of ways, including assessment of the risk or efficacy of different treatments. As the pharmaceutical and cosmetic industries prepare for the increased use of such tissue equivalents, the question arises as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8e5f7253a0ab104a050bd808aa40057
https://doi.org/10.1016/b978-0-12-810545-0.00018-8
https://doi.org/10.1016/b978-0-12-810545-0.00018-8