Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Christian Much"'
Autor:
Christian Much, Erika L. Lasda, Isabela T. Pereira, Tenaya K. Vallery, Daniel Ramirez, Jordan P. Lewandowski, Robin D. Dowell, Michael J. Smallegan, John L. Rinn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Numerous studies have now demonstrated that lncRNAs can influence gene expression programs leading to cell and organismal phenotypes. Typically, lncRNA perturbations and concomitant changes in gene expression are measured on the timescale of
Externí odkaz:
https://doaj.org/article/ae6e1edc122642a7b2a728f5246773d8
Autor:
Alexandro Landshammer, Adriano Bolondi, Helene Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, Sebastian D Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L Rinn, Alexander Meissner
Publikováno v:
eLife, Vol 12 (2023)
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs rem
Externí odkaz:
https://doaj.org/article/3fce62d60c7b4d80ba98c9f07f7a3da0
Autor:
Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang, Emily Jacobs-Palmer, Nydia Chang, Christian Much, Kyle M. Turner, Christopher Kirby, Nimrod D. Rubinstein, Abigail F. Groff, Steve C. Liapis, Chiara Gerhardinger, Assaf Bester, Pier Paolo Pandolfi, John G. Clohessy, Hopi E. Hoekstra, Martin Sauvageau, John L. Rinn
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Abstract Background Several long noncoding RNAs (lncRNAs) have been shown to function as components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs in mammalian genomes has greatly expanded, studyin
Externí odkaz:
https://doaj.org/article/c0afc736c1d14340901a97d94751f3ae
Autor:
Azzurra Codino, Tomasz Turowski, Louie N. van de Lagemaat, Ivayla Ivanova, Andrea Tavosanis, Christian Much, Tania Auchynnikava, Lina Vasiliauskaitė, Marcos Morgan, Juri Rappsilber, Robin C. Allshire, Kamil R. Kranc, David Tollervey, Dónal O'Carroll
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102762- (2021)
Summary: Spermatogonial stem cells (SSCs) sustain spermatogenesis and fertility throughout adult male life. The conserved RNA-binding protein NANOS2 is essential for the maintenance of SSCs, but its targets and mechanisms of function are not fully un
Externí odkaz:
https://doaj.org/article/c901871256cd489d8e9d27e417a6e14f
Autor:
Christian Much, Tania Auchynnikava, Dinko Pavlinic, Andreas Buness, Juri Rappsilber, Vladimir Benes, Robin Allshire, Dónal O'Carroll
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006095 (2016)
Dicer is a large multi-domain protein responsible for the ultimate step of microRNA and short-interfering RNA biogenesis. In human and mouse cell lines, Dicer has been shown to be important in the nuclear clearance of dsRNA as well as the establishme
Externí odkaz:
https://doaj.org/article/0c969ddb922b41318fc9f8d2531b1be4
Autor:
Stefano Comazzetto, Monica Di Giacomo, Kasper Dindler Rasmussen, Christian Much, Chiara Azzi, Emerald Perlas, Marcos Morgan, Dónal O'Carroll
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004597 (2014)
Male fertility requires the continuous production of high quality motile spermatozoa in abundance. Alterations in all three metrics cause oligoasthenoteratozoospermia, the leading cause of human sub/infertility. Post-mitotic spermatogenesis inclusive
Externí odkaz:
https://doaj.org/article/02729a72e6344132b5756a9e628216bf
Autor:
Christian Much, Michael J. Smallegan, Taeyoung Hwang, Skylar D. Hanson, Gabrijela Dumbović, John L. Rinn
Publikováno v:
RNA. 28:842-853
Long noncoding RNAs (lncRNAs) are rapidly evolving and thus typically poorly conserved in their sequences. How these sequence differences affect the characteristics and potential functions of lncRNAs with shared synteny remains unclear. Here we show
Autor:
Adriano Bolondi, Alexandro Landshammer, Helene Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, Sebastian D Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L Rinn, Alexander Meissner
Publikováno v:
eLife. 12
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs rem
Autor:
Adriano Bolondi, Alexandro Landshammer, Helene Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, Sebastian D Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L Rinn, Alexander Meissner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c030a4ffe976f35033d1e521d2fded54
https://doi.org/10.7554/elife.83077.sa2
https://doi.org/10.7554/elife.83077.sa2
Autor:
Alexandro Landshammer, Adriano Bolondi, Helene Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, Sebastian Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L. Rinn, Alexander Meissner
Publikováno v:
bioRxiv (Preprint Server)
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3271a29d6117417045244a45f19577f9
https://hdl.handle.net/21.11116/0000-000D-2D09-821.11116/0000-000D-2D0B-6
https://hdl.handle.net/21.11116/0000-000D-2D09-821.11116/0000-000D-2D0B-6