Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Christian Münch"'
Autor:
Benedikt Sauer, Nadja I. Lorenz, Iris Divé, Kevin Klann, Anna-Luisa Luger, Hans Urban, Jan-Hendrik Schröder, Joachim P. Steinbach, Christian Münch, Michael W. Ronellenfitsch
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Glioblastoma is an incurable brain tumor with a median survival below two years. Trials investigating targeted therapy with inhibitors of the kinase mTOR have produced ambiguous results. Especially combination of mTOR inhibition with standar
Externí odkaz:
https://doaj.org/article/9ab4a9c77f214ad88451e3c0fada1f73
Autor:
Benjamin Koch, Mahmoud Shehata, Christin Müller-Ruttloff, Shady A. Gouda, Nils Wetzstein, Sammy Patyna, Anica Scholz, Tobias Schmid, Ursula Dietrich, Christian Münch, John Ziebuhr, Helmut Geiger, Luis Martinez-Sobrido, Patrick C. Baer, Ahmed Mostafa, Stephan Pleschka
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionInfluenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during IAV infection, correlating with an increased mortal
Externí odkaz:
https://doaj.org/article/7ab24c6b07b54d538909b968359b9e77
Autor:
Raquel S. Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R. Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian J. P. Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, Daniela S. Krause
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a calcium gradient exists in t
Externí odkaz:
https://doaj.org/article/00699074cde14bba837f1807407edcf5
Autor:
Mahil Lambert, Jakob Gebel, Charlotte Trejtnar, Nicole Wesch, Süleyman Bozkurt, Martin Adrian-Allgood, Frank Löhr, Christian Münch, Volker Dötsch
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The p53 family member TAp63α plays an important role in maintaining the genetic integrity in oocytes. DNA damage, in particular DNA double strand breaks, lead to the transformation of the inhibited, only dimeric conformation into the active
Externí odkaz:
https://doaj.org/article/0bcc9b700f734ed4a581d69e6765fd1c
Autor:
Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113484- (2023)
Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent
Externí odkaz:
https://doaj.org/article/c6187d86919640fc8c826a912248ef14
Autor:
Iris Divé, Kevin Klann, Jonas B. Michaelis, Dennis Heinzen, Joachim P. Steinbach, Christian Münch, Michael W. Ronellenfitsch
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract Although malignant gliomas frequently show aberrant activation of the mammalian target of rapamycin (mTOR), mTOR inhibitors have performed poorly in clinical trials. Besides regulating cell growth and translation, mTOR controls the initiatio
Externí odkaz:
https://doaj.org/article/b2d083bc71b34d12a417806d3a467b6b
Autor:
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Süleyman Bozkurt, Nikolett Pahor, Carmina Fuss, Andreas Schirbel, Christina Schülein‐Völk, Alexander Buchberger, Marco A. Calzado Canale, Mathias Rosenfeldt, Ivan Dikic, Christian Münch, Markus E. Diefenbacher
Publikováno v:
Molecular Oncology, Vol 16, Iss 17, Pp 3082-3106 (2022)
Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK fam
Externí odkaz:
https://doaj.org/article/dce85c56cd0547f996b0cfb97c5fb3dc
Autor:
Jonas Benjamin Michaelis, Melinda Elaine Brunstein, Süleyman Bozkurt, Ludovico Alves, Martin Wegner, Manuel Kaulich, Christian Pohl, Christian Münch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mitophagy activation is mediated by mitochondrial depolarization. Here, the authors show that mitochondrial protein misfolding can activate mitophagy in a depolarization-independent manner mediated by a protein import reduction.
Externí odkaz:
https://doaj.org/article/28bd4ad93a744efda167cac0232e31a7
Autor:
Thomas Fischer, Oliver Hartmann, Michaela Reissland, Cristian Prieto-Garcia, Kevin Klann, Nikolett Pahor, Christina Schülein-Völk, Apoorva Baluapuri, Bülent Polat, Arya Abazari, Elena Gerhard-Hartmann, Hans-Georg Kopp, Frank Essmann, Mathias Rosenfeldt, Christian Münch, Michael Flentje, Markus E. Diefenbacher
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-22 (2022)
Abstract Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN. These tumors are supposed t
Externí odkaz:
https://doaj.org/article/6e2b77747e884b2d9b01fa05018ce46e
Publikováno v:
Bio-Protocol, Vol 12, Iss 24 (2022)
Mitochondria are cellular organelles essential for the function and survival of eukaryotic cells. Nearly all mitochondrial proteins are nuclear-encoded and require mitochondrial import upon their synthesis in the cytosol. Various approaches have been
Externí odkaz:
https://doaj.org/article/7f4c09d093be4471bf3a1d48e7c685ee