Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Christian Morath"'
Autor:
Louise Benning, Marie Bartenschlager, Heeyoung Kim, Christian Morath, Martin Zeier, Paul Schnitzler, Ralf Bartenschlager, Claudius Speer
Publikováno v:
Vaccines, Vol 12, Iss 7, p 738 (2024)
We recently showed that an adapted SARS-CoV-2 vaccine with wildtype and BA.4/BA.5 Omicron subtype epitopes induced a broad short-term immune response in hemodialysis patients. Antibodies with protective capacity were boosted significantly after a fol
Externí odkaz:
https://doaj.org/article/cd39910a4b1e49c190096ec53e541c09
Autor:
Marvin Reineke, Christian Morath, Claudius Speer, Markus Rudek, Christian Bundschuh, Julian A.F. Klein, Christoph F. Mahler, Florian Kälble, Christian Nusshag, Jörg Beimler, Martin Zeier, Ralf Bartenschlager, Paul Schnitzler, Louise Benning
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Following kidney transplantation, lifelong immunosuppressive therapy is essential to prevent graft rejection. On the downside, immunosuppression increases the risk of severe infections, a major cause of death among kidney transplant recipients (KTRs)
Externí odkaz:
https://doaj.org/article/b7c9265149374386b4ed873db12357b9
Autor:
Louise Benning, Christian Morath, Annette Fink, Markus Rudek, Claudius Speer, Florian Kälble, Christian Nusshag, Jörg Beimler, Constantin Schwab, Rüdiger Waldherr, Martin Zeier, Caner Süsal, Thuong Hien Tran
Publikováno v:
Transplant International, Vol 36 (2023)
Donor-derived cell-free DNA (dd-cfDNA) identifies allograft injury and discriminates active rejection from no rejection. In this prospective study, 106 kidney transplant recipients with 108 clinically indicated biopsies were enrolled at Heidelberg Un
Externí odkaz:
https://doaj.org/article/dd27de4fe00d46a19c12bf2a47c50f5f
Autor:
Matthias Schaier, Christian Morath, Lei Wang, Christian Kleist, Gerhard Opelz, Thuong Hien Tran, Sabine Scherer, Lien Pham, Naruemol Ekpoom, Caner Süsal, Gerald Ponath, Florian Kälble, Claudius Speer, Louise Benning, Christian Nusshag, Christoph F. Mahler, Luiza Pego da Silva, Claudia Sommerer, Angela Hückelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Rüdiger Waldherr, Paul Schnitzler, Uta Merle, Vedat Schwenger, Markus Krautter, Stephan Kemmner, Michael Fischereder, Manfred Stangl, Ingeborg A. Hauser, Anna-Isabelle Kälsch, Bernhard K. Krämer, Georg A. Böhmig, Carsten Müller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe administration of modified immune cells (MIC) before kidney transplantation led to specific immunosuppression against the allogeneic donor and a significant increase in regulatory B lymphocytes. We wondered how this approach affected th
Externí odkaz:
https://doaj.org/article/e8a3a583d0ee42d7b2d399e91afea0aa
Autor:
Christian Nusshag, Changli Wei, Eunsil Hahm, Salim S. Hayek, Jing Li, Beata Samelko, Christoph Rupp, Roman Szudarek, Claudius Speer, Florian Kälble, Matthias Schaier, Florian Uhle, Felix C.F. Schmitt, Mascha O. Fiedler, Ellen Krautkrämer, Yanxia Cao, Ricardo Rodriguez, Uta Merle, Jesper Eugen-Olsen, Martin Zeier, Markus A. Weigand, Christian Morath, Thorsten Brenner, Jochen Reiser
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Acute kidney injury (AKI) secondary to sepsis results in poor outcomes and conventional kidney function indicators lack diagnostic value. Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune–derived molecule implicated in in
Externí odkaz:
https://doaj.org/article/4d103726f05d4f84ae5ff657e01e292f
Autor:
Felix S. Seibert, Arturo Blazquez-Navarro, Bodo Hölzer, Adrian A. N. Doevelaar, Christian Nusshag, Uta Merle, Christian Morath, Panagiota Zgoura, Rita Dittmer, Sonja Schneppenheim, Jochen Wilhelm, Nina Babel, Ulrich Budde, Timm H. Westhoff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Ubiquitous microthromboses in the pulmonary vasculature play a crucial role in the pathogenesis of COVID-19 associated acute respiratory distress syndrome (ARDS). Excess of Willebrand factor (vWf) with intravascular multimer formation was id
Externí odkaz:
https://doaj.org/article/298a33855c324b0cbfa0cef5ee466dc9
Autor:
Eman H Ibrahim, Mostafa Aly, Christian Morath, Douaa M Sayed, Naruemol Ekpoom, Gerhard Opelz, Caner Süsal, Volker Daniel
Publikováno v:
Immunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1252-1271 (2021)
Abstract Objectives Regulatory B cells (Bregs) and T cells (Tregs) are thought to be involved in the regulation of graft acceptance in renal transplant recipients. However, mechanisms that affect Breg differentiation and interaction with Tregs are ra
Externí odkaz:
https://doaj.org/article/1ff313b744e84b828f6c6c0efd04c5d6
Autor:
Claudius Speer, Maximilian Töllner, Louise Benning, Marie Bartenschlager, Heeyoung Kim, Christian Nusshag, Florian Kälble, Marvin Reineke, Paula Reichel, Paul Schnitzler, Martin Zeier, Christian Morath, Wilhelm Schmitt, Raoul Bergner, Ralf Bartenschlager, Hanns-Martin Lorenz, Matthias Schaier
Publikováno v:
Viruses, Vol 15, Iss 8, p 1778 (2023)
Emerging omicron subtypes with immune escape lead to inadequate vaccine response with breakthrough infections in immunocompromised individuals such as Anti-neutrophil Cytoplasmic Antibody (ANCA)-associated vasculitis (AAV) patients. As AAV is conside
Externí odkaz:
https://doaj.org/article/64fdd2813be44dab986aa7b950fb5436
Autor:
Daniel Göth, Christoph F. Mahler, Florian Kälble, Claudius Speer, Louise Benning, Felix C. F. Schmitt, Maximilian Dietrich, Ellen Krautkrämer, Martin Zeier, Uta Merle, Christian Morath, Mascha O. Fiedler, Markus A. Weigand, Christian Nusshag
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 14, p 4669 (2023)
Extracorporeal liver-support therapies remain controversial in critically ill patients, as most studies have failed to show an improvement in outcomes. However, heterogeneous timing and inclusion criteria, an insufficient number of treatments, and th
Externí odkaz:
https://doaj.org/article/90c62abfe5ec47259368875b4795f327
Autor:
Lei Wang, Arianeb Mehrabi, Maria-Luisa Schubert, Anita Schmitt, Brigitte Neuber, Alexander Kunz, Angela Hückelhoven-Krauss, Carsten Müller-Tidow, Michael Schmitt, Christian Morath, Martin Zeier, Constantin Schwab, Anja Sander, Sabine Scherer, Claudius Speer, Christian Kleist, Claudia Sommerer, Florian Kälble, Christian Nusshag, Matthias Schaier, Louise Benning, Vedat Schwenger, Caner Süsal, Gerhard Opelz, T. Hien Tran, Stephan Kemmner, Michael Fischereder, Manfred Stangl, Ingeborg A. Hauser, Christian Bischofs, Sandra Sauer, Rüdiger Waldherr, Christopher Büsch, David Czock, Georg A Böhmig, Jochen Reiser, Axel Roers, Peter Terness, Volker Daniel
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Introduction Donor-derived modified immune cells (MIC) induced long-term specific immunosuppression against the allogeneic donor in preclinical models of transplantation. In a phase I clinical trial (TOL-1 Study), MIC treatment resulted in a cellular
Externí odkaz:
https://doaj.org/article/6362680b60bd43139a9d0cb0059a65b3