Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Christian Michels"'
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Akademický článek
Machine-learning vs. logistic regression for preoperative prediction of medical morbidity after fast-track hip and knee arthroplasty—a comparative study
Autor: Christian Michelsen, Christoffer C. Jørgensen, Mathias Heltberg, Mogens H. Jensen, Alessandra Lucchetti, Pelle B. Petersen, Troels Petersen, Henrik Kehlet, The Center for Fast-track Hip Knee Replacement Collaborative group, Frank Madsen, Torben B. Hansen, Kirill Gromov, Thomas Jakobsen, Claus Varnum, Soren Overgaard, Mikkel Rathsach, Lars Hansen
Publikováno v: BMC Anesthesiology, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Machine-learning models may improve prediction of length of stay (LOS) and morbidity after surgery. However, few studies include fast-track programs, and most rely on administrative coding with limited follow-up and information on
Externí odkaz: https://doaj.org/article/1864298286a649cea4f53a18bbca4ba8
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2
TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function
Autor: Konrad Sandhoff, Bernadette Breiden, Carien M. Niessen, Susanne Brodesser, Wilhelm Bloch, Uwe Galli, Catherin Niemann, Christian Günschmann, Peter Schettina, Christian Michels, Dagmar Fehrenschild
Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology; Vol 132
Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well characterized at the molecular level. Using Lef1 (lymphoid enhancer-binding factor 1) dominant-negative mutant mice, we demons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914beb7a874bf85c366804b9b71ac30d
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4
Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation
Autor: Carien M. Niessen, Linda Koch, F. Thomas Wunderlich, Jens C. Brüning, Hady Ibrahim, Ingo Haase, Christian Michels, Claudia Wickenhauser, Michael Tscharntke, Heike Stachelscheid, Annika Schmitz, Jeanie Scott
Publikováno v: The EMBO Journal. 27:2091-2101
The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that determine this potential have remained largely elusive. Here, we find that insulin and insulin-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fe6dc92dd7e70725ef3ce13fe84c19
https://doi.org/10.1038/emboj.2008.141
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5
Akademický článek
Spatial heterogeneity affects predictions from early-curve fitting of pandemic outbreaks: a case study using population data from Denmark
Autor: Mathias L. Heltberg, Christian Michelsen, Emil S. Martiny, Lasse Engbo Christensen, Mogens H. Jensen, Tariq Halasa, Troels C. Petersen
Publikováno v: Royal Society Open Science, Vol 9, Iss 9 (2022)
The modelling of pandemics has become a critical aspect in modern society. Even though artificial intelligence can help the forecast, the implementation of ordinary differential equations which estimate the time development in the number of susceptib
Externí odkaz: https://doaj.org/article/af86e2ae74004f25a5bb33ca8b870b48
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7
Cadherin-mediated regulation of tight junctions in stratifying epithelia
Autor: Carien M. Niessen, Saeed Yadranji Aghdam, Christian Michels
Publikováno v: Annals of the New York Academy of Sciences. 1165
In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play crucial functions in the regulation of the largest barrier of the organism, the stratifying
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7351aeb8142af8ff3d2b9961d1af33
https://pubmed.ncbi.nlm.nih.gov/19538302
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8
Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation
Autor: Paola Zigrino, Ingo Haase, Michael Leitges, André Le Bivic, Iris Helfrich, Annika Schmitz, Christian Michels, Carien M. Niessen
Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, 2007, 127, pp.782-791
Journal of Investigative Dermatology, Nature Publishing Group, 2007, 127, pp.782-791
The skin water barrier, essential for terrestrial life, is formed by a multilayered stratifying epithelium, which shows a polarized distribution of both differentiation and intercellular junction markers. Recently, several reports showed the crucial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf5c03cb520d4f29626f40081fa3f75
https://hal.science/hal-00159412
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