Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christian M. Wood"'
Autor:
Laith Alexander, Christian M. Wood, Philip L. R. Gaskin, Stephen J. Sawiak, Tim D. Fryer, Young T. Hong, Lauren McIver, Hannah F. Clarke, Angela C. Roberts
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Alexander et al. causally implicate over-activity in primate subgenual cingulate in affective and cardiovascular dysfunction relevant to anxiety and depression. Over-activation led to elevated activity in a stress-related network whilst decreasing ac
Externí odkaz:
https://doaj.org/article/c4882c5246f44a9f9ba8c63aa0cd943b
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100454- (2021)
Summary: Blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. This protocol describes how to train the common marmoset, Callithrix jacchus, on an appetitive Pavlovian conditioning paradigm to measure
Externí odkaz:
https://doaj.org/article/4c34f392d3784dfa8d273d7ec436b6c0
Autor:
Christian M. Wood, Laith Alexander, Johan Alsiö, Andrea M. Santangelo, Lauren McIver, Gemma J. Cockcroft, Angela C. Roberts
Publikováno v:
Science Translational Medicine. 15
Poor outcomes are common in individuals with anxiety and depression, and the brain circuits underlying symptoms and treatment responses remain elusive. To elucidate these neural circuits, experimental studies must specifically manipulate them, which
Autor:
Shaun K L Quah, Angela C. Roberts, Hannah F. Clarke, Gemma J Cockcroft, Andrea M. Santangelo, Nicole K. Horst, Kevin Mulvihill, Christian M Wood, Sufia S Rahman
Publikováno v:
Cerebral Cortex (New York, NY)
The midcingulate cortex (MCC) is associated with cognition and emotion regulation. Structural and correlational functional evidence suggests that rather than being homogenous, the MCC may have dissociable functions that can be mapped onto distinct su
Autor:
Hayley Raymond, Samita Kafle, Jacob S. Leiby, Timothy C. Nichols, Charles A. Assenmacher, Denise E. Sabatino, Haig H. Kazazian, C. Tyler Long, Giang N. Nguyen, Frederic D. Bushman, John K. Everett, Elizabeth P. Merricks, Christian M. Wood, Aoife M. Roche
Publikováno v:
Nature Biotechnology. 39:47-55
Nine dogs with hemophilia A were treated with adeno-associated viral (AAV) gene therapy and followed for up to 10 years. Administration of AAV8 or AAV9 vectors expressing canine factor VIII (AAV-cFVIII) corrected the FVIII deficiency to 1.9-11.3% of
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100454-(2021)
STAR Protocols
STAR Protocols
Summary Blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. This protocol describes how to train the common marmoset, Callithrix jacchus, on an appetitive Pavlovian conditioning paradigm to measure
Autor:
Lydia Oikonomidis, Christian M Wood, Angela C. Roberts, Lauren McIver, Kevin Mulvihill, Gemma J Cockcroft, Roohollah Massoudi, Zuzanna M Stawicka, Hannah F. Clarke, Nicole K. Horst, Shaun K L Quah
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 32(7)
Structural and functional abnormalities of the orbitofrontal cortex (OFC) have been implicated in affective disorders that manifest anxiety-related symptoms. However, research into the functions of primate OFC has predominantly focused on reward-orie
Autor:
Hannah F. Clarke, Laith Alexander, Angela C. Roberts, Stephen J. Sawiak, Lauren McIver, Philip L.R. Gaskin, Tim D. Fryer, Christian M Wood, Young T. Hong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25) has been implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eba638c8db9fb12ad300e77b8d339eb
Autor:
Christian M Wood, Nicole K. Horst, Andrea M. Santangelo, Laith Alexander, Philip L.R. Gaskin, Angela C. Roberts, Lauren McIver, Ken Koda, Roohollah Massoudi, Gemma J Cockcroft, Zuzanna M Stawicka
Publikováno v:
Proc Natl Acad Sci U S A
The ventromedial prefrontal cortex (vmPFC) is a key brain structure implicated in mood and anxiety disorders, based primarily on evidence from correlational neuroimaging studies. Composed of a number of brain regions with distinct architecture and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146646b79acc3adfd866b3d1c6512217
Publikováno v:
British Journal of Pharmacology. 174:3200-3210
BACKGROUND AND PURPOSE Predicting the risk of drug-induced adverse psychiatric effects is important but currently not possible in non-human species. We investigated whether the affective bias test (ABT) could provide a preclinical method with transla