Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christian M. Neuhaus"'
Publikováno v:
Molecules, Vol 25, Iss 19, p 4527 (2020)
Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycl
Externí odkaz:
https://doaj.org/article/c59843febd8f47639a976f043bf57a9d
Autor:
Michael Ol Steinmetz, Katja Bargsten, J. Fernando Díaz, Andrea E. Prota, May Marsh, José Manuel Andreu, Carmen Cuevas, Marc Liniger, Christian M. Neuhaus, Karl-Heinz Altmann
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
The recent success of antibody–drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubule-destabilizing agents. Here, we determined the high-resolution crystal structure of the complex between tubulin and maytans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e72a7297d206616c3a778e6af66759f
Publikováno v:
Angewandte Chemie. 125:5978-5983
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c79132536a6b3fe4ed8c609a440355e3
https://doi.org/10.1002/ange.201300576
https://doi.org/10.1002/ange.201300576
Publikováno v:
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Key steps in this total synthesis of the antimitotic natural product WF 1360F (3) include the formation of the macrocycle through ring closing alkyne metathesis and the subsequent conversion of the ensuing alkyne moiety into an E configured double bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd49633207696c4900e0df14963da86f
https://pubmed.ncbi.nlm.nih.gov/23610073
https://pubmed.ncbi.nlm.nih.gov/23610073