Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christian M. Loch"'
Autor:
Christine K. Schmidt, María J. Cabello-Lobato, Stephen P. Jackson, Matthew J. Cliff, Matthew Jenner, Qian Wu, Christian M. Loch
SUMOylation is critical for a plethora of cellular signalling pathways including the repair of DNA double-strand breaks (DSBs). If misrepaired, DSBs can lead to cancer, neurodegeneration, immunodeficiency and premature ageing. Based on systematic pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242da52e9e8d256f364e7ed1ae3f2093
https://doi.org/10.1101/2021.01.20.427433
https://doi.org/10.1101/2021.01.20.427433
Publikováno v:
The FASEB Journal. 25:3938-3948
We recently demonstrated that plasma membrane KCa3.1 is rapidly endocytosed and targeted for lysosomal degradation via a Rab7- and ESCRT-dependent pathway. Herein, we assess the role of ubiquitylation in this process. Using a biotin ligase acceptor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f248aed99cc123a578cf02cb759abe
https://doi.org/10.1096/fj.11-187005
https://doi.org/10.1096/fj.11-187005
Publikováno v:
Developmental Medicine & Child Neurology. 50:19-24
In this study we examined the relationship between diagnoses of isolated intrapartum fever or chorioamnionitis and the risk of encephalopathy in term newborns. We conducted a population-based, case-control study in Washington State using 1994 to 2002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e9169cc2c1e86f143de60dff9d602c
https://doi.org/10.1111/j.1469-8749.2007.02007.x
https://doi.org/10.1111/j.1469-8749.2007.02007.x
Autor:
Martin W. McIntosh, Cassandra L. Sather, Nicole Urban, Paul D. Lampe, Christian M. Loch, Arturo B. Ramirez, Yan Liu, Barbara Garvik, Nathalie Scholler, Jeffrey J. Delrow
Publikováno v:
Molecular Oncology. 1:313-320
Perhaps the greatest barrier to translation of serum biomarker discoveries is the inability to evaluate putative biomarkers in high throughput validation studies. Here we report on the development, production, and implementation of a high-density ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3311ce7ad17685fad226a64258fedf26
https://doi.org/10.1016/j.molonc.2007.08.004
https://doi.org/10.1016/j.molonc.2007.08.004
Publikováno v:
The FASEB Journal. 29
Ubiquitylation occurs through isopeptide linkage between the C-terminus of Ub and the e-amino group of a lysine residue on the target substrate. Ub itself has seven Lys residues (K6, K11, K27, K29,...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8213288e3f868e0fd97aad9e19bf9e1b
https://doi.org/10.1096/fasebj.29.1_supplement.883.14
https://doi.org/10.1096/fasebj.29.1_supplement.883.14
Publikováno v:
Traffic. 5:925-935
Autonomously replicating sequence-binding factor 1 (Abf1p) is a site-specific DNA binding protein in Saccharomyces cerevisiae that functions to regulate multiple nuclear events including DNA replication, transcriptional activation, and gene silencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10fa8e4ea8b062f029ce52c99187b68
https://doi.org/10.1111/j.1600-0854.2004.00233.x
https://doi.org/10.1111/j.1600-0854.2004.00233.x
Publikováno v:
Journal of Biological Chemistry. 279:34865-34872
Autonomously replicating sequence-binding factor-1 (Abf1p) is an essential sequence-specific transcription factor in Saccharomyces cerevisiae that participates in multiple nuclear events including DNA replication, transcription activation, and gene s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805116bd271490c54bf4dc88d88141f
https://doi.org/10.1074/jbc.m405156200
https://doi.org/10.1074/jbc.m405156200
Autor:
Paul W. Wright, Christopher M. Gough, Jonathan D. Monroe, Christian M. Loch, Joy E. Ferrante, Leeann E. Chandler
Publikováno v:
Plant Physiology. 119:385-398
Apoplastic α-glucosidases occur widely in plants but their function is unknown because appropriate substrates in the apoplast have not been identified. Arabidopsis contains at least three α-glucosidase genes; Aglu-1 and Aglu-3 are sequenced and Agl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74bd8fdd1985222b77180ec6ada5859
https://doi.org/10.1104/pp.119.2.385
https://doi.org/10.1104/pp.119.2.385
Publikováno v:
Cell biochemistry and biophysics. 60(1-2)
Although they are the primary determinants of substrate specificity, few E3-substrate pairs have been positively identified, and few E3’s profiled in a proteomic fashion. Praja1 is an E3 implicated in bone development and highly expressed in brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802c82d97d640ce3d4d7b1d390e3a30a
https://pubmed.ncbi.nlm.nih.gov/21461837
https://pubmed.ncbi.nlm.nih.gov/21461837
Publikováno v:
Molecular & Cellular Proteomics
Microarray-based proteomics expanded the information potential of DNA arrays to the level of protein translation and interaction, but so far, not much beyond. Although enzymatic activity from immobilized proteins has been reliably studied using surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d201b835cec5b18341f54da3b1eb4c8e