Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christian M. Cohrs"'
Autor:
Denise M. Drotar, Ana Karen Mojica-Avila, Drew T. Bloss, Christian M. Cohrs, Cameron T. Manson, Amanda L. Posgai, MacKenzie D. Williams, Maigan A. Brusko, Edward A. Phelps, Clive H. Wasserfall, Stephan Speier, Mark A. Atkinson
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114346- (2024)
Summary: Histopathological heterogeneity in the human pancreas is well documented; however, functional evidence at the tissue level is scarce. Herein, we investigate in situ glucose-stimulated islet and carbachol-stimulated acinar cell secretion acro
Externí odkaz:
https://doaj.org/article/fcfd2fb1042a446182c1c09a0ce0ffd8
Autor:
Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabe
Externí odkaz:
https://doaj.org/article/74611d8ea8d3455cb3cb7f860abbdb27
Publikováno v:
Molecular Metabolism, Vol 6, Iss 9, Pp 943-957 (2017)
Background: Plasma insulin levels are predominantly the product of the morphological mass of insulin producing beta cells in the pancreatic islets of Langerhans and the functional status of each of these beta cells. Thus, deficiency in either beta ce
Externí odkaz:
https://doaj.org/article/dfa0099d19ca43be9d38c0e18582a433
Autor:
Zahra Dantes, Maximilian Reichert, József Maléth, Thomas Engleitner, Thomas Seufferlein, MK Melzer, Christian M. Cohrs, J Merkle, Martin Wagner, Martin Müller, Tamara Madácsy, Joscha Griger, Cagatay Günes, Stefan Liebau, Markus Breunig, Matthias Meier, Thomas F. E. Barth, Sandra Wiedenmann, Patrick C. Hermann, Stephan Speier, Bernhard Kuster, Sandra Heller, Maximilian Schmid, Gaurav Jain, Pamela Gehron Robey, Johannes Krumm, Florian Kuhn, Lukas Perkhofer, Christian Bolenz, Oliver Wessely, Alexander Kleger, Bence Sipos, Árpád Varga, Ninel Azoitei, Roland Rad, Jana Krüger, Meike Hohwieler
Publikováno v:
Cell Stem Cell
Cell Stem Cell 28, 1105-1124.e19 (2021)
Cell Stem Cell 28, 1105-1124.e19 (2021)
Personalized invitro models for dysplasia and carcinogenesis in the pancreas have been constrained by insufficient differentiation of human pluripotent stem cells (hPSCs) into the exocrine pancreatic lineage. Here, we differentiate hPSCs into pancrea
Autor:
Stephen J. Enos, Mollie K. Huber, Joana Almaça, Jorge Santini, Ricardo L. Pastori, Mirza Muhammad Fahd Qadir, Alberto Pugliese, Christian M. Cohrs, Helmut Hiller, Stephan Speier, Maria Beery, Julia K. Panzer, Juan Domínguez-Bendala, Mark A. Atkinson, Alejandro Caicedo, Edward A. Phelps, Sirlene Cechin, John R. Weitz, Irina Kusmartseva, Denise M. Drotar
Publikováno v:
JCI insight 5:134525 (2020)
JCI Insight
JCI Insight
In type 1 diabetes (T1D), autoimmune destruction of pancreatic beta cells leads to insulin deficiency and loss of glycemic control. However, knowledge about human pancreas pathophysiology in T1D remains incomplete. To address this limitation, we esta
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2128
Noninvasive in vivo imaging techniques are attractive tools to longitudinally study various aspects of islet of Langerhans physiology and pathophysiology. Unfortunately, most imaging modalities currently applicable for clinical use do not allow the c
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2128
Studies on islet of Langerhans physiology are crucial to understand the role of the endocrine pancreas in diabetes pathogenesis and the development of new therapeutic approaches. However, so far most research addressing islet of Langerhans biology re
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603840
Studies on islet of Langerhans physiology are crucial to understand the role of the endocrine pancreas in diabetes pathogenesis and the development of new therapeutic approaches. However, so far most research addressing islet of Langerhans biology re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37855603bc9f4121be401e1a5ad4346c
https://doi.org/10.1007/978-1-0716-0385-7_20
https://doi.org/10.1007/978-1-0716-0385-7_20
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603840
Noninvasive in vivo imaging techniques are attractive tools to longitudinally study various aspects of islet of Langerhans physiology and pathophysiology. Unfortunately, most imaging modalities currently applicable for clinical use do not allow the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49384fa3cf51cb2cf8f122e557772093
https://doi.org/10.1007/978-1-0716-0385-7_11
https://doi.org/10.1007/978-1-0716-0385-7_11
Autor:
Wael A. Eter, Christian M. Cohrs, Desiree Bos, Maarten Brom, Lieke Claessens-Joosten, Gerwin Sandker, Cathelijne Frielink, Stephan Speier, Martin Gotthardt, Mijke Buitinga
Publikováno v:
Diabetes, 69, 11, pp. 2246-2252
Diabetes, 69, 2246-2252
Diabetes, 69(11), 2246-2252. American Diabetes Association
Diabetes 69, 2246-2252 (2020)
Diabetes
Diabetes, 69, 2246-2252
Diabetes, 69(11), 2246-2252. American Diabetes Association
Diabetes 69, 2246-2252 (2020)
Diabetes
Glucagon-like peptide 1 receptor (GLP-1R) imaging with radiolabeled exendin has proven to be a powerful tool to quantify β-cell mass (BCM) in vivo. As GLP-1R expression is thought to be influenced by glycemic control, we examined the effect of blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5123490c9da830c5eed5ba62a9e75229
https://hdl.handle.net/2066/226264
https://hdl.handle.net/2066/226264