Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning

Autor: Laith Alexander, Rana Banai-Tizkar, Christian M. Wood, Angela C. Roberts

Publikováno v: STAR Protocols, Vol 2, Iss 2, Pp 100454- (2021)

Summary: Blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. This protocol describes how to train the common marmoset, Callithrix jacchus, on an appetitive Pavlovian conditioning paradigm to measure

Externí odkaz: https://doaj.org/article/4c34f392d3784dfa8d273d7ec436b6c0

A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

Autor: Hayley Raymond, Samita Kafle, Jacob S. Leiby, Timothy C. Nichols, Charles A. Assenmacher, Denise E. Sabatino, Haig H. Kazazian, C. Tyler Long, Giang N. Nguyen, Frederic D. Bushman, John K. Everett, Elizabeth P. Merricks, Christian M. Wood, Aoife M. Roche

Publikováno v: Nature Biotechnology. 39:47-55

Nine dogs with hemophilia A were treated with adeno-associated viral (AAV) gene therapy and followed for up to 10 years. Administration of AAV8 or AAV9 vectors expressing canine factor VIII (AAV-cFVIII) corrected the FVIII deficiency to 1.9-11.3% of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3ee22b1fdc663cae7d19813bc5d7b3f
https://doi.org/10.1038/s41587-020-0741-7

Differential Effects of the Inactivation of Anterior and Posterior Orbitofrontal Cortex on Affective Responses to Proximal and Distal Threat, and Reward Anticipation in the Common Marmoset

Autor: Lydia Oikonomidis, Christian M Wood, Angela C. Roberts, Lauren McIver, Kevin Mulvihill, Gemma J Cockcroft, Roohollah Massoudi, Zuzanna M Stawicka, Hannah F. Clarke, Nicole K. Horst, Shaun K L Quah

Publikováno v: Cerebral cortex (New York, N.Y. : 1991). 32(7)

Structural and functional abnormalities of the orbitofrontal cortex (OFC) have been implicated in affective disorders that manifest anxiety-related symptoms. However, research into the functions of primate OFC has predominantly focused on reward-orie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699297b9736aef33de699bda2c04868f
https://pubmed.ncbi.nlm.nih.gov/34494095

Ventromedial prefrontal area 14 provides opposing regulation of threat and reward-elicited responses in the common marmoset

Autor: Christian M Wood, Nicole K. Horst, Andrea M. Santangelo, Laith Alexander, Philip L.R. Gaskin, Angela C. Roberts, Lauren McIver, Ken Koda, Roohollah Massoudi, Gemma J Cockcroft, Zuzanna M Stawicka

Publikováno v: Proc Natl Acad Sci U S A

The ventromedial prefrontal cortex (vmPFC) is a key brain structure implicated in mood and anxiety disorders, based primarily on evidence from correlational neuroimaging studies. Composed of a number of brain regions with distinct architecture and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146646b79acc3adfd866b3d1c6512217

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression

Autor: Christian M Wood, Emma S J Robinson, Elaine Shanks, Andrew McCarthy, David Lodge, Keith A. Wafford, Nicola Hewes

Publikováno v: Wood, C M, Wafford, K A, McCarthy, A P, Hewes, N, Shanks, E, Lodge, D & Robinson, E S J 2018, ' Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression ', Neuropharmacology, vol. 140, pp. 246-259 . https://doi.org/10.1016/j.neuropharm.2018.07.013

Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in a number of psychiatric disorders. They also control sleep-wake architecture and may offer novel therapeutic targets. However, the roles of the mGluR2 versus mGluR3 subty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e29726f12a34b086e2f9f1b82a29dd
https://hdl.handle.net/1983/41f2a04b-ca05-4241-91b1-d03e1465f030