Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christian M Udell"'
Autor:
Dariel Ashton-Beaucage, Caroline Lemieux, Christian M Udell, Malha Sahmi, Samuel Rochette, Marc Therrien
Publikováno v:
PLoS Biology, Vol 14, Iss 8, p e1002539 (2016)
RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic asp
Externí odkaz:
https://doaj.org/article/a7465c8bb83b454a9b21988e6f13f708
Autor:
Dariel Ashton-Beaucage, Christian M Udell, Patrick Gendron, Malha Sahmi, Martin Lefrançois, Caroline Baril, Anne-Sophie Guenier, Jean Duchaine, Daniel Lamarre, Sébastien Lemieux, Marc Therrien
Publikováno v:
PLoS Biology, Vol 12, Iss 3, p e1001809 (2014)
The small GTPase RAS is among the most prevalent oncogenes. The evolutionarily conserved RAF-MEK-MAPK module that lies downstream of RAS is one of the main conduits through which RAS transmits proliferative signals in normal and cancer cells. Genetic
Externí odkaz:
https://doaj.org/article/01a103f9c3ac49eb8d3c6471457dc715
Autor:
Samuel Rochette, Christian M. Udell, Dariel Ashton-Beaucage, Caroline Lemieux, Marc Therrien, Malha Sahmi
Publikováno v:
PLoS Biology
PLoS Biology, Vol 14, Iss 8, p e1002539 (2016)
PLoS Biology, Vol 14, Iss 8, p e1002539 (2016)
RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic asp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908a5a30748bf9c3fe0321136356bef1
https://pubmed.ncbi.nlm.nih.gov/27552662
https://pubmed.ncbi.nlm.nih.gov/27552662
Publikováno v:
Molecular Biology of the Cell. 10:1985-1995
Eukaryotic cells actively block entry into mitosis in the presence of DNA damage or incompletely replicated DNA. This response is mediated by signal transduction cascades called cell cycle checkpoints. We show here that the human checkpoint control p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae36662d0a66b8e7e249a0852b1f31e5
https://doi.org/10.1091/mbc.10.6.1985
https://doi.org/10.1091/mbc.10.6.1985
Publikováno v:
Cellular and molecular life sciences : CMLS. 68(4)
The RAF family of kinases are key components acting downstream of receptor tyrosine kinases and cells employ several distinct mechanisms to strictly control their activity. RAF transitions from an inactive state, where the N-terminal regulatory regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87a8be67a2130d71ed58177752d9d61
https://pubmed.ncbi.nlm.nih.gov/20820846
https://pubmed.ncbi.nlm.nih.gov/20820846
Autor:
Robert Karisch, Stephanie Everingham, Jimin Zheng, Andrew W.B. Craig, Zongchao Jia, Julie A. Smith, Christian M. Udell, Victor A. McPherson
Publikováno v:
Molecular and cellular biology. 29(2)
This study investigates the roles of Fer-CIP4 homology (FCH)-Bin/amphiphysin/Rvs (F-BAR) and SH2 domains of Fes protein tyrosine kinase in regulating its activation and signaling downstream of the high-affinity immunoglobulin G (IgE) receptor (Fcepsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed098b3737ee24df8a7e5818b7ab25b2
https://pubmed.ncbi.nlm.nih.gov/19001085
https://pubmed.ncbi.nlm.nih.gov/19001085
Autor:
Lionel A. Samayawardhena, Toshiaki Kawakami, Christian M. Udell, Andrew W.B. Craig, Yuko Kawakami
Publikováno v:
The Journal of biological chemistry. 281(30)
Mast cells express the high affinity IgE receptor FcepsilonRI, which upon aggregation by multivalent antigens elicits signals that cause rapid changes within the mast cell and in the surrounding tissue. We previously showed that FcepsilonRI aggregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e335a0ad647c0eea692ee1a5fcd96c21
https://pubmed.ncbi.nlm.nih.gov/16731527
https://pubmed.ncbi.nlm.nih.gov/16731527
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 4)
The MraZ family of proteins, also referred to as the UPF0040 family, are highly conserved in bacteria and are thought to play a role in cell-wall biosynthesis and cell division. The murein region A (mra) gene cluster encodes MraZ proteins along with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f995086b49f007ace1ceed102d0beeb6
https://pubmed.ncbi.nlm.nih.gov/16511046
https://pubmed.ncbi.nlm.nih.gov/16511046
Publikováno v:
Nucleic acids research. 26(17)
Eukaryotic cells arrest at the G2checkpoint in the presence of DNA damage or incompletely replicated DNA. This cell cycle checkpoint prevents the development and propagation of genomic instability. In the fission yeast, this process requires the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d442d0ba0fdefc50dd8cf8ac7c6767
https://pubmed.ncbi.nlm.nih.gov/9705507
https://pubmed.ncbi.nlm.nih.gov/9705507
Autor:
Pierre Thibault, Dariel Ashton-Beaucage, Hugo Lavoie, Pierre Chagnon, Caroline Baril, Patrick Gendron, Eric Bonneil, Olivier Caron-Lizotte, Martin Lefrançois, Marc Therrien, Christian M. Udell
Publikováno v:
Cell. (2):251-262
SummarySignaling pathways are controlled by a vast array of posttranslational mechanisms. By contrast, little is known regarding the mechanisms that regulate the expression of their core components. We conducted an RNAi screen in Drosophila for facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26385a158d65db3eeab6028f931a18f8