Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christian M, Harding"'
Autor:
Paeton L Wantuch, Cory J Knoot, Lloyd S Robinson, Evgeny Vinogradov, Nichollas E Scott, Christian M Harding, David A Rosen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011367 (2023)
Klebsiella pneumoniae presents as two circulating pathotypes: classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (hvKp). Classical isolates are considered urgent threats due to their antibiotic resistance profiles, while hvKp isolates have
Externí odkaz:
https://doaj.org/article/def5375bad9b4f5eadb7d9e69d0be7ab
Autor:
Christian M. Harding, Mohamed A. Nasr, Nichollas E. Scott, Guillaume Goyette-Desjardins, Harald Nothaft, Anne E. Mayer, Sthefany M. Chavez, Jeremy P. Huynh, Rachel L. Kinsella, Christine M. Szymanski, Christina L. Stallings, Mariela Segura, Mario F. Feldman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalen
Externí odkaz:
https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c
Autor:
Cory J Knoot, Paeton L Wantuch, Lloyd S Robinson, David A Rosen, Nichollas E Scott, Christian M Harding
Publikováno v:
Glycobiology. 33:57-74
Bacterial protein glycosylation is commonly mediated by oligosaccharyltransferases (OTases) that transfer oligosaccharides en bloc from preassembled lipid-linked precursors to acceptor proteins. Natively, O-linking OTases usually transfer a single re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794ba3b32517aa7a74cb02417d396ce3
https://doi.org/10.1093/glycob/cwac070
https://doi.org/10.1093/glycob/cwac070
Autor:
Javid Aceil, Amy V. Paschall, Cory J. Knoot, Lloyd S. Robinson, Nichollas E. Scott, Mario F. Feldman, Christian M. Harding, Fikri Y. Avci
Publikováno v:
Vaccine. 40:6107-6113
Capsular polysaccharides (CPSs), with which most pathogenic bacterial surfaces are decorated, have been used as the main components of glycoconjugate vaccines against bacterial diseases in clinical practice worldwide. Pneumococcal conjugate vaccines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4082a086dcaa05ba36b6770e1780f1
https://doi.org/10.1016/j.vaccine.2022.09.018
https://doi.org/10.1016/j.vaccine.2022.09.018
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005391 (2016)
Acinetobacter baumannii, A. nosocomialis, and A. pittii have recently emerged as opportunistic human pathogens capable of causing severe human disease; however, the molecular mechanisms employed by Acinetobacter to cause disease remain poorly underst
Externí odkaz:
https://doaj.org/article/c7e7ad7baf5b4caaa36425a1ecbf13a9
Autor:
Jeremy A, Duke, Amy V, Paschall, Lloyd S, Robinson, Cory J, Knoot, Evgeny, Vinogradov, Nichollas E, Scott, Mario F, Feldman, Fikri Y, Avci, Christian M, Harding
Publikováno v:
ACS Infect Dis
Group B Streptococcus (GBS) is a leading cause of neonatal infections and invasive diseases in nonpregnant adults worldwide. Developing a protective conjugate vaccine targeting the capsule of GBS has been pursued for more than 30 years; however, it h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db46616414ccf36c5b988537956e9747
https://pubmed.ncbi.nlm.nih.gov/34633812
https://pubmed.ncbi.nlm.nih.gov/34633812
Autor:
Christina L. Stallings, Christine M. Szymanski, Christian M. Harding, Anne E. Mayer, Mario F. Feldman, Harald Nothaft, Sthefany M. Chavez, Guillaume Goyette-Desjardins, Jeremy P. Huynh, Rachel L. Kinsella, Nichollas E. Scott, Mohamed Adel Nasr, Mariela Segura
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Chemical synthesis of conjugate vaccines, consisting of a polysaccharide linked to a protein, can be technically challenging, and in vivo bacterial conjugations (bioconjugations) have emerged as manufacturing alternatives. Bioconjugation relies upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9d6c1156d66addc38995515b791043
https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c
https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c
Publikováno v:
Glycobiology
Bioconjugate vaccines, consisting of polysaccharides attached to carrier proteins, are enzymatically generated using prokaryotic glycosylation systems in a process termed bioconjugation. Key to bioconjugation are a group of enzymes known as oligosacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a4593bb3422d37b5306010daf48d05
https://doi.org/10.1093/glycob/cwab043
https://doi.org/10.1093/glycob/cwab043
Publikováno v:
The Journal of Immunology. 208:181.08-181.08
Klebsiella pneumoniae (Kp) infections are sharply on the rise among at-risk populations. We have previously shown that use of bioconjugate vaccines targeting Kp are beneficial in preventing disease and seek to increase our vaccine breadth of coverage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d78e5f6fd73dc1a1592f0c051f6b917f
https://doi.org/10.4049/jimmunol.208.supp.181.08
https://doi.org/10.4049/jimmunol.208.supp.181.08
Autor:
Christian M. Harding, Erin N. Tracy, Michael D. Carruthers, Philip N. Rather, Luis A. Actis, Robert S. Munson
Publikováno v:
mBio, Vol 4, Iss 4 (2013)
ABSTRACT Acinetobacter baumannii is a Gram-negative, opportunistic pathogen. Recently, multiple A. baumannii genomes have been sequenced; these data have led to the identification of many genes predicted to encode proteins required for the biogenesis
Externí odkaz:
https://doaj.org/article/d5f14372497d4f23ac3112f703a03c76