Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Christian Luebbert"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 6, Iss , Pp 100207- (2023)
Amorphous solid dispersions (ASDs) are a widely used formulation technology for poorly water-soluble active pharmaceutical ingredients (API). Depending on the API-polymer combination and API load in the ASD, the amorphous API might be thermodynamical
Externí odkaz:
https://doaj.org/article/01f0d5f2fe924b489edd89ca8feb045b
Autor:
Christian Luebbert, Edmont Stoyanov
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100187- (2023)
Amorphous solid dispersion (ASD) formulations are preferred enabling formulations for poorly water soluble active pharmaceutical ingredients (API) as they reliably enhance the dissolution behavior and solubility. Balancing a high stability against un
Externí odkaz:
https://doaj.org/article/0e670150e79e4e01ac8e66a30483bb80
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100070- (2021)
Novel polymeric carriers for amorphous solid dispersions (ASDs) are highly demanded in pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates. Besides established polymer candidates, hydroxypropyl celluloses (HPC) co
Externí odkaz:
https://doaj.org/article/e2d8f703d1564e4c90a11e373f3ee783
Autor:
Stefanie Dohrn, Pranay Rawal, Christian Luebbert, Kristin Lehmkemper, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100072- (2021)
Amorphous solid dispersions (ASDs) are commonly manufactured using spray-drying processes. The product quality can be decisively influenced by the choice of process parameters. Following the quality-by-design approach, the identification of the spray
Externí odkaz:
https://doaj.org/article/caf668c3cf8d4780b4a5c4dead240ad5
Autor:
Friederike Wolbert, Ineke-Katharina Fahrig, Tobias Gottschalk, Christian Luebbert, Markus Thommes, Gabriele Sadowski
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 269 (2022)
In formulation development, amorphous solid dispersions (ASD) are considered to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the crystallization of APIs often limits long-term stability and th
Externí odkaz:
https://doaj.org/article/7ca870a42aed4eae857d4547e36cbef0
Publikováno v:
Molecules, Vol 26, Iss 11, p 3176 (2021)
The presence of water in the form of relative humidity (RH) may lead to deliquescence of crystalline components above a certain RH, the deliquescence RH (DRH). Knowing the DRH values is essential, e.g., for the agrochemical industry, food industry, a
Externí odkaz:
https://doaj.org/article/7fbb24866cc84bc985c1f34364fea9bb
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 433 (2021)
Knowledge of the stability of pharmaceutical formulations against relative humidity (RH) is essential if they are to become pharmaceutical products. The increasing interest in formulating active pharmaceutical ingredients as stable co-crystals (CCs)
Externí odkaz:
https://doaj.org/article/e88d0c0cdd0e4cfe8f8f91fd7135ee5a
Publikováno v:
Molecules, Vol 22, Iss 2, p 296 (2017)
The long-term stability of pharmaceutical formulations of poorly-soluble drugs in polymers determines their bioavailability and therapeutic applicability. However, these formulations do not only often tend to crystallize during storage, but also tend
Externí odkaz:
https://doaj.org/article/6e0355159aa84621a574f375f29c86cb
Autor:
Friederike Wolbert, Klaudia Nikoleit, Miklas Steinbrink, Christian Luebbert, Gabriele Sadowski
Publikováno v:
Molecular Pharmaceutics. 19:2483-2494
Amorphous solid dispersions (ASDs), where an active pharmaceutical ingredient (API) is dissolved in a polymer, are a favored formulation technique to achieve sufficient bioavailability of poorly water-soluble APIs. The shelf life of such ASDs is ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7d40a512f0811c943061565cd9b701
https://doi.org/10.1021/acs.molpharmaceut.2c00188
https://doi.org/10.1021/acs.molpharmaceut.2c00188
Publikováno v:
Crystal Growth & Design. 21:4445-4455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7873af6cbe3ec9a80b79746faf8ed2b1
https://doi.org/10.1021/acs.cgd.1c00355
https://doi.org/10.1021/acs.cgd.1c00355