Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christian Lohasz"'
Autor:
Oanh T. P. Nguyen, Patrick M. Misun, Christian Lohasz, Jihyun Lee, Weijia Wang, Timm Schroeder, Andreas Hierlemann
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Existing first-line cancer therapies often fail to cope with the heterogeneity and complexity of cancers, so that new therapeutic approaches are urgently needed. Among novel alternative therapies, adoptive cell therapy (ACT) has emerged as a promisin
Externí odkaz:
https://doaj.org/article/2df92aee5c0b4e4c80dccfbb7889809f
Autor:
Christian Lohasz, Jacqueline Loretan, Dario Sterker, Ekkehard Görlach, Kasper Renggli, Paul Argast, Olivier Frey, Marion Wiesmann, Markus Wartmann, Martin Rausch, Andreas Hierlemann
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Understanding the pharmacokinetic/pharmacodynamic (PK/PD)-relationship of a drug candidate is key to determine effective, yet safe treatment regimens for patients. However, current testing strategies are inefficient in characterizing in vivo response
Externí odkaz:
https://doaj.org/article/c1abe40c761345fab661063030846a30
Autor:
Nassim Rousset, Christian Lohasz, Julia Alicia Boos, Patrick M. Misun, Fernando Cardes, Andreas Hierlemann
Publikováno v:
Micromachines, Vol 13, Iss 7, p 1124 (2022)
Microfluidic-drop networks consist of several stable drops—interconnected through microfluidic channels—in which organ models can be cultured long-term. Drop networks feature a versatile configuration and an air–liquid interface (ALI). This ALI
Externí odkaz:
https://doaj.org/article/9eca8713baf94edbb92cef4c05ec0001
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
In vitro screening methods for compound efficacy and toxicity to date mostly include cell or tissue exposure to preset constant compound concentrations over a defined testing period. Such concentration profiles, however, do not represent realistic in
Externí odkaz:
https://doaj.org/article/4d07911594ed4876804b74c397c000e8
Publikováno v:
Proceedings, Vol 1, Iss 4, p 497 (2017)
We present a microfluidic tilting platform with gravity-driven flow that enables culturing of three-dimensional microtissues under in vivo-like drug dosing regimens. In contrast to traditional, constant dosing regimens, the chip allows for gradual ch
Externí odkaz:
https://doaj.org/article/16ac87ce54644fc88fd6228bedeec0ed
Autor:
Furkan Gökçe, Alicia Kaestli, Christian Lohasz, Martina de Geus, Hans‐Michael Kaltenbach, Kasper Renggli, Beat Bornhauser, Andreas Hierlemann, Mario Modena
Publikováno v:
Advanced Healthcare Materials, 12 (6)
Despite increasing survival rates of pediatric leukemia patients over the past decades, the outcome of some leukemia subtypes has remained dismal. Drug sensitivity and resistance testing on patient-derived leukemia samples provide important informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9583b17ef7eb2d68e048d3bbb1c722d3
Publikováno v:
SLAS Technology. 24:79-95
Microphysiological systems hold the promise to increase the predictive and translational power of in vitro substance testing owing to their faithful recapitulation of human physiology. However, the implementation of academic developments in industria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ee03013d8c5f2231d0a19b6a87e896
https://doi.org/10.1177/2472630318802582
https://doi.org/10.1177/2472630318802582
Autor:
Andreas Hierlemann, Flavio Bonanini, Olivier Frey, Lisa Hoelting, Christian Lohasz, Kasper Renggli
Publikováno v:
Advanced biosystems. 4(11)
Drug-drug interactions (DDIs) occur when the pharmacological activity of one drug is altered by a second drug. As multimorbidity and polypharmacotherapy are becoming more common due to the increasing age of the population, the risk of DDIs is massive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1cfc98c4c77d1d25838fc0c75d0246
https://pubmed.ncbi.nlm.nih.gov/33073544
https://pubmed.ncbi.nlm.nih.gov/33073544
Publikováno v:
Proceedings, Vol 1, Iss 4, p 497 (2017)
Proceedings, 1 (4)
Proceedings, 1 (4)
We present a microfluidic tilting platform with gravity-driven flow that enables culturing of three-dimensional microtissues under in vivo-like drug dosing regimens. In contrast to traditional, constant dosing regimens, the chip allows for gradual ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe9fa0b7712fa90a243157b7ed014f8
https://doi.org/10.3390/proceedings1040497
https://doi.org/10.3390/proceedings1040497
Publikováno v:
Adv Biosyst
Studying and understanding of tissue and disease mechanisms largely depend on the availability of suitable and representative biological model systems. These model systems should be carefully engineered and faithfully reproduce the biological system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0c172d431569820d27554d9e10b5a4
https://doi.org/10.1002/adbi.201900018
https://doi.org/10.1002/adbi.201900018