Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Christian Loc'h"'
Autor:
Tien Pham, Naomi Wyatt, Ivan Greguric, Thanh Le, Michael J. Fulham, Filomena Mattner, Christopher J. R. Fookes, Andrew Katsifis, Timothy Jackson, Christian Loc'h, Tzong-Tyng Hung, Jackson Poon, Brendan Lee, Rachael Shepherd, David Henderson, Carl Power, Thomas Bourdier, Paula Berghofer
Publikováno v:
RSC Medicinal Chemistry. 12:1207-1221
Radiopharmaceuticals that target the translocator protein 18 kDa (TSPO) have been investigated with positron emission tomography (PET) to study neuroinflammation, neurodegeneration and cancer. We have developed the novel, achiral, 2-phenylimidazo[1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6624d71d8b68023aa408199d6bd3d34
https://doi.org/10.1039/d1md00035g
https://doi.org/10.1039/d1md00035g
Autor:
Filomena, Mattner, Andrew, Katsifis, Thomas, Bourdier, Christian, Loc'h, Paula, Berghofer, Christopher, Fookes, Tzong-Tyng, Hung, Timothy, Jackson, David, Henderson, Tien, Pham, Brendan J, Lee, Rachael, Shepherd, Ivan, Greguric, Naomi, Wyatt, Thanh, Le, Jackson, Poon, Carl, Power, Michael, Fulham
Publikováno v:
RSC Med Chem
Radiopharmaceuticals that target the translocator protein 18 kDa (TSPO) have been investigated with positron emission tomography (PET) to study neuroinflammation, neurodegeneration and cancer. We have developed the novel, achiral, 2-phenylimidazo[1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6344cf3c03eabeef7d23abcf73f3331
https://pubmed.ncbi.nlm.nih.gov/34355185
https://pubmed.ncbi.nlm.nih.gov/34355185
Autor:
Ivan Greguric, T. Pham, Terri Jackson, D. Zahra, Zeljko Pastuovic, Naomi Wyatt, Marie-Claude Gregoire, Thomas Bourdier, Andrew Katsifis, G. L. Rahardjo, Nicholas R. Howell, Rainer Siegele, Paul D. Callaghan, Christian Loc'h, Filomena Mattner, P. J. Berghofer, C. A. Wimberley
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 42:138-151
The in vivo binding parameters of the novel imidazopyridine TSPO ligand [(18)F]PBR102 were assessed and compared with those of [(18)F]PBR111 in a rodent model of neuroinflammation. The validity of the key assumptions of the simplified reference tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa0863dbbaf99be9f73c1e77d248f56
https://doi.org/10.1007/s00259-014-2895-3
https://doi.org/10.1007/s00259-014-2895-3
Autor:
Lucy Vivash, Christopher J. R. Fookes, Christian Loc'h, Rodney J. Hicks, Tien Pham, Ivan Greguric, Damian E. Myers, Stefanie Dedeurwaerdere, Peter Roselt, Terence J. O'Brien, Marie-Claude Gregoire, David Binns, Andrew Katsifis
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 36:958-965
[(11)C]Flumazenil shows promise as a clinical and research PET radiotracer to image changes in GABA(A) central benzodiazepine receptor (cBZR), but its widespread use has been limited by practical limitations of [(11)C]. This study evaluated the imagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5ce98b40d0622586c48beb3315d05c
https://doi.org/10.1007/s00259-009-1066-4
https://doi.org/10.1007/s00259-009-1066-4
Publikováno v:
Life Sciences. 79:287-294
In vitro binding of the iodinated imidazopyri dine, N',N'-dimethyl-6-methyl-(4'-[I-123]iodophenyl)imidazo[1,2-a]pyridine-3-acetamide [I-123]IZOL to benzodiazepine binding sites on brain cortex, adrenal and kidney membranes is reported. Saturation exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6009875b50241e29cf4e269d1511eee
https://doi.org/10.1016/j.lfs.2006.01.006
https://doi.org/10.1016/j.lfs.2006.01.006
Publikováno v:
Applied Radiation and Isotopes. 64:27-31
A simplified method for the rapid and efficient preparation of [(123)I]radiopharmaceuticals is described. Three radiopharmaceuticals, [(123)I]beta-CIT, [(123)I]MIBG and [(123)I]clioquinol, were synthesised and purified as model compounds. The radiotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35d797e530a3daf244ce9516aaa8720
https://doi.org/10.1016/j.apradiso.2005.06.006
https://doi.org/10.1016/j.apradiso.2005.06.006
Autor:
Victor L. Villemagne, Andrew Katsifis, Terri Jackson, Vahan Papazian, T. Pham, Christopher C. Rowe, Christian Loc'h, C.L. Masters, Ivan Greguric, Xiang Liu
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:473-484
Clioquinol or 5-chloro-7-iodo-8-hydroxyquinoline (CQ) is a lipophilic hydroxyquinoline currently under investigation for the treatment of Alzheimer's disease by targeted copper and zinc chelation. CQ was radiolabelled with no-carrier-added iodine-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e50611c7989902aaf930f343b026a9ca
https://doi.org/10.1002/jlcr.942
https://doi.org/10.1002/jlcr.942
Autor:
Frédéric Dollé, Michael Kassiou, L Dolci, John L. Musachio, Christian Crouzel, Christian Loc'h, Robert F. Dannals, Bernard Maziere
Publikováno v:
Applied Radiation and Isotopes. 57:713-717
Epibatidine analogues have been labelled with I-123 for single photon emission computed tomography and with short half-life positron emitters (C-11 and F-18) for PET. For easier radiopharmacological studies the bromo analogue of epibatidine (norchlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da4083b6bc62e72f6c88dfff73984d0
https://doi.org/10.1016/s0969-8043(02)00187-2
https://doi.org/10.1016/s0969-8043(02)00187-2
Autor:
F. Riche, F. Turpin, N. Neuquelman, Fadi Masri, Patrick Emond, E. Berthommier, Christian Loc'h, Philippe Auzeloux, Laurent Mauclaire, M. Vidal
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:379-393
In order to visualize and quantify dopamine transporters, the synthesis of two novel ligands labelled with technetium-99 m (99mTc) has been investigated. A multi-step synthesis afforded two target ligands with a tropane skeleton and a macrocyclic com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90f8e9d5c3fbddc07fa6355539f9a03c
https://doi.org/10.1002/jlcr.560
https://doi.org/10.1002/jlcr.560
Autor:
H. Dao Boulanger, Sylvie Chalon, Laurent Mauclaire, E. Berthommier, C. Olivier, P. Emond, Christian Loc'h, M.A. Lelait
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:1019-1028
In order to simplify preparation of [123I]PE2I, iodogen and hydrogen peroxide were examined as oxidants for the preparation of radioiodinated PE2I, e.g. (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl) nortropane). Among the oxidizing comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d9d9c0808d0327d65bad4825c3543fc
https://doi.org/10.1002/jlcr.620
https://doi.org/10.1002/jlcr.620