Golgi localization of SARS-CoV-2 spike protein and interaction with furin in cerebral COVID-19 microangiopathy: a clue to the central nervous system involvement?

Autor: Susana Boluda, Karima Mokhtari, Bruno Mégarbane, Djillali Annane, Bertrand Mathon, Albert Cao, Clovis Adam, Alexandre Androuin, Franck Bielle, Guy Brochier, Frédéric Charlotte, Lydia Chougar, Khalid Hamid El Hachimi, Marc Eloit, Stéphane Haïk, Dominique Hervé, Amal Kasri, Valentin Leducq, Stéphane Lehéricy, Etienne Levavasseur, Christian Lobsiger, Geoffroy Lorin de La Grandmaison, Isabelle Malet, Isabelle Malissin, Stéphane Marot, Serge Marty, Philippe Pérot, Isabelle Plu, Annick Prigent, Lev Stimmer, Marie-Claude Potier, Anne-Geneviève Marcelin, Benoît Delatour, Charles Duyckaerts, Danielle Seilhean

Publikováno v: Free Neuropathology, Vol 4 (2023)

In a neuropathological series of 20 COVID-19 cases, we analyzed six cases (three biopsies and three autopsies) with multiple foci predominantly affecting the white matter as shown by MRI. The cases presented with microhemorrhages evocative of small a

Externí odkaz: https://doaj.org/article/05edf363d5d14e9389cc5d0000462bdb

Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca 2+

Autor: Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C. Hirsch, Patrick P. Michel, Damien Toulorge

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2011, 25 (8), pp.2563-2573. ⟨10.1096/fj.11-182824⟩
FASEB Journal, 2011, 25 (8), pp.2563-2573. ⟨10.1096/fj.11-182824⟩

International audience; Epidemiological and experimental evidence indicates that nicotine is protective for Parkinson disease vulnerable dopamine neurons, but the underlying mechanism of this effect remains only partly characterized. To address this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe983786ed6f0f549846665d2f38a730
https://hal-pasteur.archives-ouvertes.fr/pasteur-02936389