Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Christian Litke"'
Autor:
Christian Litke, Anna M. Hagenston, Ann-Kristin Kenkel, Eszter Paldy, Jianning Lu, Rohini Kuner, Daniela Mauceri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Chronic pain is sustained by alterations in gene transcription. Here, the authors show that increased expression of Organic Anionic Transporter 1 in the spinal cord is epigenetically controlled and key to hypersensitivity in pathological pain.
Externí odkaz:
https://doaj.org/article/c8bf8de042c34234829d98c2faafcb92
Autor:
Aynur Sönmez, Rasem Mustafa, Salome T. Ryll, Francesca Tuorto, Ludivine Wacheul, Donatella Ponti, Christian Litke, Tanja Hering, Kerstin Kojer, Jenniver Koch, Claudia Pitzer, Joachim Kirsch, Andreas Neueder, Grzegorz Kreiner, Denis L. J. Lafontaine, Michael Orth, Birgit Liss, Rosanna Parlato
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract Transcriptional and cellular-stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal-dominant neurodegenerative disorder caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The
Externí odkaz:
https://doaj.org/article/ef5389a9059145348fc5353ee8922ca1
Autor:
Soenmez A, Francesca Tuorto, Andreas Neueder, Ludivine Wacheul, Grzegorz Kreiner, Tanja Hering, Rasem Mustafa, Ryll St, Birgit Liss, Michael Orth, Ponti D, Christian Litke, Rosanna Parlato, Joachim Kirsch, Koch J, Claudia Pitzer, Kerstin Kojer, Denis L. J. Lafontaine
Transcriptional and cellular stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal dominant neurodegenerative disorder, caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The nucleol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7267a27c2fdbe60d311554532f71f85
https://doi.org/10.1101/2021.07.09.451766
https://doi.org/10.1101/2021.07.09.451766
Autor:
Aynur Sönmez, Tanja Hering, Salome Tabea Spieth, Kerstin Kojer, Christian Litke, Birgit Liss, Jenniver Koch, Rosanna Parlato, Michael Orth, Rasem Mustafa
Publikováno v:
Pathogenic mechanisms.
Background Transcriptional and metabolic dysregulation are known to occur in Huntington’s disease (HD). Mutant huntingtin (mHTT) protein affects several cellular functions hindering the identification of the primary pathogenic event. Impaired trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e1297b95b321ba01f009910ca0a4ac
https://doi.org/10.1136/jnnp-2018-ehdn.9
https://doi.org/10.1136/jnnp-2018-ehdn.9
Publikováno v:
The Journal of biological chemistry. 293(21)
Nucleo-cytoplasmic shuttling of class IIa histone deacetylases (i.e. HDAC4, -5, -7, and -9) is a synaptic activity- and nuclear calcium–dependent mechanism important for epigenetic regulation of signal-regulated gene expression in hippocampal neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22bced3194599f71cda34a2ac19c444
https://pubmed.ncbi.nlm.nih.gov/29632070
https://pubmed.ncbi.nlm.nih.gov/29632070
Autor:
Aynur Soenmez, Holger Bierhoff, Rasem Mustafa, Jose E. Naranjo, Rosanna Parlato, Salome Tabea Spieth, Grzegorz Kreiner, Francesca Tuorto, Birgit Liss, Christian Litke
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A16.1-A16
Background The expansion of CAG repeats in the mutant huntingtin (mHtt) protein impairs, among other fundamental cellular functions, the transcription of rRNA genes causing inhibition of rRNA synthesis and consequent disruption of nucleolar integrity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481865e8f86441234eab5e82c97b5c91
https://doi.org/10.1136/jnnp-2016-314597.51
https://doi.org/10.1136/jnnp-2016-314597.51