Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Christian Legros"'
Autor:
Ranin Dabbousy, Mohamad Rima, Rabih Roufayel, Mohamad Rahal, Christian Legros, Jean-Marc Sabatier, Ziad Fajloun
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1307 (2024)
Drug development from medicinal plants constitutes an important strategy for finding natural anticancer therapies. While several plant secondary metabolites with potential antitumor activities have been identified, well-defined mechanisms of action r
Externí odkaz:
https://doaj.org/article/8e6f6b20f1ca452c8ef1b86c241cded0
Publikováno v:
Toxins, Vol 16, Iss 3, p 147 (2024)
The French Society of Toxinology (SFET), which celebrated its 30th anniversary this year, organized its 29th annual Meeting (RT29), shared by 87 participants, on 30 November–1 December 2023. The RT29 main theme, “Toxins: From the Wild to the Lab
Externí odkaz:
https://doaj.org/article/7fdbad469c954d53a95c99bf169b7655
Autor:
Jacinthe Frangieh, Claire Legendre, Dimitri Bréard, Pascal Richomme, Daniel Henrion, Ziad Fajloun, César Mattei, Anne-Marie Le Ray, Christian Legros
Publikováno v:
Future Pharmacology, Vol 2, Iss 3, Pp 238-255 (2022)
The isoquinoline alkaloids (IAs) represent a large and diverse subfamily of phytochemicals in terms of structures and pharmacological activities, including ion channel inhibition. Several IAs, such as liriodenine (an oxoaporphine) and curine (a bisbe
Externí odkaz:
https://doaj.org/article/43c57006fac940fa92c0ad04aeb47dbd
Autor:
Sara Nasr, Adolfo Borges, Christina Sahyoun, Riad Nasr, Rabih Roufayel, Christian Legros, Jean-Marc Sabatier, Ziad Fajloun
Publikováno v:
Antibiotics, Vol 12, Iss 9, p 1380 (2023)
Scorpion venoms have long captivated scientific researchers, primarily due to the potency and specificity of the mechanism of action of their derived components. Among other molecules, these venoms contain highly active compounds, including antimicro
Externí odkaz:
https://doaj.org/article/5fb24cad93ed446597976702e81f0090
Autor:
Joohee Park, Coralyne Proux, William Ehanno, Léa Réthoré, Emilie Vessières, Jennifer Bourreau, Julie Favre, Gilles Kauffenstein, César Mattei, Hélène Tricoire-Leignel, Daniel Henrion, Claire Legendre, Christian Legros
Publikováno v:
Marine Drugs, Vol 21, Iss 3, p 196 (2023)
Tetrodotoxin (TTX) poisoning through the consumption of contaminated fish leads to lethal symptoms, including severe hypotension. This TTX-induced hypotension is likely due to the downfall of peripheral arterial resistance through direct or indirect
Externí odkaz:
https://doaj.org/article/2fbb2051a545447cbba965abcbc60473
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/ecd021d98aa543bbb011bd712d19dc95
Autor:
Zineb Soualah, Antoine Taly, Lucille Crespin, Ophélie Saulais, Daniel Henrion, Claire Legendre, Hélène Tricoire-Leignel, Christian Legros, César Mattei
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Fipronil (FPN) is a worldwide-used neurotoxic insecticide, targeting, and blocking GABAA receptors (GABAARs). Beyond its efficiency on insect GABAARs, FPN causes neurotoxic effects in humans and mammals. Here, we investigated the mode of action of FP
Externí odkaz:
https://doaj.org/article/ceb9ff75ecb04493bc3f8dee993d1132
Autor:
Christina Sahyoun, Wojciech Krezel, César Mattei, Jean-Marc Sabatier, Christian Legros, Ziad Fajloun, Mohamad Rima
Publikováno v:
Biology, Vol 11, Iss 6, p 888 (2022)
The complications following snake bite envenoming are due to the venom’s biological activities, which can act on different systems of the prey. These activities arise from the fact that snake venoms are rich in bioactive molecules, which are also o
Externí odkaz:
https://doaj.org/article/6648a183f7074e01bba5a62113ee3059
Autor:
Quentin Coquerel, Claire Legendre, Jacinthe Frangieh, Stephan De Waard, Jérôme Montnach, Leos Cmarko, Joseph Khoury, Charifat Said Hassane, Dimitri Bréard, Benjamin Siegler, Ziad Fajloun, Harold De Pomyers, Kamel Mabrouk, Norbert Weiss, Daniel Henrion, Pascal Richomme, César Mattei, Michel De Waard, Anne-Marie Le Ray, Christian Legros
Publikováno v:
Molecules, Vol 27, Iss 13, p 4133 (2022)
Voltage-gated Na+ (NaV) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting the search for novel NaV channel ligands. With the objective of discovering new blockers of NaV channel ligan
Externí odkaz:
https://doaj.org/article/3c3824003c5c472796fb3122b1c94452
Autor:
Shaymaa Khazaal, Julien Harb, Mohamad Rima, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Ziad Abi Khattar, Christian Legros, Hervé Kovacic, Ziad Fajloun, Jean-Marc Sabatier
Publikováno v:
Molecules, Vol 27, Iss 9, p 2903 (2022)
COVID-19 has expanded across the world since its discovery in Wuhan (China) and has had a significant impact on people’s lives and health. Long COVID is a term coined by the World Health Organization (WHO) to describe a variety of persistent sympto
Externí odkaz:
https://doaj.org/article/996553a3a4a749fbbea9c33c865d1e73