Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Christian Le Gouill"'
Autor:
Florence Gross, Arturo Mancini, Billy Breton, Hiroyuki Kobayashi, Pedro Henrique Scarpelli Pereira, Christian Le Gouill, Michel Bouvier, Stephan Schann, Xavier Leroy, Laurent Sabbagh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Mutations of receptor tyrosine kinases (RTKs) are associated with the development of many cancers by modifying receptor signaling and contributing to drug resistance in clinical settings. We present enhanced bystander bioluminescence resonan
Externí odkaz:
https://doaj.org/article/0cc3d5d503574ee798e91bfae6c8edd3
Autor:
Shane C. Wright, Aikaterini Motso, Stefania Koutsilieri, Christian M. Beusch, Pierre Sabatier, Alessandro Berghella, Élodie Blondel-Tepaz, Kimberley Mangenot, Ioannis Pittarokoilis, Despoina-Christina Sismanoglou, Christian Le Gouill, Jesper V. Olsen, Roman A. Zubarev, Nevin A. Lambert, Alexander S. Hauser, Michel Bouvier, Volker M. Lauschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating therapeutic signaling from signaling associated with adverse events is an important step tow
Externí odkaz:
https://doaj.org/article/87f6a5fc98af40a19909134b0c703db6
Autor:
Aliza T. Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L. Kieffer
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known abou
Externí odkaz:
https://doaj.org/article/c691042905314379a42058d6da6d43ec
Autor:
Charlotte Avet, Arturo Mancini, Billy Breton, Christian Le Gouill, Alexander S Hauser, Claire Normand, Hiroyuki Kobayashi, Florence Gross, Mireille Hogue, Viktoriya Lukasheva, Stéphane St-Onge, Marilyn Carrier, Madeleine Héroux, Sandra Morissette, Eric B Fauman, Jean-Philippe Fortin, Stephan Schann, Xavier Leroy, David E Gloriam, Michel Bouvier
Publikováno v:
eLife, Vol 11 (2022)
The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins and βarrestins are a
Externí odkaz:
https://doaj.org/article/34e18aa1566b4e768be5932a0e81dff7
Autor:
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma Van Der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Identifying ligands which activate the specific effectors driving particular in vivo drug effects remains challenging. Here, the authors apply unsupervised clustering of pharmacodynamic parameters to classify GPCR ligands into different categories wi
Externí odkaz:
https://doaj.org/article/c0db3f1cf110426bbd5f35d40fd3681b
Autor:
Aliza T. Ehrlich, Meriem Semache, Florence Gross, Dillon F. Da Fonte, Leonie Runtz, Christine Colley, Amina Mezni, Christian Le Gouill, Viktoriya Lukasheva, Mireille Hogue, Emmanuel Darcq, Michel Bouvier, Brigitte L. Kieffer
Publikováno v:
iScience, Vol 14, Iss , Pp 47-57 (2019)
Summary: G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals. The concept of ligand-dependent biased signaling raises the possibility of developing drugs with improved efficacy and safety profiles, yet transl
Externí odkaz:
https://doaj.org/article/88fbd700e88446eda04c7bc96f781810
Autor:
Anne-Marie Schönegge, Jonathan Gallion, Louis-Philippe Picard, Angela D. Wilkins, Christian Le Gouill, Martin Audet, Wayne Stallaert, Martin J. Lohse, Marek Kimmel, Olivier Lichtarge, Michel Bouvier
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Ligand-induced biased signaling is thought to result in part from ligand-specific receptor conformations that cause the engagement of distinct effectors. Here the authors trace and evaluate the impact of mutations of the β2–adrenergic receptor on
Externí odkaz:
https://doaj.org/article/998b6cae615e45acb325e0d14982a595
Autor:
Yoon Namkung, Christian Le Gouill, Viktoria Lukashova, Hiroyuki Kobayashi, Mireille Hogue, Etienne Khoury, Mideum Song, Michel Bouvier, Stéphane A. Laporte
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Cellular signaling processes often involve trafficking of receptors and other proteins between subcellular compartments. Here the authors demonstrate a method based on the concept of Enhanced bystander Bioluminescence Resonance Energy Transfer (EbBRE
Externí odkaz:
https://doaj.org/article/533dd58c08184acea1bdb815fa853d15
Autor:
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma Van Der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1f09235de66f4fc295108bc582f6d396
Publikováno v:
Mediators of Inflammation, Vol 12, Iss 1, Pp 29-35 (2003)
The objective of this study was to test the hypothesis that an oxidative stress can serve as a signal to regulate the expression of CCR5. When human monocytes were exposed to graded concentration of hydrogen peroxide (H2O2), CCR5 mRNA levels increase
Externí odkaz:
https://doaj.org/article/fe0174f72ac646caa10c034a39fba055