Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christian Latza"'
Autor:
Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Adam Antebi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Metabolic pathways are closely intertwined with longevity. Here the authors perform metabolomic profiling of canonical longevity pathways and show that folate and methionine cycle intermediates are changed in common, and further, genetic manipulation
Externí odkaz:
https://doaj.org/article/df062d6b3abf45a7848081ae8c84ee62
Autor:
Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Sebastian Grönke, Linda Partridge, Adam Antebi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/85839c6a6329493898febc5a229840ea
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
Autor:
Shuhei Nakamura, Özlem Karalay, Philipp S. Jäger, Makoto Horikawa, Corinna Klein, Kayo Nakamura, Christian Latza, Sven E. Templer, Christoph Dieterich, Adam Antebi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating
Externí odkaz:
https://doaj.org/article/d64ac3f9db434a949312fa7d63fb441c
Autor:
Roberto Ripa, Eugen Ballhysa, Joachim D. Steiner, Andrea Annibal, Nadine Hochhard, Christian Latza, Luca Dolfi, Chiara Calabrese, Anna M. Meyer, M. Cristina Polidori, Roman-Ulrich Müller, Adam Antebi
Late-life-initiated dietary interventions negligibly extend longevity or reduce frailty, yet the reason remains unknown. We investigated the age-related changes associated with the fasting response in adipose tissue of the short-lived killifishN. fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f44dd41d9f37f3cba97782f64258cb33
https://doi.org/10.1101/2022.12.05.519139
https://doi.org/10.1101/2022.12.05.519139
Publikováno v:
Anal Bioanal Chem
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry
Cyclic dinucleotides (CDNs) are key secondary messenger molecules produced by cyclic dinucleotide synthases that trigger various cellular signaling cascades from bacteria to vertebrates. In mammals, cyclic GMP-AMP synthase (cGAS) has been shown to bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5099e9710cc3316844668d5ec51cc104
https://doi.org/10.1007/s00216-021-03628-6
https://doi.org/10.1007/s00216-021-03628-6
Autor:
Hannah Tam, Sebastian Grönke, Linda Partridge, Andrea Annibal, Markus Max Karl Auler, Adam Antebi, Christian Latza, Rebecca George Tharyan, Maribel Fides Schonewolff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nat Commun
Nature Communications
Nat Commun
Nature Communications
The metabolome represents a complex network of biological events that reflects the physiologic state of the organism in health and disease. Additionally, specific metabolites and metabolic signaling pathways have been shown to modulate animal ageing,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e32bdcc9227b41a74743ce3e94a5788
https://doaj.org/article/df062d6b3abf45a7848081ae8c84ee62
https://doaj.org/article/df062d6b3abf45a7848081ae8c84ee62
Publikováno v:
J Mass Spectrom
Folic acid (FA) plays a vital role in central metabolism, including the one carbon cycle, nucleotide, and amino acid biosynthesis. The development of sensitive, accurate analytical methods to measure FA intermediates in tissues is critical to underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c237498028211919b2a5fd83f268d89
https://doi.org/10.1002/jms.4337
https://doi.org/10.1002/jms.4337
Autor:
Sara A. Wickström, Andromachi Pouikli, Martin S. Denzel, Carlos Andrés Chacón-Martínez, Peter Tessarz, K. Allmeroth, Andrea Annibal, Christian Latza, Adam Antebi, Christine S. Kim
Stem cell differentiation is accompanied by an increase in mRNA translation. The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine, and spermine that are essential for cell growth and stem cell maintenance. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14aa5000f467d3b916e61c25dad14615
https://doi.org/10.1101/2020.04.30.070201
https://doi.org/10.1101/2020.04.30.070201
Publikováno v:
Analytical and Bioanalytical Chemistry
Anal Bioanal Chem
Anal Bioanal Chem
Steroids are essential structural components of cell membranes that organize lipid rafts and modulate membrane fluidity. They can also act as signalling molecules that work through nuclear and G protein–coupled receptors to impact health and diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfb00b6bb9a8f7f22a84e4cc42929e1
https://pubmed.ncbi.nlm.nih.gov/32333075
https://pubmed.ncbi.nlm.nih.gov/32333075
Publikováno v:
Analytical Methods
Endocannabinoids and related N-acyl ethanolamine-derived lipids affect a diverse array of physiological processes and pathological conditions. In the roundworm C. elegans, several endocannabinoid-like molecules have been implicated in regulating axon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919fb71d61939564f6c2cc8f965cde0c
https://hdl.handle.net/21.11116/0000-0004-71F1-C
https://hdl.handle.net/21.11116/0000-0004-71F1-C