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Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia
Autor:
Christian Lassmann, Winfried Ilg, Tim W. Rattay, Ludger Schöls, Martin Giese, Daniel F. B. Haeufle
Publikováno v:
Journal of NeuroEngineering and Rehabilitation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background In Hereditary Spastic Paraplegia (HSP) type 4 (SPG4) a length-dependent axonal degeneration in the cortico-spinal tract leads to progressing symptoms of hyperreflexia, muscle weakness, and spasticity of lower extremities. Even bef
Externí odkaz:
https://doaj.org/article/922b97fb95b94dc6a54c0d6b5172dac1
Autor:
Christian Laßmann, Winfried Ilg, Marc Schneider, Maximilian Völker, Daniel F. B. Haeufle, Rebecca Schüle, Martin Giese, Ludger Schöls, Tim W. Rattay
BackgroundIn hereditary spastic paraplegia type 4 (SPG4), subclinical gait changes might occur years before patients realize gait disturbances. The prodromal phase of neurodegenerative disease is of particular interest to halt disease progression by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df28d9758224b37ba5ecf48945946e20
https://doi.org/10.1101/2022.04.20.22274071
https://doi.org/10.1101/2022.04.20.22274071
Autor:
Christian Laßmann, Winfried Ilg, Marc Schneider, Maximilian Völker, Daniel F.B. Haeufle, Rebecca Schüle, Martin Giese, Matthis Synofzik, Ludger Schöls, Tim W. Rattay
Publikováno v:
Movement Disorders
Movement disorders 37(12), 2417-2426 (2022). doi:10.1002/mds.29199
Movement disorders 37(12), 2417-2426 (2022). doi:10.1002/mds.29199
In hereditary spastic paraplegia type 4 (SPG4), subclinical gait changes might occur years before patients realize gait disturbances. The prodromal phase of neurodegenerative disease is of particular interest to halt disease progression by future int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced4a19dccaecd1671a01ed4505281df