Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Christian Landles"'
Autor:
Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Abstract Huntington’s disease (HD) is a late onset, inherited neurodegenerative disorder for which early pathogenic events remain poorly understood. Here we show that mutant exon 1 HTT proteins are recruited to a subset of cytoplasmic aggregates in
Externí odkaz:
https://doaj.org/article/0cbf701f6cb54600ae9ad669c9f4899d
Autor:
Andreas Neueder, Christian Landles, Rhia Ghosh, David Howland, Richard H. Myers, Richard L. M. Faull, Sarah J. Tabrizi, Gillian P. Bates
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract We have previously shown that exon 1 of the huntingtin gene does not always splice to exon 2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein. The level of this read-
Externí odkaz:
https://doaj.org/article/880697bfb72a45d88a4cbeba52640f2d
Autor:
Michal Mielcarek, Christian Landles, Andreas Weiss, Amyaouch Bradaia, Tamara Seredenina, Linda Inuabasi, Georgina F Osborne, Kristian Wadel, Chrystelle Touller, Rachel Butler, Janette Robertson, Sophie A Franklin, Donna L Smith, Larry Park, Paul A Marks, Erich E Wanker, Eric N Olson, Ruth Luthi-Carter, Herman van der Putten, Vahri Beaumont, Gillian P Bates
Publikováno v:
PLoS Biology, Vol 11, Iss 11, p e1001717 (2013)
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused
Externí odkaz:
https://doaj.org/article/36f0a78b62114715a37984063f3cb2d9
Autor:
Michal Mielcarek, Tamara Seredenina, Matthew P Stokes, Georgina F Osborne, Christian Landles, Linda Inuabasi, Sophie A Franklin, Jeffrey C Silva, Ruth Luthi-Carter, Vahri Beaumont, Gillian P Bates
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80849 (2013)
Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone de
Externí odkaz:
https://doaj.org/article/b5485e4f250441ab8eb9ed5c1535835b
Autor:
Gijs Teklenburg, Madhuri Salker, Mariam Molokhia, Stuart Lavery, Geoffrey Trew, Tepchongchit Aojanepong, Helen J Mardon, Amali U Lokugamage, Raj Rai, Christian Landles, Bernard A J Roelen, Siobhan Quenby, Ewart W Kuijk, Annemieke Kavelaars, Cobi J Heijnen, Lesley Regan, Jan J Brosens, Nick S Macklon
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10258 (2010)
Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a receptive endometrium. Reproductive success in humans is however limited, largely because of the
Externí odkaz:
https://doaj.org/article/b5367540c86a41c39c1b7169889fd6c0
Autor:
Madhuri Salker, Gijs Teklenburg, Mariam Molokhia, Stuart Lavery, Geoffrey Trew, Tepchongchit Aojanepong, Helen J Mardon, Amali U Lokugamage, Raj Rai, Christian Landles, Bernard A J Roelen, Siobhan Quenby, Ewart W Kuijk, Annemieke Kavelaars, Cobi J Heijnen, Lesley Regan, Nick S Macklon, Jan J Brosens
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10287 (2010)
Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus or to uterine factors that are poorly defined. We tested the hypothesis that abnormal cycl
Externí odkaz:
https://doaj.org/article/561f04d2ecfb485aa97a0e4a309e75a4
Autor:
Sandra Fienko, Christian Landles, Kirupa Sathasivam, Sean J McAteer, Rebecca E Milton, Georgina F Osborne, Edward J Smith, Samuel T Jones, Marie K Bondulich, Emily C E Danby, Jemima Phillips, Bridget A Taxy, Holly B Kordasiewicz, Gillian P Bates
Publikováno v:
Brain. 145:4409-4424
Huntington disease is caused by a CAG repeat expansion in exon 1 of the huntingtin gene (HTT) that is translated into a polyglutamine stretch in the huntingtin protein (HTT). We previously showed that HTT mRNA carrying an expanded CAG repeat was inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45e092a75a5ea5192081081d74bcd73
https://doi.org/10.1093/brain/awac241
https://doi.org/10.1093/brain/awac241
Autor:
Edward J Smith, Kirupa Sathasivam, Christian Landles, Georgina F Osborne, Michael A Mason, Casandra Gomez-Paredes, Bridget A Taxy, Rebecca E Milton, Anne Ast, Franziska Schindler, Chuangchuang Zhang, Wenzhen Duan, Erich E Wanker, Gillian P Bates
Publikováno v:
Brain Communications. 5
Huntingtin-lowering approaches that target huntingtin expression are a major focus for therapeutic intervention for Huntington’s disease. When the cytosine, adenine and guanine repeat is expanded, the huntingtin pre-mRNA is alternatively processed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd1b81d208a5d41288fd74703b011ea
https://doi.org/10.1093/braincomms/fcad010
https://doi.org/10.1093/braincomms/fcad010
Autor:
Sandra Fienko, Christian Landles, Kirupa Sathasivam, Casandra Gomez-Paredes, Sean McAteer, Rebecca Milton, Georgina F Osborne, Samuel T Jones, Jemima M Phillips, Holly B Kordasiewicz, Gillian P Bates
Publikováno v:
A: Pathogenic mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54208c4f30fbbfa23713f23b19563872
https://doi.org/10.1136/jnnp-2022-ehdn.3
https://doi.org/10.1136/jnnp-2022-ehdn.3
Autor:
Christian Landles, Georgina F Osborne, Rebecca E Milton, Alexandre Jean, Stuart McLarnon, Chuangchuang Zhang, Wenzhen Duan, Gillian P Bates
Publikováno v:
D: Wet biomarkers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e99220af9465618ef65117888432c7e
https://doi.org/10.1136/jnnp-2022-ehdn.59
https://doi.org/10.1136/jnnp-2022-ehdn.59