Recalibrating disease parameters for increasing realism in modeling epidemics in closed settings

Autor: Livio Bioglio, Mathieu Génois, Christian L. Vestergaard, Chiara Poletto, Alain Barrat, Vittoria Colizza

Publikováno v: BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-15 (2016)

Abstract Background The homogeneous mixing assumption is widely adopted in epidemic modelling for its parsimony and represents the building block of more complex approaches, including very detailed agent-based models. The latter assume homogeneous mi

Externí odkaz: https://doaj.org/article/3e01054fbaeb4e7b973193f032d12162

Intracellular signalling by diffusion: Can waves of hydrogen peroxide transmit intracellular information in plant cells?

Autor: Christian L. Vestergaard, Henrik eFlyvbjerg, Ian Max Møller

Publikováno v: Frontiers in Plant Science, Vol 3 (2012)

Amplitude- and frequency-modulated waves of Ca2+ ions transmit information inside cells. Reactive Oxygen Species, specifically hydrogen peroxide, have been proposed a similar role in plant cells. We consider the feasibility of such an intracellular c

Externí odkaz: https://doaj.org/article/d1fab8c2fec74ac78ecae47a7e901dab

A maximum mean discrepancy approach reveals subtle changes in α-synuclein dynamics

Autor: Hippolyte Verdier, François Laurent, Alhassan Cassé, Christian L. Vestergaard, Christian G. Specht, Jean-Baptiste Masson

Numerous models have been developed to account for the complex properties of the random walks of biomolecules. However, when analysing experimental data, conditions are rarely met to ensure model identification. The dynamics may simultaneously be inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a808a103fb3202e78fce66ce69df600
https://doi.org/10.1101/2022.04.11.487825

Hematopoietic stem cell transplantation chemotherapy causes microglia senescence and peripheral macrophage engraftment in the brain

Autor: Kurt A. Sailor, George Agoranos, Sergio López-Manzaneda, Satoru Tada, Beatrix Gillet-Legrand, Corentin Guerinot, Jean-Baptiste Masson, Christian L. Vestergaard, Melissa Bonner, Khatuna Gagnidze, Gabor Veres, Pierre-Marie Lledo, Nathalie Cartier

Publikováno v: Nature Medicine
Nature Medicine, 2022, ⟨10.1038/s41591-022-01691-9⟩

International audience; Hematopoietic stem cell transplantation (HSCT) is a therapy used for multiple malignant and nonmalignant diseases, with chemotherapy used for pretransplantation myeloablation. The post-HSCT brain contains peripheral engrafted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d2fbb2686bae310ff975bb4318d650
https://hal-pasteur.archives-ouvertes.fr/pasteur-03588683

Statistical Tests for Force Inference in Heterogeneous Environments

Autor: François Laurent, Jean-Baptiste Masson, Charlotte Floderer, Cyril Favard, Karen Perronet, Nathalie Westbrook, Christian L. Vestergaard, Delphine Muriaux, Alexander S. Serov

Publikováno v: Scientific Reports
Scientific Reports, 2020, 10 (1), pp.3783. ⟨10.1038/s41598-020-60220-1⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.3783. ⟨10.1038/s41598-020-60220-1⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

We devise a method to detect and estimate forces in a heterogeneous environment based on experimentally recorded stochastic trajectories. In particular, we focus on systems modeled by the heterogeneous overdamped Langevin equation. Here, the observed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a4d94587e3d65421b4b64cd37c8a39
https://hal-pasteur.archives-ouvertes.fr/pasteur-02865729/file/Robust_inference.pdf